- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effect of Purgative Action with Natrii Sulfas on Brain Edema of MCAO Rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2009, v.30 no.5, pp.77-87
&
(2009). Effect of Purgative Action with Natrii Sulfas on Brain Edema of MCAO Rats. Journal of Korean Medicine, 30(5), 77-87.
- Downloaded
- Viewed
Abstract
Objectives:This study aimed to evaluate the effect of purgation therapy with Natrii sulfas, an oriental medical therapy for stroke patients with constipation, on physiological indexes and the brain edema of rats. Methods:Brain edema was induced by the middle cerebral artery occlusion (MCAO); Natrii sulfas was administered once after the MCAO. At 3, 6, 15, 24, 48 hours after reperfusion, physiological indexes such as fecal weight, urine volume and water content in stool were assessed, and at 48 hours after reperfusion the edema index was measured. Results: 1.Purgation therapy with Natrii sulfas significantly improved the reduction of fecal weight caused by ischemic insult (P<0.05). 2.Purgation therapy with Natrii sulfas significantly improved the reduction of urine volume caused by ischemic insult (P<0.05). 3.Purgation therapy with Natrii sulfas significantly improved the reduction of water content in stool caused by ischemic insult (P<0.05). 4.Purgation therapy with Natrii sulfas did not improve the neurological symptom caused by ischemic insult. 5.Purgation therapy with Natrii sulfas did not attenuate the total infarct volume caused by ischemic insult. 6.Purgation therapy with Natrii sulfas attenuated the brain edema caused by ischemic insult (P<0.05). Conclusions:These results suggest that purgation therapy with Natrii sulfas improves some important symptoms and has a protective effect on the brain edema caused by ischemic insult.
- keywords
- Natrii sulfas, middle cerebral artery occlusion, brain edema, purgation
Reference
1
1 전국한의과대학 본초학교수 공저. 본초학. 서울:영림사. 1994:244-5.
2
2 Hwang CW, Byun I. A Literatual study on the Emergency care and Administration method of Medical emergency. Hye Hwa Medicine. 1994;1(3):16-45.
3
3 김영석. 임상중풍학. 서울:서원당. 1997:303-48.
4
4 Koo BS, Lee DS, Moon SK, Go CN, Cho KH, Bae HS, Lee KS, Kim YS. Effects of Daeseungkitang on Constipated Stroke Patients. The Journal of Korean Oriental Medicine. 2000;21(2):3-13.
5
5 申錦林, 陳評, 趙安氏, 劉日煊, 李宏云, 陽志運. 黃液直腸摘注治療急性腦出血的療效觀察. 中醫藥 硏究.1998;14(1):27-8
6
6 Fisher M. Characterizing the target of acute stroke therapy. Stroke. 1997;28(4):866-72.
7
7 서울대학교의과대학. 신경학원론. 서울:서울대학교출판부. 1998:178-88, 339-49, 521-50.
8
8 Cho KH. Medical Management of Spontaneous Intracerebral Hemorrhage. Korean Journal of Stroke. 2003:5(1):26-9.
9
9 Alberts MJ. Diagnosis and treatment of ischemic stroke. Am J Med. 1999;106(2):211-21.
10
10 Lee Won Chul. Research on the Xiafa used at the acute stages of Stroke. The Jounal of Korean Oriental Medicine. 1998;19(1):385-90.
11
11 Im SU. The Clinical Evaluation of Defecation in Stroke Patients. Journal of Korea Institute of Oriental Medical Informatics. 1997;3(1)7-11.
12
12 Alberts MJ. Treatment of acute ischemic stroke. J Stroke Cerebrovasc Dis. 2001;10(2 Pt 2):10-7.
13
13 김완희. 한의학원론. 서울:성보사. 1982:398, 402-4, 506-8.
14
14 Son DH, Jo GH, Kim YS, Bae HS, Lee GS, Lee YG. The Comparison Study on the Effect of Bowel Movement between Bo-Ryu Enema(Bao-Liu Enema) and General Enema in Patients at the Acute Stage of Cerebrovascular Accident. The Journal of Korean Oriental Medicine. 2001;22(3):51-62.
15
15 대한내과학회 해리슨내과학 편집위원회. 해리슨내과학. 서울:도서출판 MIP. 2003;252.
16
16 Bharucha AE. Constipation. Best Pract Res Clin Gastroenterol. 2007;21(4):709-31.
17
17 Ullman T, Reding M. Gastrointestinal dysfunction in stroke. Semin Neurol. 1996;16(3):269-75.
18
18 Winge K, Rasmussen D, Werdelin LM. Constipation in neurological diseases. J Neurol Neurosurg Psychiatry. 2003;74(1):13-9.
19
19 Johanson JF, Sonnenberg A, Koch TR, McCarty DJ. Association of constipation with neurologic diseases. Dig Dis Sci. 1992;37(2):179-86.
20
20 Camilleri M, Bharucha AE. Gastrointestinal dysfunction in neurologic disease. Semin Neurol. 1996;16(3):203-16.
21
21 Han TR. Prognostic Evaluation in Stroke Rehabilitation. Journal of Korean Academy of Rehabilitation Medicine. 1997;21(5):817-25.
22
22 Chakrabarti SD, Ganguly R, Chatterjee SK, Chakravarty A. Squatting, blood pressure and stroke. J Assoc Physicians India. 2002;50:382-6.
23
23 Krogh K, Christensen P, Laurberg S. Colorectal symptoms in patients with neurological diseases. Acta Neurol Scand. 2001;103(6):335-43.
24
24 Indredavik B, Bakke F, Slordahl SA, Rokseth R, Hâheim LL. Treatment in a combined acute and rehabilitation stroke unit: which aspects are most Important? Stroke. 1999;30(5):917-23.
25
25 Bhalla A, Wolfe CD, Rudd AG. Management of acute physiological parameters after stroke. QJM. 2001;94(3):167-72.
26
26 Modo M, Stroemer RP, Tang E, Veizovic T, Sowniski P, Hodges H. Neurological sequelae and long-term behavioural assessment of rats with transient middle cerebral artery occlusion. J Neurosci Methods. 2000;104(1):99-109.
27
27 Lee CZ, Litt L, Hashimoto T, Young WL. Physiologic monitoring and anesthesia considerations in acute ischemic stroke. J Vasc Interv Radiol. 2004;15(1 Pt 2):S13-9.
28
28 Perkin GD, Murray-Lyon I. Neurology and the gastrointestinal system. J Neurol Neurosurg Psychiatry. 1998;65(3):291-300.
29
29 Paczynski RP, Venkatesan R, Diringer MN, He YY, Hsu CY, Lin W. Effects of fluid management on edema volume and midline shift in a rat model of ischemic stroke. Stroke. 2000;31(7):1702-8.
30
30 Pulsinelli W. Pathophysiology of acute ischaemic stroke. Lancet. 1992;339(8792):533-6.
31
31 Ting P, Masaoka H, Kuroiwa T, Wagner H, Fenton I, Klatzo I. Influence of blood-brain barrier opening to proteins on development of post-ischaemic brain injury. Neurol Res. 1986;8(3):146-51.
32
32 Klatzo I. Blood-brain barrier and ischaemic brain oedema. Z Kardiol. 1987;76:67-9.
33
33 Klatzo I. Pathophysiological aspects of brain edema. Acta Neuropathol. 1987;72(3):236-9.
34
34 Kuroiwa T, Ting P, Martinez H, Klatzo I. The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion. Acta Neuropathol. 1985;68(2):122-9.
35
35 Kuroiwa T, Cahn R, Juhler M, Goping G, Campbell G, Klatzo I. Role of extracellular proteins in the dynamics of vasogenic brain edema. Acta Neuropathol. 1985;66(1):3-11.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- A Study of Reports about Dizziness Reaction -Focus on the China Academic Journal-
- A Report on a Crosstabulation Analysis of a Body Composition Test of Workers
- An Analysis of Saengmaegsan’s Ingredients and a Comparison Study on Anti-Oxidation Effects According to Kinds of Extract
- Study for Patterns of Antioxidative-related Studies using Herbal Plants
- Antitumor Effect of Hang-Am-Dan (HAD) and its Ingredients on Calu6 and MCF-7 Human Cancer Cell Lines
- Effects of Scutellaria Radix Extract on the Membranous Nephropathy Induced by Cationic Bovine Serum Albumin in Mouse Model
- Effect of Purgative Action with Natrii Sulfas on Brain Edema of MCAO Rats
- Psychological Characteristics of Infant Outpatients and their Parents in Korean Traditional Clinic
- Repeated Dose 4-Week Oral-Treatment for DRF Toxicity Test of HMC05 in Sprague-Dawley Rats
- Randomized Clinical Controlled Trials with Herbal Acupuncture (Pharmacopuncture) in Korea - A Systematic Review
- Overview of Diabetic Peripheral Neuropathy and Need for Therapeutic Strategy using Traditional Korean Medicine
- A Retrospective Study on the Influence of Kamisoyo-san (Jiaweixiaoyao-san) on Improving Ovarian Function in Child-bearing Period Infertile Women with Ovarian Dysfunction
- Antioxidative Activities of Wen-pi-tang-Hab-Wu-ling-san (WHW®) in vitro
- A Case Report of Regressed Metastatic Brain Tumors and Prolongation of Life with Allergen Removed Rhus verniciflua Stokes after Gamma Knife Radiosurgery
- Clinical Analysis of 312 Patients with Hepatobiliary Cancer in Oriental Hospital
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.