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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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蔘芪地黃湯이 Streptozotocin에 의한 흰쥐의 糖尿病性 腎症에 미치는 영향

Beneficial Effect of Samgijiwhang-Tang on Diabetic Nephropathy Rats

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.3, pp.76-86
김상대 (동신대학교 한의과대학)
김용성 (동신대학교 한의과대학)
김상대, & 김용성. (2006). 蔘芪地黃湯이 Streptozotocin에 의한 흰쥐의 糖尿病性 腎症에 미치는 영향. 대한한의학회지, 27(3), 76-86.
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Abstract

Objectives : The present study was carried out to investigate the preventive effect of Samgijiwhang-Tang(SJT) on streptozotocin(STZ)-induced diabetic nephropathy. Methods : SJT was given to rats with oral administration. The experimental animals were divided into normal group of rats, control group of STZ-induced diabetic rats, and sample group with SJT administration. Rehmanniae Radix Preparat is combined in the original prescription of SJT, but in this experiment, Rehmanniae Radix was combined instead of Rehmanniae Radix Preparat to compare the effect of anti diabetic nephropathy. Experimental diabetic nephropathy was induced by the injection of STZ(60㎎/㎏) to the rat via the peritoneum. The effect of SJT on STZ-induced diabetic nephropathy was observed by measuring the serum level of creatinine and BUN. Urine secretion of albumin for 24 hours and urine level of glucose measures too. Anti-oxidative stress of SJT administration in living body was estimated by measuring lipid peroxide and GSH content in cortex of kidneys. Result : STZ induced increase of serum creatinine, urine glucose and renal cortical lipid peroxidation were lowered by Rehmanniae Radix Preparat combined SJT administration. Conclusion : The SJT treatment showed protective effect on rat diabetic nephropathy model, and action mechanism of the effect was thought to be concerned with anti-oxidative stress.

keywords
Samgijihwang-Tang(SJT), Diabetes, Diabetic nephropathy


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