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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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황약자가 갑상선기능항진 유발 백서에 미치는 영향

The Effects of Dioscorea bulbifera L. on the Hyperthyroidism of Rats

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.3, pp.178-186
남형신 (대전대학교 한의과대학)
조충식 (대전대학교 한의과대학)
김철중 (대전대학교 한의과대학)
남형신, 조충식, & 김철중. (2006). 황약자가 갑상선기능항진 유발 백서에 미치는 영향. 대한한의학회지, 27(3), 178-186.
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Abstract

Objective : The aim was to study experimentally the effects of Dioscorea bulbifera L. on the Hyperthyroidism of Rats induced by Sodium levothyroxine. Methods : Spargue-Dawley rats were separated into four groups. Except normal group, the other three groups were treated with sodium levothyroxine 160㎍/㎏/days for 5 days by oral administration. Among the three groups, two except one(as control) were treated Dioscorea bulbifera L. extract 0.75g/㎏/days(sample A), 1.5g/㎏/days(sample B) for 3 days separately. T3-uptake, T3, T4, TSH, total cholesterol, Glucose, ALP, AST, ALT, Free fatty acid, β-lipoprotein, change in the Serum of rats were measured after medication of solid extract of Dioscorea bulbifera L. Results : As a result of this study, T4 concentration and T3-uptake level were decreased in sample A and B compared to controls. T3 concentration was decreased but not statistically meaningful. Considering lipid metabolism, only free fatty acid level was significantly reduced and Glucose level was also significantly decreased in sample B. Serum AST, ALT and ALP levels were slightly elevated but there was no meaning statistically, which doesn't mean Dioscorea bulbifera L. has liver toxicity because the quantity of the extract maybe couldn't reached the minimal dose causing liver toxicity according to an article, in which minimal lethal dose of Dioscorea bulbifera L. was 60g. Body weight was significantly increased in comparison to controls. Conclusion : These results suggest that Dioscorea bulbifera L. lowers excess of thyroid hormone and increased metabolism, resulting in improvement of hyperthyroid state.

keywords
Hyperthyroidism, Dioscorea bulbifera L., Sodium levothyroxine.


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