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芒硝의 瀉下作用이 MCAO 흰쥐의 腦浮腫에 미치는 영향

Effect of Purgative Action with Natrii Sulfas on Brain Edema of MCAO Rats

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2009, v.30 no.5, pp.77-87
강호창 (경희대학교)
김범회 (동의대학교)
심은섭 (경희대학교)
강일환 (경희대학교)
김성준 (경희대학교)
강희 (경희대학교)
손낙원 (경희대학교)
강호창, 김범회, 심은섭, 강일환, 김성준, 강희, & 손낙원. (2009). 芒硝의 瀉下作用이 MCAO 흰쥐의 腦浮腫에 미치는 영향. 대한한의학회지, 30(5), 77-87.
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Abstract

Objectives:This study aimed to evaluate the effect of purgation therapy with Natrii sulfas, an oriental medical therapy for stroke patients with constipation, on physiological indexes and the brain edema of rats. Methods:Brain edema was induced by the middle cerebral artery occlusion (MCAO); Natrii sulfas was administered once after the MCAO. At 3, 6, 15, 24, 48 hours after reperfusion, physiological indexes such as fecal weight, urine volume and water content in stool were assessed, and at 48 hours after reperfusion the edema index was measured. Results: 1.Purgation therapy with Natrii sulfas significantly improved the reduction of fecal weight caused by ischemic insult (P<0.05). 2.Purgation therapy with Natrii sulfas significantly improved the reduction of urine volume caused by ischemic insult (P<0.05). 3.Purgation therapy with Natrii sulfas significantly improved the reduction of water content in stool caused by ischemic insult (P<0.05). 4.Purgation therapy with Natrii sulfas did not improve the neurological symptom caused by ischemic insult. 5.Purgation therapy with Natrii sulfas did not attenuate the total infarct volume caused by ischemic insult. 6.Purgation therapy with Natrii sulfas attenuated the brain edema caused by ischemic insult (P<0.05). Conclusions:These results suggest that purgation therapy with Natrii sulfas improves some important symptoms and has a protective effect on the brain edema caused by ischemic insult.

keywords
Natrii sulfas, middle cerebral artery occlusion, brain edema, purgation


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