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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Overview for Immune-related Efficacies and their Mechanisms of Ginseng

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.5, pp.118-125


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Abstract

Objective:Ginseng is one of the most popular Oriental medicinal plants considered as a tonic worldwide. This study aimed to produce comprehensive understanding for immune-related pharmaceutical activities of Ginseng. Methods: We surveyed all literatures, 168 of immunity-focused papers with Ginseng in Pub-med, and analyzed pharmaceutical characters according to immune elements and Ginsengʼ components. Results:The main functions of Ginseng have been associated with modulation of immunity. Whole body of Ginseng or its ingredients differently show the effects on both cellular and humoral elements of immune system. Ginseng enhances the activities of T and B lymphocytes, NK cells, macrophages and dendritic cells whileas suppresses mast cell-associated allergy and release of histamine. Conclusion:These results will provide Korean doctors or scientists an immune-related overview of Ginseng, and help them in clinical applications and developments of Korean Ginseng as a global competitive drug in world market.

keywords
Ginseng, Immunity, Oriental Medicine


Reference

1

1. Chong SKF, Oberholzer VG. Ginseng is there a use in clinical medicine? Postgrad Med J. 1988; 64:841-6.

2

2. Park HJ, Son CG. Systematic Analysis of Ginseng- focused Research Worldwide. J Korean Oriental Med. 2008;29:60-6.

3

3. Zeng XL, Tu ZG. Induction of differentiation by ginsenoside Rh2 in hepatocarcinoma cell SMMC- 7721 Ai Zheng. 2004;23:879-84.

4

4. Cui Y, Shu XO, Gao YT, Cai H, Tao MH, Zheng W. Association of ginseng use with survival and quality of life among breast cancer patients. Am J Epidemiol. 2006;163:645-53.

5

5. Schliebs R, Liebmann A, Bhattacharya SK, Kumar A, Ghosal S, Bigl V. Systemic administration of defined extracts from Withania somnifera (Indian Ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and GABAergic markers in rat brain. Neurochem Int. 1997;30:181-90.

6

6. LinksJi YC, Kim YB, Park SW, Hwang SN, Min BK, Hong HJ, Kwon JT, Suk JS. Neuroprotective effect of ginseng total saponins in experimental traumatic brain injury. J Korean Med Sci. 2005; 20:291-6.

7

7. Zhang YG, Liu TP. Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats. Zhongguo Yao Li Xue Bao. 1996;17: 44-8.

8

8. Martinez-Mir I, Rubio E, Morales-Olivas FJ, Palop-Larrea V. Transient ischemic attack secondary to hypertensive crisis related to Panax ginseng. Ann Pharmacother. 2004;38:1970.

9

9. Huong NT, Matsumoto K, Watanabe H. The antistress effect of majonoside-R2, a major saponin component of Vietnamese ginseng: neuronal mechanisms of action. Methods Find Exp Clin Pharmacol. 1998;20:65-76.

10

10. Huong NT, Murakami Y, Tohda M, Watanabe H, Matsumoto K. Social isolation stress-induced oxidative damage in mouse brain and its modulation by majonoside-R2, a Vietnamese ginseng saponin. Biol Pharm Bull. 2005;28:1389-93. (922)

11

11. Block KI, Mead MN. Immune system effects of echinacea, ginseng, and astragalus: a review. Integr Cancer Ther. 2003;2:247-67.

12

12. Park EK, Shin YW, Lee HU, Kim SS, Lee YC, Lee BY, Kim DH. Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide. Biol Pharm Bull. 2005;28:652-6.

13

13. Radad K, Gille G, Liu L, Rausch WD. Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci. 2006;100: 175-86.

14

14. Kiefer D, Pantuso T. Panax ginseng. Am Fam Physician. 2003;68:1539-42.

15

15. Larsen MW, Moser C, Høiby N, Song Z, Kharazmi A. Ginseng modulates the immune response by induction of interleukin-12 production. APMIS. 2004;112(6):369-73.

16

16. Liou CJ, Huang WC, Tseng J. Short-term oral administration of ginseng extract induces type-1 cytokine production. Immunopharmacol Immunotoxicol. 2006;28(2):227-40.

17

17. Liou CJ, Li ML, Tseng J. Intraperitoneal injection of ginseng extract enhances both immunoglobulin and cytokine production in mice. Am J Chin Med. 2004;32(1):75-88.

18

18. Pannacci M, Lucini V, Colleoni F, Martucci C, Grosso S, Sacerdote P, Scaglione F. Panax ginseng C.A. Mayer G115 modulates pro-inflammatory cytokine production in mice throughout the increase of macrophage toll-like receptor 4 expression during physical stress. Brain Behav Immun. 2006;20(6):546-51.

19

19. Cho KM, Hong SY, Lee SM, Kim YH, Kahng GG, Lim YP, Kim H, Yun HD. Endophytic bacterial communities in ginseng and their antifungal activity against pathogens. Microb Ecol. 2007;54(2):341-51.

20

20. Raman P, Dewitt DL, Nair MG Lipid peroxidation and cyclooxygenase enzyme inhibitory activities of acidic aqueous extracts of some dietary supplements. Phytother Res. 2008;22(2): 204-12.

21

21. Seo JY, Lee JH, Kim NW, Her E, Chang SH, Ko NY, Yoo YH, Kim JW, Seo DW, Han JW, Kim YM, Choi WS. Effect of a fermented ginseng extract, BST204, on the expression of cyclooxygenase-2 in murine macrophages. Int Immunopharmacol. 2005;5(5):929-36.

22

22. Assinewe VA, Amason JT, Aubry A, Mullin J, Lemaire I. Extractable polysaccharides of Panax quinquefolius L. (North American ginseng) root stimulate TNF-alpha production by alveolar macrophages. Phytomedicine. 2002;9(5):398-404.

23

23. Kim JY, Lee HJ, Kim JS, Ryu JH. Induction of nitric oxide synthase by saponins of heat-processed ginseng. Biosci Biotechnol Biochem. 2005; 69(5):891-5.

24

24. Kang KA, Kang JH, Yang MP. Ginseng total saponin enhances the phagocytic capacity of canine peripheral blood phagocytes in vitro. Am J Chin Med. 2008;36(2):329-41.

25

25. Chen D, Wang SL, Wang YP. Experimental study on expression of GM-CSF from human endothelial cells and monocytes induced by total saponins of panax ginseng. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003;23(11):845-7.

26

26. Lee SH, Seo GS, Ko G, Kim JB, Sohn DH. Anti-inflammatory activity of 20(S)-protopanaxadiol: enhanced heme oxygenase 1 expression in RAW 264.7 cells.Planta Med. 2005;71(12): 1167-70.

27

27. Luo YM, Cheng XJ, Yuan WX. Effects of ginseng root saponins and ginsenoside Rb1 on immunity in cold water swim stress mice and rats. Zhongguo Yao Li Xue Bao. 1993 Sep; 14(5):401-4.

28

28. Cho JY, Kim AR, Yoo ES, Baik KU, Park MH. Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation. Planta Med. 2002;68(6):497-500.

29

29. Rivera E, Ekholm Pettersson F, Inganas M, Paulie S, Gronvik KO. The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response. Vaccine. 2005;23(46-47):5411-9.

30

30. Kimura Y, Sumiyoshi M, Kawahira K, Sakanaka M. Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice. Br J Pharmacol. 2006;148(6):860-70.

31

31. Niu YP, Jin JM, Gao RL, Xie GL, Chen XH. Effects of Ginsenosides Rg1 and Rb1 on Proliferation of Human Marrow Granulocyte-Macrophage Progenitor Cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2001;9(2):178-80.

32

32. Ro JY, Ahn YS, Kim KH. Inhibitory effect of ginsenoside on the mediator release in the guinea pig lung mast cells activated by specific antigenantibody reactions. Int J Immunopharmacol. 1998; 20(11):625-41.

33

33. Cho JY, Yoo ES, Baik KU, Park MH, Han BH. In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNFalpha antagonists. Planta Med. 2001;67(3):213-8.

34

34. Jeong HG, Pokharel YR, Han EH, Kang KW Induction of cyclooxygenase-2 by ginsenoside Rd via activation of CCAAT-enhancer binding proteins and cyclic AMP response binding protein. Biochem Biophys Res Commun. 2007;359(1): 51-6.

35

35. Liu M, Zhang JT. Immunoregulatory effects of ginsenoside Rg1 in aged rats. Yao Xue Xue Bao. 1995;30(11):818-23.

36

36. Lee EJ, Ko E, Lee J, Rho S, Ko S, Shin MK, Min BI, Hong MC, Kim SY, Bae H. Ginsenoside Rg1 enhances CD4(+) T-cell activities and modulates Th1/Th2 differentiation. Int Immunopharmacol. 2004;4(2):235-44.

37

37. Fan ZH, Isobe K, Kiuchi K, Nakashima I Enhancement of nitric oxide production from activated macrophages by a purified form of ginsenoside (Rg1). Am J Chin Med. 1995;23(3-4):279-87.

38

38. Wu CF, Bi XL, Yang JY, Zhan JY, Dong YX, Wang JH, Wang JM, Zhang R, Li X. Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia. Int Immunopharmacol. 2007;7(3):313-20.

39

39. Yu JL, Dou DQ, Chen XH, Yang HZ, Guo N, Cheng GF. Protopanaxatriol-type ginsenosides differentially modulate type 1 and type 2 cytokines production from murine splenocytes. Planta Med. 2005;71(3):202-7.

40

40. Yu JL, Dou DQ, Chen XH, Yang HZ, Guo N, Cheng GF. Immunoenhancing activity of protopanaxatriol- type ginsenoside-F3 in murine spleen cells. Acta Pharmacol Sin. 2004;25(12):1671-6.

41

41. Min JK, Kim JH, Cho YL, Maeng YS, Lee SJ, Pyun BJ, Kim YM, Park JH, Kwon YG. 20(S)- Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway. Biochem Biophys Res Commun. 2006;349(3):987-94.

42

42. Surh YJ, Lee JY, Choi KJ, Ko SR. Effects of selected ginsenosides on phorbol ester-induced expression of cyclooxygenase-2 and activation of NF-kappaB and ERK1/2 in mouse skin. Ann N Y Acad Sci. 2002;973:396-401.

43

43. Park YC, Lee CH, Kang HS, Kim KW, Chung HT, Kim HD. Ginsenoside-Rh1 and Rh2 inhibit the induction of nitric oxide synthesis in murine peritoneal macrophages. Biochem Mol Biol Int. 1996;40(4):751-7.

44

44. Park EK, Choo MK, Kim EJ, Han MJ, Kim DH. Antiallergic activity of ginsenoside Rh2. Biol Pharm Bull. 2003;26(11):1581-4.

45

45. Bae EA, Han MJ, Shin YW, Kim DH. Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. Biol Pharm Bull. 2006;29(9):1862-7.

46

46. Takei M, Tachikawa E, Hasegawa H, Lee JJ. Dendritic cells maturation promoted by M1 and M4, end products of steroidal ginseng saponins metabolized in digestive tracts, drive a potent Th1 polarization. Biochem Pharmacol. 2004;68 (3):441-52.

47

47. Yu JL, Dou DQ, Chen XH, Yang HZ, Hu XY, Cheng GF. Ginsenoside-Ro enhances cell proliferation and modulates Th1/Th2 cytokines production in murine splenocytes. Yao Xue Xue Bao. 2005;40(4):332-6.

48

48. Ma L, Zhou ZL, Yang Q. Study on effect of polysaccharides of ginseng on peripheral blood mononuclear cell induced interleukin-2 production and activity of its receptors in vitro. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995;15(7):411-3.

49

49. Park KM, Kim YS, Jeong TC, Joe CO, Shin HJ, Lee YH, Nam KY, Park JD. Nitric oxide is involved in the immunomodulating activities of acidic polysaccharide from Panax ginseng. Planta Med. 2001;67(2):122-6.

50

50. Sonoda Y, Kasahara T, Mukaida N, Shimizu N, Tomoda M, Takeda T. Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng. Immunopharmacology. 1998;38(3):287-94.

51

51. Hasegawa H, Suzuki R, Nagaoka T, Tezuka Y, Kadota S, Saiki I. Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol. Biol Pharm Bull. 2002;25 (7):861-6.

52

52. Nakata H, Kikuchi Y, Tode T, Hirata J, Kita T, Ishii K, Kudoh K, Nagata I, Shinomiya N. Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells. Jpn J Cancer Res. 1998;89(7):733-40.

53

53. Akagawa G, Abe S, Tansho S, Uchida K, Yamaguchi H. Protection of C3H/HE J mice from development of Candida albicans infection by oral administration of Juzen-taiho-to and its component, Ginseng radix: possible roles of macrophages in the host defense mechanisms. Immunopharmacol Immunotoxicol. 1996;18(1):73-89.

54

54. Jeong HJ, Koo HN, Myung NI, Shin MK, Kim JW, Kim DK, Kim KS, Kim HM, Lee YM. Inhibitory effects of mast cell-mediated allergic reactions by cell cultured Siberian Ginseng. Immunopharmacol Immunotoxicol. 2001;23(1): 107-17.

55

55. Kim DS, Oh SR, Lee IS, Jung KY, Park JD, Kim SI, Lee HK. Anticomplementary activity of ginseng saponins and their degradation products. Phytochemistry. 1998;47(3):397-9.

56

56. Zhuravlev YN, Koren OG, Reunova GD, Muzarok TI, Gorpenchenko TY, Kats IL, Khrolenko YA. Panax ginseng natural populations: their past, current state and perspectives. Acta Pharmacol Sin. 2008;29(9):1127-36.

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