- P-ISSN 1010-0695
- E-ISSN 2288-3339
Objectives:This study was performed to elicit the effectiveness of a herbal formula, Kamisoyo-san (Jiaweixiaoyao- san) on enhancing ovarian function in infertile woman with ovarian dysfunction. Methods:28 patients who initially visited between November 2006 and February 2009 and were administered Kamisoyo-san until May 2009 were retrospectively evaluated for their ovarian function by means of basal FSH (b-FSH), menstrual cycle, body mass index (BMI), and body fat ratio. To identify the major factor of improving ovarian function, 28 patients were classified into two groups by criteria of patent factors, such as pre-administration b-FSH, patient age, and treatment duration, respectively. Two groups were compared in terms of pregnancy percentage, b-FSH, menstrual cycle, BMI, and body fat ratio. Results:Post-administration b-FSH significantly decreased in comparison with pre-administration (p=0.004). The higher group (b-FSH ≥ 25mIU/mL) in pre-administration b-FSH was more effective in decrease of post-administration b-FSH than the lower one (10mIU/mL < b-FSH < 25mIU/mL). Conclusion:Kamisoyo-san may have a therapeutic effect on the infertility of child bearing period woman with ovarian dysfunction.
Jonathan SB, Eli YA, Paula AH. Novak’s Gynecology, 12th Ed. Baltimore:Williams & Wilkins. 1996:916-7.
Lee JY. Reproductive Endocrinology. Seoul:Seoul National University Press. 2002:13-4.
Jee BC. The usefulness of evaluation method in ovarian function. J Korean Obstetrics and Gynecol. 2008:65-6.
Sin GS, Sin YW, Jeong JH, Lee BR. Clinical case study on the effect of Danchisoyo-san utilizing for menopause. The Journal of Oriental Obstetrics and Gynecology. 2003;16(4):77-82.
Kim DI, Woo DY, Seo JW, Lee TK. The management of climacteric syndrome clinic and the herbal medicine for that clinic. The Journal of Oriental Gynecology. 2000;13(2):418-36.
Korea National Statistical Office. The social index of Republic of Korea in 2008. Seoul:Korea National Statistical Office. 2008:94.
te Velde ER, Scheffer GJ, Dorland M, Broekmans FJ, Fauser BC. Developmental and endocrine aspects of normal ovarian aging. Mol Cell Endocrinol 1998;145:67-73.
Dei M, Seravalli V, Bruni V, Balzi D. Pasqua A. Predictors of recovery of ovarian function after weight gain in subjects with amenorrhea related to restrictive eating disorders. Gynecol Endocrinol. 2008;24(8):459-64.
Takeuchi T, Tsutsumi O, Iketzuki Y, Takai Y, Taketani Y. Positive Relationship between Androgen and the Endocrine Disruptor, Bisphenol A, in Normal Women and Women with Ovarian Dysfunction. Endocrinol J. 2004;51(2):165-9.
Chen SW. The formula book edited by greatly peaceful benefiting the people office (TaiPing- HuiMinHeJiJuFang). Beijing:People’s medical publishing house. 1985:308.
Xue J. Summary on Essentials in Internal Medicine (NeiKeZhaiYao). Beijing:People’s medical publishing house. 1983:60.
Park CS, Sohn YJ. A Study on the Effects of Gamisoyo-san on Ovariectomized Osteoporosis in Rats. The Journal of Oriental Obstetrics and Gynecology. 2008;27(1):1-15.
Kim SH, Cho JH, Jang JB, Lee KS. A case report of managing the premature ovarian failure patient. The Journal of Oriental Obstetrics and Gynecology. 2003;16(3):194-9.
David HB, Andrea W, Norbert G. Comparing anti-Müllerian hormone (AMH) and folliclestimulating hormone (FSH) as predictors of ovarian function. Fertil Steril. 2008;91(4):1553-5.
Grynberg M, Feyereisen E, Scheffer JB, Koutroubis P, Frydman R, Fanchin R. Early follicle development alters the relationship between antral follicle counts and inhibin B and folliclestimulating hormone levels on cycle day 3. Fertil Steril. 2008; in press.
Korean Society for the Study of Obesity. Clinical Obesity, 2nd Ed. Seoul:Korea Medical Book Publisher. 2001:215-9.
Robker RL, Akison LB, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderateweight women. J Clin Endocrinol Metab. 2009. May;94(5):1533-40.
Rose E. Body fat, puberty, and fertility. Biological Reviews. 2008;59(2):161-8.
Choi EM, Heo JW, Kim SR, Kang MJ. A clinical study on infertility with premature ovarian failure. The Journal of Oriental Gynecology. 2001;14(1):393-408.