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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Comparative Study of Extraction Solvents on the Anti-inflammatory Effects of Scutellaria baicalensis

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2009, v.30 no.6, pp.44-52

Myeong Sook Cheon (Korea Institute of Oriental Medicine)
Seung Ju Kim (Korea Institute of Oriental Medicine)


Jin Mi Chun (Korea Institute of Oriental Medicine)


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Abstract

Objectives:This study was performed to evaluate the influence of different extracting solvents (water, methanol, ethanol, or n-hexane) on the anti-inflammatory efficacy of Scutellaria baicalensis (Lamiaceae), which has been used widely as a traditional herbal medicine for its anti-inflammatory properties. Methods:The ability of each extract to inhibit the production of pro-inflammatory mediators such as NO, TNF-α, and PGE2 by lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells was measured. Results:The results showed that extraction solvents (except n-hexane) for S. baicalensis showed significant inhibitory effects on NO, TNF-α and PGE2 production. Especially, methanol was the solvent with the greatest activity against NO and PGE2 production. However, there was no difference between the extracts for inhibitory activity of TNF-α. Conclusion:The present study suggests that methanol is a superior extraction solvent than water, ethanol, or n-hexane for maintaining the anti-inflammatory effects of S. baicalensis.

keywords
Scutellaria baicalensis, anti-inflammatory, extracting solvent, NO, TNF-α, PGE2


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