- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Synergic Effect of GamiSamgieum (SGMX) and Lipitor on Hyperlipidemia in Animal Model
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2009, v.30 no.6, pp.103-111
(Daejeon University)
(Daejeon University)
(Daejeon University)
(Daejeon University)
(Daejeon University)
Hye-Jung,
P.
, In-Chan,
S.
, &
(2009). Synergic Effect of GamiSamgieum (SGMX) and Lipitor on Hyperlipidemia in Animal Model. Journal of Korean Medicine, 30(6), 103-111.
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Abstract
Objectives:To investigate the possibility of GamiSamgieum (SGMX) as a combination therapy with statins on hyperlipidemia using an animal model. Methods:Forty eight ICR mice (male) were divided into six groups of eight mice each: naive, induced, Lipitor 5 mg/kg, Lipitor 5 mg/kg plus SGMX 100 mg/kg, Lipitor 10 mg/kg, and Lipitor 10 mg/kg plus SGMX mg/kg treatment group. Hyperlipidemia was induced by feeding a purified high fat diet for all groups (except naive) along with treatment of drugs for 6 weeks, and then biological parameters were examined on the last experiential day. Results:Lipitor treatment lowered total cholesterol and increased HDL-cholesterol compared to the induced group with no statistical significance. However, co-treatment of SGMX with Lipitor revealed synergic effects on total cholesterol and HDL-cholesterol significantly (P < 0.05) in both. SGMX co-treatment also significantly protected liver tissues from the oxidative stress in liver tissues (P < 0.05) and augmented inhibitory effect of Lipitor against fat accumulation in the body. Conclusion:These results indicate the possibility of that SGMX can be used for patients having hyperlipidemia as a combination therapy with statin drugs
- keywords
- hyperlipidemia, SGMX, Lipitor, cholesterol, traditional Korean medicine
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