- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Immunological Study of the Gami-sopunghwalhyeol tang(Ji？w？i-sh？f？nghu？xu？-tang: GSHT) on Rheumatoid Arthritis in Human Fibroblast-like Synoviocytes
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.3, pp.87-105
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(2006). Immunological Study of the Gami-sopunghwalhyeol tang(Ji？w？i-sh？f？nghu？xu？-tang: GSHT) on Rheumatoid Arthritis in Human Fibroblast-like Synoviocytes. Journal of Korean Medicine, 27(3), 87-105.
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Abstract
Objectives : This study was carried out to know the immunity responses of the Gami-sopunghwalhyeol-tang(Jiāwèi-shūfēnghuóxuè-tang)(hereinafter referred to GSHT) to the human fibroblast-like synoviocytes(hFLSs) isolated from patients with rheumatoid arthritis. Methods : For this purpose, experiments were performed to measure the cytotoxity against hFCs and the production of pro-inflammatory cytokines in hFLSs and the production of NO, ROS. Results : 1. The gene expression of TNF-α, IL-6, IL-8 in hFLSs were effectively reduced at 100 ㎍/㎖, whereas IL-1β was effectively reduced at 100, 10 ㎍/㎖ of GSHT. 2. The gene expression of ICAM-1, MMP-3 in hFLSs was effectively inhibited at 100, 10 ㎍/㎖ of GSHT, whereas TIMP-1 was effectively increased at 100, 10 ㎍/㎖ of GSHT. 3. The gene expression of NOS-Ⅱ in hFLSs was effectively inhibited at 100 ㎍/㎖ of GSHT. 4. The production of NO, ROS in hFLSs was inhibited at 100, 10 ㎍/㎖ of GSHT. 5. The proliferation of hFLSs was significantly inhibited at 100 ㎍/㎖ of GSHT. Conclusions : Comparison of the results for this study showed that Gami-sopunghwalhyeol-tang(Jāwèi-shūfēnghuóxuè-tang: GSHT) had immunomodulatory effects of suppressing or enhancing.
- keywords
- Gami-sopunghwalhyeol-tang(Jiāwèi-shūfēnghuóxuè-tang), Rheumatoid Arthritis, Immunomodulatory
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