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- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Effects of Hirudo on Streptozotocin-induced Diabetic Nephropathic Rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.4, pp.133-145
&
(2008). The Effects of Hirudo on Streptozotocin-induced Diabetic Nephropathic Rats. Journal of Korean Medicine, 29(4), 133-145.
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Abstract
Objectives: The aim of present study was to investigate recovery effects of Hirudo, which has been used clinically in diabetes therapy. Methods: We established three groups: normal, control, Hirudo, and assigned 6 rats to each group. The normal group was not treated by any process and fed by normal saline. The control & Hirudo groups were administered streptozotocin (STZ) to induce diabetes. Hirudo extract was orally administered to the Hirudo group for 10 days. After 8 weeks, the rats were sacrificed and their body weight, 24hrs urinary protein excretion, glucose, albumin, BUN, creatinine, total-cholesterol, LDL-cholesterol, triglyceride in blood, and level of glycation end-product (AGE) and transforming growth factor (TGF-β1) in serum were measured. Morphological profiles and morphometric studies of the kidney cortex, renal transforming growth factor (TGF-β1) expression, and renal receptor for advanced glycation end-products (RAGE) expression were studied. Results: The following results were obtained. The protein amount in urine per 24hrs of the Hirudo-treated group as compared to the control group was significantly reduced. The BUN and creatinine level in serum of the Hirudo-treated group as compared to the control group was significantly inhibited. The construction change in kidney of the Hirudo-treated group as compared to the control group was significantly inhibited. The factor of the Hirudo-treated group as compared to the control group was significantly inhibited, which induced the construction change in kidney. Conclusions: The above results suggest that Hirudo partially improved the function of the kidney.
- keywords
- Hirudo, streptozotocin, diabetic nephropathy
Reference
1
1. Isselbacher, K.J., Braunwald, E., Wilson, J.D., Martin, J.B., FAuci, A.S., & Kasper, D.L. HARRION’S Principles of Internal Medicine. 서울:MIP. 2003,2188-91.
2
2. 대한내분비학회. 내분비학. 서울:고려의학. 1999: 1006, 1127-33.
3
3. 대한신장학회. 임상 신장학. 서울:광문출판사. 2001:321-38.
4
4. 강석봉. 소갈의 전변증과 당뇨병의 만성합병증에 대한 비교 고찰. 대한한의학회지. 1998; 19 (2):137-51.
5
5. 두호경, 안세영, 안영민. 당뇨병의 만성합병증에 대한 한의학적 고찰. 경희의학. 1998;14(3․4): 245-56.
6
6. 陳貴廷, 楊思澍. 實用中西醫結合 診斷治療學. 北京:中國醫藥科技出版社. 1991:527-30.
7
7. 김성아, 강윤호. 당뇨병성 신증의 한의학적 접근 및 치료에 대한 연구. 대한한의정보학회지. 2005; 11(2):1-13.
8
8. 김창민, 신민교, 이경순, 안덕균. 국역중약대사전. 서울:정담. 2004:2566.
9
9. 武繼彪, 劉紅兵, 呂文海. 3種 水蛭 制品 調脂作用比較, 中國中藥雜誌. 1994;34(3):343-5.
10
10. 홍석, 변일. 水蛭에 대한 文獻的 考察. 혜화의학. 1993;1(2):55-66.
11
11. 한동하, 정희재, 정승기, 이형구. 水蛭의 임상적 활용에 대한 문헌적 고찰. 대한한의학학회지. 2002 ;23(2):151-63.
12
12. 박창국. 熊膽 및 水蛭이 瘀血病態模型에 미치는 影響. 동서의학. 1994;16(2):5-42.
13
13. 안규석. 蚯蚓, 水蛭, 蠐螬 및 蜈蚣이 血栓症에 미치는 影響. 대한한의학회지. 1990;11(2):92-101.
14
14. 이주용, 김은경, 오현아, 이현삼, 손영주, 정혁상, 김윤범, 박성규, 손낙원. 水蛭이 비만세포의 알러지 염증 반응에 미치는 영향. 대한한의학회지. 2008;29(2):81-95.
15
15. Shi, S-R., Key, M.E., & Kara, K.L. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunoh- istochemical staining based on microwave oven heating of tissue sections. J. Histochem. Cytoc- hem. 1991;39(6):742-8.
16
16. Hsu, S.M., Raine, L., & Fanger, H. The use of avidin-biotin-peroxidase complex (ABC) in imm- unoperoxidase techniques. A comparison between ABC and unlabeled antibody PAP procedures. J Histochem Cytochem. 1981;29(4):577-80.
17
17. 이현숙, 이종록, 최광성, 신정현, 최혜영. 나 병변 조직에서 Smad 2와3의 발현. 대한피부과학회지. 2006;44(3):304-308
18
18. 이태희. 임상당뇨병학. 서울:고려의학. 1999:113.
19
19. 대한당뇨병학회. 당뇨병학. 서울:고려의학. 1998: 471-5.
20
20. Futoshi Shintani. Steps to Internal medicine. 서울:정담. 2002:155-6, 167-76.
21
21. 서울대학교병원 신장내과. 임상신장학 입문. 서울:신흥메드싸이언스. 2002:218-22.
22
22. 張仲景. 完譯金匱要略. 서울:서원당. 1986:57, 384-5.
23
23. 王燾. 外臺秘要. 서울:성보사. 1975:294.
24
24. 趙佶. 聖濟總.. 北京:人民衛生出版社. 1992:1064, 1078.
25
25. 朱櫹. 鈂定四庫全書(普濟方). 서울:대성문화사. 1995:502.
26
26. 陳以平. 腎病的辨證與辨病治療. 北京: 民衛生出版社. 2003:152.
27
27. 강계원. 잊혀져 가는 생물-거머리. 서울:도서출판아카데미. 1995:19, 41, 89.(727)
28
28. 著者未詳. 神農本草經. 太原:山西科學技術出版社. 199:118.
29
29. 許浚. 東醫寶鑑. 서울:남산당. 1994:708.
30
30. 黃宮綉. 本草求眞. 서울:의성당. 1993:234.
31
31. 李時珍. 本草綱目. 북경:人民衛生出版社. 1982: 2285-8.
32
32. 장개빈. 경악전서. 서울:도서출판 한미의학. 2006: 2542.
33
33. 全國韓醫科大學 本草學敎室 共編著. 本草學. 서울:永林社. 1992:.431.
34
34. 董昆山. 現代臨床中藥學. 北京:中國中醫藥出版社. 1998:522-4.
35
35. 齊智勇. 專題筆談. 中醫雜誌. 1993;34(4):197-9.
36
36. 김용성, 김철중, 성현제. 인삼백호탕이 Alloxan으로 유도된 mouse의 당뇨병성 신증에 미치는 영향. 한국한의학연구원논문집. 2000;5(1):17-25.
37
37. 나건호, 조명래, 조수인. 糖尿1號方의 藥鍼 및 口腔投與가 Streptozotocin으로 유발된 흰쥐의 糖尿病性 腎症에 미치는 영향. 대한침구학회지. 2005;22(5):1-10.
38
38. 서수환, 김용성. 六味地黃湯이 Alloxan으로 誘發된 mouse의 糖尿病性 腎症에 미치는 影響. 대한한방내과학회지. 2005;26(4):741-52.
39
39. 조현주, 김용성. 蔘芪地黃湯加丹蔘, 大黃, 紅花가 Streptozotocin으로 유발된 생쥐의 糖尿病性 腎症에 미치는 영향. 대한한방내과학회지. 2005;26 (4);767-75.
40
40. 양용준, 김연섭. 석산이 Streptozotocin으로 유발된 당뇨에 대한 면역조직화학적 연구. 대한본초학회지. 2004;19(1):111-9.
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