- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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A Trend of Yin-tonifying Formulas Compared with Yang-tonifying Formulas on Anti-platelet and Anti-thrombotic Activity
대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2009, v.30 no.6, pp.1-8
(Korea Institute of Oriental Medicine)
(Korea Institute of Oriental Medicine)
(Korea Institute of Oriental Medicine)
(Korea Institute of Oriental Medicine)
(Korea Institute of Oriental Medicine)
(한국한의학연구원)
(Korea Institute of Oriental Medicine)
(Korea Institute of Oriental Medicine)
(Korea Institute of Oriental Medicine)
(Korea Institute of Oriental Medicine)
(한국한의학연구원)
Won,
K.
J.
,
Bo,
K.
Y.
,
Sang,
Y.
A.
,
Ju,
H.
L.
,
Sang,
W.
A.
,
&
고병섭.
(2009). . 대한한의학회지, 30(6), 1-8.
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Abstract
Objectives:Formulas for treatment of yin or yang deficiency conditions have been commonly used in traditional Korean medicine. The aim of this study is to examine the possible inhibitory effects of yin- or yang-tonifying formulas on in vivo anti-platelet activity and in vivo anti-thrombotic activity. Methods:We tested the effects of 26 types of yin- or yang-tonifying formulas on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry and accessed a biomarker of platelet activation using thromboxane B2 immunoassay. We also tested the anti-thrombotic effects of effective candidates on experimental models of thrombosis in mice. Results:3 types of yin-tonifying formulas and 3 types of yin-yang-tonifying formulas were selected to be the most effective candidates (p<0.01). Also, through in vivo study, the antithrombotic activities of Igyeong-tang, Gamisipjeondaebo-tang, and Gamisoyo-san-treated groups, with recovery rate of 60, 50, and 45.45%, respectively, were observed to be higher than those of the control group (saline, 36.8%) in mouse acute thrombosis. Conclusion:These results show that yin-tonifying formulas are more effective in anti-platelet and anti-thrombotic activity than yang-tonifying formulas.
- keywords
- formulas, tonifying, yin, yang, platelet aggregation, antithrombotic
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