- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effect of Chungsimyeonjaeum on myocardiac cell injury in mouse myoblast C2C12 cells
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.3, pp.25-36
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(2006). Effect of Chungsimyeonjaeum on myocardiac cell injury in mouse myoblast C2C12 cells. Journal of Korean Medicine, 27(3), 25-36.
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Abstract
Determination and differentiation of cells in the skeletal muscle lineage is positively regulated by cell-cell contact. Differentiation proteins proposed to mediate this effect include both classical MyoD and MEF members; potential interactions between the promyogenic activities of these classes of protein, however, are unknown. We show here that MyoD and MEF, two promyogenic family members that determine to each other in a cis fashion, form ineraction with MyoD and MEF. These proteins contain myosin heavy chain and are enriched at sites of cell-cell contact between myoblasts. Therefore, in differentiation of MyoD MEF from Chungsimyeonjaeum interact dependently, suggesting that the interactions occur in a cis fashion; consistent with this conclusion, MyoD-mediated differentiation is required for myoblast to occur by Chungsimyeonjaeum. Inhibition in myoblasts of a MyoD by Staurosporine in its ability to associate with MEF interferes with differentiation as assessed by morphological and transcription level, suggesting that this interaction is functionally important in myogenesis. Also, some of the differentiation-mediated proteins that are required for myogenesis seem to be based on interdependent activities of promyogenic classical smad-subfamilly.
- keywords
- MyoD, MEF, Chungsimyeonjaeum
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