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- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effects of Boyangmaksung-bang (BYMSB) on the Membranous Nephropathy Induced by Cationic Bovine Serum Albumin in Mouse Model
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2009, v.30 no.2, pp.63-78
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(2009). Effects of Boyangmaksung-bang (BYMSB) on the Membranous Nephropathy Induced by Cationic Bovine Serum Albumin in Mouse Model. Journal of Korean Medicine, 30(2), 63-78.
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Abstract
Objective:The purpose of experimental study was to prove the effects of Boyangmakseong-bang (BYMSB) treatment on cBSA-induced in a MN mouse model. Methods:We divided mice into 4 groups. The Normal group had no treatment. We used cBSA and induced MN mouse model to the other 3 groups. The Control group was treated with cBSA (9㎎/㎏ i.p) only. The second group, named ‘BY-250’, was treated with cBSA (9㎎/㎏ i.p) and BYMSB extract (250㎎/㎏, p.o). The third group, named ‘BY-500’, was treated with cBSA (9㎎/㎏ i.p) and BYMSB extract (500㎎/㎏, p.o). After cBSA and BYMSB extract treatment for 4 weeks, the increase in percentage of body weight, proteinuria, serum albumin, total cholesterol, creatinine and BUN of all groups were measured. The CD3+, CD19+, CD4+, CD8+ cell levels of spleen of all groups were analyzed. IgA, IgG, IgM, IL-1β, TNF-α, IL-6 and IFN-γ levels of all groups were gauged. H&E staining, immunofluorescence staining and electron microscopy of kidney were observed. Results:BYMSB showed significant decrease in the 24hrs proteinuria, serum total cholesterol, serum IgG levels and BUN levels, and showed significant increase in the serum albumin levels compared with the control group. BYMSB showed increase in the increasing percentage of body weight and IFN-γ levels compared with the control. BYMSB showed decrease in the CD3+ T cells, CD4+ Th cells, IL-1β, TNF-α and IL-6 levels, but did not show significant change compared with the control. BYMSB showed considerable decrease in the thickening of the GBM on H&E staining, deposition of IgG on immunofluorescence staining and deposition of electron-density on electron microscopy of kidney compared with the control. Conclusions:According to the above results, it is suggested that BYMSB decreases the symptoms of MN induced by cBSA in a mouse model. Therefore BYMSB seems to be applicable to MN in clinical practice.
- keywords
- Boyangmakseong-bang (BuYangMoXing-fang), membranous nephropathy (MN), cationic bovine serum albumin (cBSA)
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