- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effect of Yukmijihwangtang on Learning and Memory Impairment in Transient Focal Cerebral Ischemia Rat Model
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2009, v.30 no.2, pp.1-16
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(2009). Effect of Yukmijihwangtang on Learning and Memory Impairment in Transient Focal Cerebral Ischemia Rat Model. Journal of Korean Medicine, 30(2), 1-16.
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Abstract
Objectives:This study investigated the effect of Yukmijihwangtang on cerebral ischemia-induced learning and memory impairment by middle cerebral artery (MCA) occlusion in rats. Methods:The ability of learning and memory of rats was measured using the eight-arm radial maze and the passive avoidance test, and profile of cholinergic neuron was assessed in the medial septum and hippocampus region by immuno-histochemistry. Results:1. No differences were found between groups in the number of correct choices in acquisition performance during the eight-arm radial maze task. 2. No differences were found between groups on day 1 in the error rate in acquisition performance, which is defined as the number of enters into the same arm more than once within five minutes. After 5 to 6 days of test, the number of errors was significantly reduced in the Yukmijihwangtang group (forebrain ischemia group with Yukmijihwangtang treatment), compared with the ischemia group. 3. The memory processes significantly improved in the Yukmijihwangtang group according to results of the passive avoidance test. 4. The appearance of AchE (acetylcholinesterase) in the CA1 region of hippocampus significantly decreased in the ischemia group, compared with the sham group (untreated group). The appearance of AchE in the same region significantly increased in the Yukmijihwangtang group, compared with the ischemia group. 5. The appearance of ChAT (choline acetyltransferase) in the CA1 region of the hippocampus and medial septum decreased in the ischemia group, compared with the sham group. The appearance of ChAT in the same region significantly increased in the Yukmijihwangtang group, compared with the ischemia group Conclusions:This study provides evidence that Yukmijihwangtang is effective for reviving the ability of learning and memory and damaged neurons in rats with experimental cerebral ischemia.
- keywords
- Yukmijihwangtang, focal cerebral ischemia, learning and memory impairment, eight-arm radial maze, passive avoidance test, hippocampus
Reference
1
1 Siesjo,B.K. Cerebral circulation and metabolism. J neurosurg. 1984;60:883-908.
2
2 Winn,R.H., Welsh,J.E., Rubio, R. and Berne. R.M. Changes in brain adenosine during bicucullinginduced seizures in rat. Effects hypoxia and altered systemic blood pressure. Circ Res. 1980; 47:568-77.
3
3 Zetterstorm, T., Vernet, L., Ungerstedt, U., Tossman, U.,Jonson, B. and Fredholm, B. Purine levels the intact rat brain. Studies with an implanted perfused hollow fibet. Neurosci lett. 1982;29: 111-5.
4
4 Petito,C. K., Feldmann, E., Pulsinelli, W.A. and Plum,F. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology. 1987;37:1281-6.
5
5 Lee YS, Yun BW, Roh JK. Neuroprotective Effects of Lamotrigine in Transient Global Ischemia. Journal of the Korean Neurological Association. 1998;16(2):113-8.
6
6 Waytt,J.S., Edward, A.D., Azzopardi, D. and Reynolds, E. Magnetic resonance and near infrared spectroscopy for investigation of perinatal hypoxicinchemic brain injury. Arch Dis child. 1989;64: 953-63.
7
7 王永. 黃帝內經靈樞. 臺北. 대만중화서국. 1982:145
8
8 王水. 黃帝內經素問. 臺北 : 대만중화서국. 1982:23,122.
9
9 張仲景. 金匿野各. 北京:人民衛生出版士. 1989:166.
10
10 錢乙. 小見轎登直訣. 北京:人民衛生出版社. 1989:22.
11
11 Lee WS, Park SD. A Literatural Study on the YukMiGiHwangTang. The Journal of Dong Guk Oriental Medicine. 1996;5(1):164.
12
12 Choi BE, Bae HS, Shin MK, Hong MC. Effect on Gene Expression Profile of Rat Hippocampus Caused by Administration of Memory Enhancing Herbal Extract. Korean Journal of Oriental Physiology and Pathology. 2002;16(5):1025-34.
13
13 Koo JS, Kim JH. An exprimental Study of the Effects of Yukmijiwhangtanggamibang on Growth, Learning and Memory of Rats. The Journal of Korean Oriental Pediatrics. 2005;19(1):67-82.
14
14 Park EH, Chung MS, Park CB, Chi SE, Lee YH, Bae HS, Shin MK, Kim HT, Hong MC. Clinical Study for YMG-1,2's Effects on Learning and Memory Abilities. Korean Journal of Oriental Physiology and Pathology. 2002;16(5):976-988.
15
15 Lee JH. Experimental Study on Correlation of memory and Function of Kidneys. The Journal of Oriental Medical Physiology. 1991;6(1):59-76.
16
16 Jeong HW, Back YC, Kim JS. Experimental Effects of Yukmijihwangtanggamipang on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats. The Academic Society of Oriental Medical Physiology. 2000;14(2):245-55.
17
17 Kim JH, Kim YS, Seol IC, Kim DH. Study on the Effect of Gamiyukmijihwang-tang on the Brain damage. The Academic Society of Oriental Medical Physiology. 2003;17(2):467-75.
18
18 홍 경. 六昧地黃丸, 骨氣丸要八咪地黃元이 血壓 과 局所腦血流量에 미치는 影響. 東新大學校大學院(碩士). 1999.
19
19 Zea L,Weinstein P, Carlson S, Summins. Reversible middle cerebral artery occlusion without craniectomy in rats. Storke. 1989;20:84-91.
20
20 Strujkstra AM, Bolhuis JJ. Memory persistence of rats in a radial maze vaties with training procedure. Behavioral and Neural Biology. 1987;47: 158-66.
21
21 현정환. 아동발달의 이해. 서울:창지사. 2005:28
22
22 金正鎮. 生理學. 서울:高文社. 1986:217,226-32.
23
23 아담스 신경과학편찬위원회 역. 아담스 신경과학. 서울: 정담. 1998:720-2.
24
24 Kirino, T. Delayedneuronal death in the gerbil hippocampus following ischemia. Brain Res. 1982;239:57-69.
25
25 Bonnekoh,P., Barbier,A., Oschlies,U. and Hossmann, K. A. Selective vulnerability in the gerbil hippocampus: orphological change after 5-min ischemia and long survival times. Acta Neurophthol. 1990; 80:18-25.
26
26 Kim SH, Kim HT. Functional Neuroanatomy of Learning and Memory. The Korean Journal of Psychopathology. 1999;8(1):22-34.
27
27 장동환 외 2인. 심리학 입문. 서울:박영사. 1991: 214.267.272.313.
28
28 Park NJ. The Neuromolecular Approach to Memory. Wonkwang Psychiatry. 1991;7(2):7-8.
29
29 민성길. 增補 最新精神醫學. 서울: 一朝閣 . 1991:29-30,101-2.
30
30 이정균. 改訂版 精神醫學. 서울:一朝閣 .1992:208-9,421-2.
31
31 McEwen BS. Stress and the aging hippocampus. Front Neuroendocrinol. 1999:20:49-70.
32
32 Nestler EJ, MaMahon A, Sabban EL, Tallman JF, Duman RS. Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus. USA:Proc Natl Acad Sci. 1990;87:7522-6.
33
33 Gray JA, McNaughton N. Comprasion between the behavioral effects of septal and hippocampal lession.: A review. Neuroscience and biobehavioral Reviews. 1982;7:119-88.
34
34 Johnston M, Mckinney M, Coyle J. Evidence for a cholinergic projection to neocortex form neurons in basal forebrain. Proceedings of the National Academy of Science. 1979;76:5392-6.
35
35 Lippa A.S.,Pelham R.W.,Beer B., Crichett D.J., Dean R.J., Bartus R.T. Brain cholinergic dysfunction and memory in aged rats. Neurobiol. Aging.I. 1965:13-19.
36
36 Mckinney M., Coyle J.T., Hedreen J.C. Topographic analysis of the innervation of the rat neocortex and hippocampus by basal forebrain cholinergic system. J. Comp. Neutrol. 1983;217:103-21.
37
37 Jack R. Cooper, Floyd E. Bloom and Robert H. Roth. The biochemical basis of neuropharmacology. 7th ed. Oxford University Press. 1996:194-222.
38
38 趙鴻斌, 王雨亭. 心腦血管病中醫證治學. 北京:學術古刊卅版社. 1990:44-6.
39
39 김기석. 뇌. 서울:성원사. 1989:49-50.
40
40 孫思道. 俯急千金要方. 서울:大成文化社. 1992: 139-48, 265-6
41
41 李時珍. 本草鋼目 北京:人民衛生出版社. 1982: 219-20.
42
42 汪詞魔. 本草備要 毫北:文光固書有限公司. 1977 : 119-20.
43
43 王清任. 監林改錯. 台北:台聯國風出版社1975: 22-4.
44
44 中醫研究院編. 中間症狀如別診斷學. 北京:人民 衛生山版社. 1987:73-4.
45
45 康舜株. 바른 方劑學. 서울:大星文化社 1996:138-9.
46
46 龔廷賢.增補出病回可春.서울:一中社1994:229-30.
47
47 方賢. 奇效良方. 香港. 商務印吉館. 1977:880-7
48
48 李挺醫學入門(三卷). 서울:大星文化社 1984:180-2.
49
49 陳士鐸.石室秘錄吋告.서울:文化社1993 :148-9.
50
50 梁頌名. 中藥方劑學廣東:廣東科技出版社. 1991 :679-81, 637-9.
51
51 王錦之.方劑學:貴州:貴州支付iI版祉. 1991:238 -41.
52
52 張恩勤, 鄭貴力.方劑學.北京:科學出版社1992: 206-9.
53
53 Nag S,Tang F.Cholinergic lesions of the rat brain by ibotenic acid and 192 IgG-saporin; effects on somatostatin,substance P and neuropeptide Y levels in the cerebral cortex and the hippocampus. Neurosci Lett. 1998;14:252(2):83-6.
54
54 Hung et al. Ibotenic acid-induced lesions of the medial septum increase hippocampal membrane associated protein kinase C activity and reduce acetylcholine synthesis. Prevention by a phosphatidylcholine/ vitamin B12 diet.J.Nurt.Biochem. 2000;11:159-164.
55
55 Sarkisian MR, Tandon P,Liu Z, Yang Y, Hori A, Holmes GL et al. Multiple kainic acid seizures in the immature and adult brain. ictal manifestations and long-term effects on learning and memory. Epilepsia. 1997;38(11):1157-66.
56
56 Stubley-Weatherly L, Harding JW,Wright JE. Effects of discrete kainic acid-induced hippocampal lesions on spatial and cintextual learning and memory in rats. Brain Res. 1996: 15;716(1-2): 23-34.
57
57 Janis LS, Glasier MM, Fulop Z, Stein DG. Intraseptal injection of 192 IgG saporin produce deficits for strategyselection in spatial-memory tasks. Behav Brain Rs. 1998;90(1):23-34.
58
58 Shen J, Barnes CA, Wenk Gl, McNaughton BL. Differential effects of selective immunotoxic lesions of medial septal cholinergic cells in spatial working and reference memory. Behav Neurosci. 1996;110(5):1181-6.
59
59 Wrenn CC, Wiley RG. The behavioral functions of the cholinergic basalforebrain; lession from 192 IgG-saporin. Int J Dev Neurosci. 1998;16 (7-8):595-602.
60
60 Mizoguchi K, Yuzurihara M, Ishige A, Sasaki H, Chui DH, Tabira T. Choronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction. J Neurosci. 2000;20(4):1568-74.
61
61 Olton DS. Maze,Map and Memory. American Psychologist. 1979;34:583-96.
62
62 Olton DS, Samuelson,RJ. Remembrance of places passed, Spatial memory in rats. Journal of Experimental Psychology. Animal Behavior Processes. 1976;2:97-116.
63
63 Olton DS, Collison C. Intramaze cues and “odor trials” fail to direct choice behavior on an elevated maze. American Learning and Behavior. 1979;7: 221-3.
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