- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effect of Tongqiao-tang on OVA Induced Allergic Rhinitis Mouse Model
대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.5, pp.96-103
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
이규진,
남혜정,
&
김윤범.
(2008). . 대한한의학회지, 29(5), 96-103.
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Abstract
Objectives:Tongqiao-tang(TQT) has been commonly used for the treatment of common cold, rhinitis etc. Nowadays, TQT becomes one of the most frequently used medicines for allergic rhinitis, but the mechanism of TQT in vivo isn’t investigated yet. This study was performed to investigate the effect of TQT on OVA-induced allergic rhinitis mouse model by calculating serum cytokines and IgE. Methods:8 weeks aged male BALB/c mice were divided into three groups: the normal group, the control group and the medicated group (the TQT group). Each group was consisted of 15 mice. The TQT group was administered TQT extract orally one time a day (1g/kg) from the 1st day of experiment till the 26th day. The control group and the normal group were administered normal saline by the same method of the TQT group. To induce the allergic rhinitis in the control group and the TQT group, mice of each group were sensitized intraperitoneally with ovalbumin (OVA) solution at the 1st, the 7th and the 14th day. After then, intranasal sensitization was performed by dropping 0.1% OVA solution in nasal cavity at the 22th, the 24th and the 26th day . At the 27th day, the mice were killed and the changes of interferon-γ, interleukin-4, interleukin-5, total IgE and OVA-specific IgE were checked. Results:IFN-γ was increased 36% more in the TQT group than that in the control group. IL-4, IL-5, the total IgE and OVA-specific IgE were decreased in the TQT group as compared with the control group and these results were statistically significant. Conclusions:Considering the above experimental results, this study showed that TQT could reduce the allergic reaction in allergic rhinitis. Advanced studies are required to investigate the further mechanisms of TQT.
- keywords
- Tongqiao-tang, OVA-induced allergy model, cytokines, IgE
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