ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
사전등록 바로가기
 

논문 상세

Home > 논문 상세
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

이전

다음

28권 3호
Share

Ob/ob mouse에서 五精丸이 혈당, 고지혈증, Polyol Pathway 및 항산화작용에 미치는 영향

Effects of Ojung-hwan on Blood Glucose, Hyperlipidemia, Polyol Pathway and Antioxidative Mechanism in Ob/ob Mouse

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.3, pp.57-69
공태현 (동국대학교 한의과대학 내과학교실)
정지천 (동국대학교 한의과대학 내과학교실)
공태현, & 정지천. (2007). Ob/ob mouse에서 五精丸이 혈당, 고지혈증, Polyol Pathway 및 항산화작용에 미치는 영향. 대한한의학회지, 28(3), 57-69.
  • 다운로드 수
  • 조회수

Abstract

Objectives : Diabetes is a disease in which the body does not produce or properly use insulin. Etiological studies of diabetes and its complications have shown that oxidative stress might play a major role. Therefore, many methods have been tried to regulate free oxygen radicals for treating diabetes and its complications. Ojung-hwan, composed of five crude herbs, has been considered effective for treating symptoms of aging. In male ob/ob mouse of severe obesity, hyperinsulinemia and hyperlipidemia, which are features of NIDDM, the hyperglycemic activities and mechanisms of Ojung-hwan were examined. Methods : Mice were grouped and treated for 5 weeks as follows. Both the lean (C57/BL6J black mice) and diabetic (ob/ob mice) control groups received standard chow. The experimental groups were fed a diet of chow supplemented with 30 and 90 mg Ojung-hwan per 1 kg of body weight for 14 days. The effects of Ojung-hwan extract on the ob/ob mice were observed by measuring the serum levels of glucose, insulin, lipid components, and the kidney levels of superoxide anion radical ( O2 -), MDA+HAE, GSH/GSSG ratio, and also the enzyme activities involved in polyol pathway. Results : Ojung-hwan lowered the levels of serum glucose and insulin in a dose-dependent manner. Total cholesterol, triglyceride and free fatty acid levels decreased, while the HDL-cholesterol level increased, in Ojung-hwan treated groups. Renal aldose reductase and sorbitol dehydrogenase activities increased in the ob/ob mice, whereas they were inhibited in the Ojung-hwan treated groups. Ojung-hwan inhibited the generation of O2 - in the kidney. Finally, MDA+HAE levels increased and GSH/GSSG ratio decreased in the ob/ob mice, whereas they improved in the Ojung-hwan treated groups. Conclusions : Ojung-hwan showed antidiabetic and antihyperlipidemic activities by regulating theactivities of polyol pathway enzymes, scavenging reactive oxygen species and reducing the MDA+HAE levels in the ob/ob mice.

keywords
Ojung-hwan (wujing-wan), ob/ob mouse, antidiabetic activities, hyperlipidemia, polyol pathway, oxidative stress, Ojung-hwan (wujing-wan), ob/ob mouse, antidiabetic activities, hyperlipidemia, polyol pathway, oxidative stress


참고문헌

1

(1985;34) The molecular mechanism of insulin action,

2

(1999) 임상내분비학, 서울:고려의학

3

(1997) Pathogenesis of type 2 diabetes. Metabolic and molecular implications for identifying diabetes genes,

4

(1995) Pathophysiology of insulin resistance in human disease,

5

(1987) The potential role of oxidative stress in diabetes and its complications Novel implication for theory and therapy in diabetic complications,

6

(1991) Role of oxidative stress in development of complications in diabetes,

7

(1991) Aminoguanidine treatment inhibit the development of experimental diabetic retinopathy,

8

(1991;7) Glucose-induced metabolic imbalance in the pathogenesis of diabetic vascular disease,

9

(1994;94) The linked roles of nitric oxide aldose reductase and Na-K-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat,

10

(1998) 消渴의 傳變證과 당뇨병의 만성합병증에 대한 비교 고찰,

11

(2002) ob/ob mice에서 순기산의 항당뇨 활성 및 기전 연구,

12

(2003) 竹瀝과 누에가루 배합약물이 db/db mouse의 혈당 강하에 미치는 영향,

13

(2004) 珍糖元의 고혈당 조절 작용 및 기전에 관한 연구,

14

(2006) 고혈당 흰쥐에서 蠐螬의 혈당 조절과 항산화작용에 관한 연구,

15

(2002) 中老年保健養生方, 北京:學苑出版社

16

(1966;13) Colorimetric glucose oxidase method for blood glucose,

17

(1977;23) Use of an enzymatic method for cholesterol designed for continuous flow instrumention,

18

(1968;22) A colorimetric method for estimation serum triglyceride,

19

(1995) Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA,

20

(1983;134) Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein fluorescent assay,

21

(1991;11) Chemistry and Biochemistry of 4-Hydroxynonenal,

22

(1967;104) A spectrophotometric method for the direct determination of cystein in the presense of other naturally occuring amino acid,

23

(1951;193) Protein measurement with folin phenol reagent,

24

(1998) Non-insulin dependent diabetes mellitus. A genetically programmed failure of the β cell to compensate for insulin resistance,

25

(1985;110-37) Animal models of diabetes mellitus,

26

(1992;8) Animal models of non-insulin-dependent diabetes,

27

(1989;9) Increased plasma levels of glutathione and malondialdehyde after avute ethanol ingestion in humans,

  • 다운로드 수
  • 조회수
  • 0KCI 피인용수
  • 0WOS 피인용수

권호 내 다른 논문

추천 논문

상단으로 이동

권호 목록

소개

규정 및 지침

게시판

대한한의학회지

  학술지 홈페이지 이용 환경은   크롬 브라우저 사용을 권장합니다.

대한한의학회지

논문 투고 OA 정책