Article Detail

Home > Article Detail
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Review of Randomized Controlled Trials using Herbal Remedies on Cancer Patients

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2010, v.31 no.5, pp.12-32

WANG JINGHUA


  • Downloaded
  • Viewed

Abstract

Objective: This study aimed to review herbal remedy-based RCTs on cancer patients in order to produce helpful information for clinical study of herbal medicine in the future. Methods: We collected all RCTs using herbal remedies on cancer patients from Pubmed and Cochrane databases until November 1st, 2009. Elementary information such as nation where performed, clinical question, design, randomization, double-blinding and allocation concealment were analyzed. Results: 153 RCTs were finally selected. 119 RCTs were conduced in China while only 2 were done in Korea. The most frequent targeted cancer was lung cancer as 29 RCTs. The main clinical questions included improvement of quality of life, elongation of survival rate and regression of tumor being 83, 62 and 55 respectively. 112 RCTs used herbal remedies with western therapy. Adequate methods for randomization and allocation concealment were found in 37% and 10% of trials respectively. Conclusions: We found that herbal remedies are used on cancer patients in aspects of both caring for the human body and tumor treatment itself. The study might provide us useful data for cancer-related clinical study using herbal remedies in the future.

keywords
Herbal medicine, traditional Korean medicine, cancer, randomized clinical trial


Reference

1

1 Han Q, Kong X, Zhao Y, Li Z. TCM treatment of chemotherapy-induced fever in leukemia patients. J Tradit Chin Med. 1998;18(2):91-3.

2

2 Wei YF, Du HL, Wang SY. Study on efficacy of treatment of acute leukemia by shengfu injection in combination with chemotherapy and the effect on cellular immunity, serum interleukin-6 and tumor necrosis factor-alpha levels. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003;23(4):258-60.

3

3 Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, et al. All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 2004; 101(15):5328-35.

4

4 Ma M. Clinical observation on effect of combined therapy of pamidronati sodium and shenfu injection in treating multiple myeloma caused ostealgia. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004;24(1):67-8.

5

5 Xu RR, Cao F, Liu ZX. Clinical observation on treatment of acute myelocytic leukemia by supplementing qi, nourishing yin and clearing heat principle. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004;24(5):411-4.

6

6 Wang B, Liu X, Fu X. Clinical observation on effect of yiqi huoxue decoction in comprehensive treatment on advanced stage of esophageal cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999;19(10):589-91.

7

7 Gao XP, Zhao WX, Zhang ZL. Effect of huangqi zengmian powder on interstitial response in patients with esophageal cancer at peri-operational period. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(3):171-3.

8

8 Lu P, Liang QD, Li R, Niu HR, Kou XG, Xi HJ. Effect of traditional chinese medicine on survival and quality of life in patients with esophageal carcinoma after esophagectomy. Chin J Integr Med. 2006;12(3):175-9.

9

9 Wang JY, Ma GW, Dai SQ, Rong TH, Wang X, Lin P, et al. Effect of cellular immune supportive treatment on immunity of esophageal carcinoma patients after modern two-field lymph node dissection. Ai Zheng. 2007;26(7):778-81.

10

10 Zhao JX, Li XF, Wang XX. Effects of bodyresistance strengthening and tumor-suppressing granules on immune adhesion function of red blood cells and expression of metastasis protein CD44 in tumor cells of patients with esophageal carcinoma. World J Gastroenterol. 2007;13(32) :4360-4.

11

11 Zheng Y. The therapeutic effects of rehmannia oral liquid for the syndrome of heat accumulation with Yin consumption in esophagus cancer patients undergoing radiotherapy--a report of 60 cases. J Tradit Chin Med. 2007;27(4):248-54.

12

12 Wang B, Liu X, Wu Z. Effect of qi replenishing and blood circulation activating drugs in treatment of middle-advanced pancreatic cancer with radio- and chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20(10):736-8.

13

13 Zemskov VS, Procopchuk OL, Susak YM, Zemskov SV, Hodysh YY, Zemskova MV. Ukrain (NSC-631570) in the treatment of pancreas cancer. Drugs Exp Clin Res. 2000;26 (5-6):179-90.

14

14 Gansauge F, Ramadani M, Pressmar J, Gansauge S, Muehling B, Stecker K, et al. NSC-631570 (Ukrain) in the palliative treatment of pancreatic cancer. Results of a phase II trial. Langenbecks Arch Surg. 2002;386(8):570-4.

15

15 Zemskov V, Prokopchuk O, Susak Y, Zemskov S, Tkachenko O, Hodysh Y, et al. Efficacy of ukrain in the treatment of pancreatic cancer. Langenbecks Arch Surg. 2002;387(2):84-9.

16

16 Zhang Q, Wang XM, Chi HC. Effects of Guben Yiliu II combined with arterial perfusion with chemotherapeutic agent in treating advanced pancreatic cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(5):400-3.

17

17 Lenartz D, Stoffel B, Menzel J, Beuth J. Immunoprotective activity of the galactosidespecific lectin from mistletoe after tumor destructive therapy in glioma patients. Anticancer Res. 1996;16(6B):3799-802.

18

18 Lenartz D, Dott U, Menzel J, Schierholz JM, Beuth J. Survival of glioma patients after complementary treatment with galactosidespecific lectin from mistletoe. Anticancer Res. 2000;20(3B):2073-6.

19

19 Goebell PJ, Otto T, Suhr J, Rübben H. A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs. 2002;25 (6):442-51.

20

20 Oh WK, Kantoff PW, Weinberg V, Jones G, Rini BI, Derynck MK, et al. Prospective, multicenter, randomized phase II trial of the herbal supplement, PC-SPES, and diethylstilbestrol in patients with androgen-independent prostate cancer. J Clin Oncol. 2004;22(18):3705-12.

21

21 Grossarth-Maticek R, Ziegler R. Prospective controlled cohort studies on long-term therapy of cervical cancer patients with a mistletoe preparation (Iscador). Forsch Komplementmed. 2007;14(3):140-7.

22

22 Grossarth-Maticek R, Ziegler R. Prospective controlled cohort studies on long-term therapy of ovairian cancer patients with mistletoe (Viscum album L.) extracts iscador. Arzneimittelforschung. 2007;57(10):665-78.

23

23 Quan D, Lu Y, Li Z. Clinical observation on radio- or chemotherapy plus Traditional Chinese medicine in treating brain metastatic tumor. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999;19 (7):392-4.

24

24 Hong J, Xiangwei W, Yanping C, Qionghui L, Wen L. An analysis of the long-term therapeutic effect of the integrated therapy of traditional Chinese medicine and radiotherapy on abdominal malignant tumor. J Tradit Chin Med. 2005;25 (2):125-8.

25

25 Liu L, Ding Q, Dai XF. Study on the controlling effect of Shenqi Fuzheng injection on plasma cytokine network in patients with thoracic tumor undergoing radiotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(12):1082-5.

26

26 Williams MS, Burk M, Loprinzi CL, Hill M, Schomberg PJ, Nearhood K, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys. 1996;36 (2):345-9.

27

27 Wang HZ, Lin ZT. Clinical study on effect of kang' aibao oral liquid in treating 103 malignant tumor patients. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997;17(12):730-2.

28

28 Tan D, Xie Z, Zhong M. A clinical observation on the leukopenia treated with shengbaikuai decoction. Zhongguo Zhong Xi Yi Jie He Za Zhi.1998;18(7):408-10.

29

29 Li J, Li X, Li J. Clinical and experimental study on Fuzheng Baozhen Decoction enhancing effect of radio- and chemotherapy for malignant tumors. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998;18(9):523-6.

30

30 Xin M, Wang J, Zhou C. Clinical study on Shenqi Fuzheng injection combined with chemotherapy in treating malignant tumor of digestive tract. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998;18(11):658-61.

31

31 Liu J, Yu RC, Rao XQ. Study on effect of moxibustion and guben yiliu III combined with chemotherapy in treating middle-late stage malignant tumor. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(4):262-4.

32

32 Xu ZY, Zhu YW, Zhou WD. Clinical and experimental study on effect of shuanghuang shengbai granule on myelosuppression induced by chemotherapy and ultrastructure observation of bone marrow in mice. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(5):328-31.

33

33 Li XR, Zhou YF, Jiao ZH. Clinical study on post-operational anti-metastasis effect of xiaoliu pingyi mixture. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(5):335-8.

34

34 Jiang CM, Pang MR, Gong LY. Clinical observation on effect of chemotherapy combined with Chinese medicine in treating advanced tumor patients and on immunologic parameters. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(12):885-7.

35

35 Olsen DL, Raub W Jr, Bradley C, Johnson M, Macias JL, Love V, et al. The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncol Nurs Forum. 2001;28 (3):543-7.

36

36 Grossarth-Maticek R, Kiene H, Baumgartner SM, Ziegler R. Use of Iscador, an extract of European mistletoe (Viscum album), in cancer treatment: prospective nonrandomized and randomized matched-pair studies nested within a cohort study. Altern Ther Health Med. 2001;7(3): 57-66, 68-72, 74-6.

37

37 Liu J, Yu RC, Tang WJ. Influence of combined therapy of guben yiliu III, moxibustion and chemotherapy on immune function and blood coagulation mechanism in patients with mid-late stage malignant tumor. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002;22(2):104-6.

38

38 Duan P, Wang ZM. Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002;22(7):515-7.

39

39 Zhang B, Hu PL, Qiu HJ, Qian SY, Chen XX, Huang GX. Observation of clinical response of "sheng ban recipe" for platelets decrease after chemotherapy. Zheng. 2004;23(11 Suppl):1470-2.

40

40 Piao BK, Wang YX, Xie GR, Mansmann U, Matthes H, Beuth J, et al. Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Anticancer Res. 2004;24(1):303-9.

41

41 Pan B, Cheng T, Nan KJ, Qiu GQ, Sun XC. Effect of Fuzheng Yiliu decoction combined with chemotherapy on patients with intermediate and late stage gastrointestinal cancer. World J Gastroenterol. 2005;11(3):439-42.

42

42 Liu Y, Ye F, Qiu GQ, Zhang M, Wang R, He QY, et al. Effects of lactone I from Atractylodes macrocephala Koidz on cytokines and proteolysis-inducing factors in cachectic cancer patients. Di Yi Jun Yi Da Xue Xue Bao. 2005; 25(10):1308-11.

43

43 Wu MH, Zhou XP, Cheng HB. Clinical study on aitongping capsule in treating cancerous pain. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;25(3):218-21.

44

44 Kim JH, Park CY, Lee SJ. Effects of sun ginseng on subjective quality of life in cancer patients: a double-blind, placebo-controlled pilot trial. J Clin Pharm Ther. 2006;31(4):331-4.

45

45 Wang ZY, Li GS, Huang HX. Clinical observation on treatment of 75 mid-late stage cancer patients with yanshu Injection. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26(8):681-4.

46

46 Zhang T, Ma SL, Xie GR, Deng QH, Tang ZZ, Pan XC, et al. Clinical research on nourishing yin and unblocking meridians recipe combined with opioid analgesics in cancer pain management. Chin J Integr Med. 2006;12(3):180-4.

47

47 Pan YL, Pan YZ. Observation on effects of Zhiling Capsule in treating 400 patients with various types of cancer in mid-ad-vanced stage. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27 (9):807-9.

48

48 Ma H, Zhang X, Bai M, Wang X. Clinical effects of lianbai liquid in prevention and treatment of dermal injury caused by radiotherapy. J Tradit Chin Med. 2007;27(3):193-6.

49

49 Wu TH, Chiu TY, Tsai JS, Chen CY, Chen LC, Yang LL. Effectiveness of Taiwanese traditional herbal diet for pain management in terminal cancer patients. Asia Pac J Clin Nutr. 2008;17(1): 17-22.

50

50 Lissoni P, Rovelli F, Brivio F, Zago R, Colciago M, Messina G, et al. A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer. In Vivo. 2009;23(1):171-5.

51

51 Zhuang SR, Chen SL, Tsai JH, Huang CC, Wu TC, Liu WS, et al. Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/ radiotherapy. Phytother Res. 2009;23(6):785-90.

52

52 Liu CL, Wang YD, Jin XJ. Clinical observation on treatment of non-small cell lung cancer with Chinese herbal medicine combined with bronchial arterial infusion chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(8):579-81.

53

53 Ernst E, Schmidt K, Steuer-Vogt MK. Mistletoe for cancer? A systematic review of randomised clinical trials. Int J Cancer. 2003;107(2):262-7.

54

54 Ben-Arye E, Frenkel M, Margalit RS. Approaching complementary and alternative medicine use in patients with cancer: questions and challenges. J Ambul Care Manage. 2004; 27(1):53-62.

55

55 Myers C, Stuber ML, Bonamer-Rheingans JI, Zeltzer LK. Complementary therapies and childhood cancer. Cancer Control. 2005;12(3):172-80.

56

56 Shu X, McCulloch M, Xiao H, Broffman M, Gao J. Chinese herbal medicine and chemotherapy in the treatment of hepatocellular carcinoma: a meta-analysis of randomized controlled trials. Integr Cancer Ther. 2005;4(3):219-29.

57

57 Andrew J. Vickers, Joyce Kuo, Barrie R. Cassileth. Unconventional Anticancer Agents: A Systematic Review of Clinical Trials. J Clin Oncol. 2006;24(1):136-40.

58

58 Efficace F, Horneber M, Lejeune S, Van Dam F, Leering S, Rottmann M, et al. Methodological quality of patient-reported outcome research was low in complementary and alternative medicine in oncology. J Clin Epidemiol. 2006;59(12): 1257-65.

59

59 Ernst E, Schmidt K, Baum M. Complementary/ Alternative therapies for the treatment of breast cancer. A systematic review of randomized clinical trials and a critique of current terminology. Breast J. 2006;12(6):526-30.

60

60 Gerber B, Scholz C, Reimer T, Briese V, Janni W. Complementary and alternative therapeutic approaches in patients with early breast cancer: a systematic review. Breast Cancer Res Treat. 2006;95(3):199-209.

61

61 Ruan WJ, Lai MD, Zhou JG. Anticancer effects of Chinese herbal medicine, science or myth? J Zhejiang Univ Sci B. 2006;7(12):1006-14.

62

62 McCulloch M, See C, Shu XJ, Broffman M, Kramer A, Fan WY, et al. Astragalus-based Chinese herbs and platinum-based chemotherapy for advanced non-small-cell lung cancer: meta-analysis of randomized trials. J Clin Oncol. 2006;24(3):419-30

63

63 Tamayo C, Diamond S. Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.). Integr Cancer Ther. 2007;6(2):146-57.

64

64 Greenlee H, Abascal K, Yarnell E, Ladas E. Clinical applications of Silybum marianum in oncology. Integr Cancer Ther. 2007;6(2):158-65.

65

65 Sood A, Barton DL, Bauer BA, Loprinzi CL. A critical review of complementary therapies for cancer-related fatigue. Integr Cancer Ther. 2007;6(1):8-13.

66

66 Xu L, Lao LX, Ge A, Yu S, Li J, Mansky PJ. Chinese herbal medicine for cancer pain. Integr Cancer Ther. 2007;6(3):208-34.

67

67 Milazzo S, Lejeune S, Ernst E. Laetrile for cancer: a systematic review of the clinical evidence. Support Care Cancer. 2007;15(6):583-95.

68

68 Machado Rocha FC, Stefano SC, De Cassia Haiek R, Rosa Oliveira LM, Da Silveira DX. Therapeutic use of Cannabis sativa on chemotherapyinduced nausea and vomiting among cancer patients: systematic review and meta-analysis. Eur J Cancer Care (Engl). 2008;17(5):431-43.

69

69 Spadacio C, Barros NF. Use of complementary and alternative medicine by cancer patients: systematic review. Rev Saude Publica. 2008;42 (1):158-64.

70

70 Meng MB, Cui YL, Guan YS, Ying Z, Zheng MH, Yuan CK, et al. Traditional Chinese medicine plus transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma. J Altern Complement Med. 2008;14(8):1027-42.

71

71 Molassiotis A, Potrata B, Cheng KK. A systematic review of the effectiveness of Chinese herbal medication in symptom management and improvement of quality of life in adult cancer patients. Complement Ther Med. 2009;17(2):92-120.

72

72 Nahleh Z, Tabbara IA. Complementary and alternative medicine in breast cancer patients. Palliat Support Care. 2003;1(3):267-73.

73

73 Schulz KF, Chalmers I, Hayes RJ, Altman DG. JAMA. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. 1995;273 (5):408-12.

74

74 Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, et al. Improving the quality of reporting of randomized controlled trials: the CONSORT statement. JAMA. 1996;276(8):637-9.

75

75 Chalmers I. Current Controlled Trials: an opportunity to help improve the quality of clinical research. Curr Control Trials Cardiovasc Med. 2000;1(1):3-8.

76

76 Korea National Statistical Office. Available from: URL:http://www.kostat.go.kr.

77

77 Ministry for Health, Welfare and Family Affairs. 암정복 2015:제2기 암정복 10개년 계획. 2006.

78

78 Braunwald E, Fauci A, Kasper D, Hauser S, Longo D, Jameson J. Harrison's Principles of Internal medicine 16th edition. Seoul:MIP. 2006: 469-75.

79

79 National Cancer Information Center. Available from :URL:http://www.cancer.go.kr

80

80 Chae BJ, Song BJ, Kim SS, Kim SK, Jun KH, Song KY, et al. Use of Complementary and Alternative Medicine by Gastric Cancer Patients. J Korean Surg Soc. 2007;72(5):369-78.

81

81 Molassiotis A, Fernadez-Ortega P, Pud D, Ozden G, Scott J, PanteliV, et al. Use of complementary and alternative medicine in cancer patients: a European survey. Annals of Oncology. 2005;16 (4):655-3.

82

82 Scottish Intercollegiate Guidelines Network. Available from:URL:http://www.sign.ac.uk/index. html

83

83 Park BK, Lee JH, Cho CK, Shin HK, Eom SK, Yoo HS. Systemic Review of Clinical Studies about Oriental Medical Treatment of Cancer in Korea. Korean J. Orient. Int. Med. 2008:29(4) 1061-74.

84

84 NCBI Pubmed. Available from:URL:http://www. ncbi.nlm.nih.gov/sites/entrez

85

85 The Cochrane Library. Available from:URL:http: //www.thecochranelibrary.com

86

86 Park JK. Oncology. Seoul:Ilchokak. 2003.

87

87 Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1-12.

88

88 Park JE, Kang KW, Choi SM. Assessing Methodological Quality of Acupuncture Clinical Trials of Korea. J Korean Acupuncture & Moxibustion Society. 2007;24(1):127-35.

89

89 Wang ZQ. Combined therapy of brain metastasis in lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992;12(10):581, 609-10.

90

90 Mi YY, Hu YJ, Zhou MZ. Study of relationship between level of serum selenium and syndrome differentiation and typing of traditional Chinese medicine in lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995;15(11):658-60.

91

91 Ren HY, Xi XP, Liao YP. Clinical and experimental observation of xilixin granule combined with radiotherapy in treating malignanttumors. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996;16(11):661-3.

92

92 Li JH. A study on treatment of lung cancer by combined therapy of traditional Chinese medicine and chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996;16(3):136-8.

93

93 Liu X, Wang B, Fu X. Clinical study on treatment of advanced non-small cell lung cancer with Chinese herbal medicine combined with synchronous radio- and chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20(6):427-9.

94

94 Fan G, Zong W, Zuo J. Dynamic observation and clinical significance of integrated traditional Chinese and Western medicine on interleukin-2 system, T cell and erythrocyte immune system in patients of lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20(8):586-8.

95

95 Qin ZF, Wei PK, Li J. Effect of kanglaite injection combined with Chinese drug therapy according to syndrome differentiation on quality of life and immune function in patients with advanced lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002;22(8):618-9.

96

96 Li LN, Liu WS, Xu K. Effect of combination of syndrome differentiation depending treatment and chemotherapy on prognostic factors in treating mid-late patients with non-small call lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003;23(8):575-9.

97

97 Zou YH, Liu XM. Effect of astragalus injection combined with chemotherapy on quality of life in patients with advanced non-small cell lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003;23(10):733-5.

98

98 Mori K, Kondo T, Kamiyama Y, Kano Y, Tominaga K. Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecaninduced diarrhea in advanced non-small-cell lung cancer. Cancer Chemother Pharmacol. 2003 May;51(5):403-6.

99

99 Lan X, Jiang Y. The therapeutic effects of the radiotherapy plus TCM treatment observed in senile non-parvicellular lung cancer patients at the late stage. J Tradit Chin Med. 2003;23(1): 32-4.

100

100 Bai CQ, Ni DT, Li NX, Liu GJ, Dong BR. Cost analysis of Shenqi Fuzheng injection on reducing adverse effects during chemotherapy. Zhonghua Liu Xing Bing Xue Za Zhi. 2003;24(2):130-4.

101

101 Fang WM, Wang WP, Yan BW, Zhou JY. Treatment of non-small-cell lung cancer with chemotherapy and Sansheng Huatan Decoction. Zhong Xi Yi Jie He Xue Bao. 2004;2(2):103-5.

102

102 Wang XM, Xin H, Yang Z, Zhao W, Yang G, Liu J, et al. Clinical study on treatment of advanced stage non-small cell lung cancer by guben xiaoliu capsule. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004;24(11):986-8.

103

103 Zhou DH, Lin LZ, Zhou YQ, Luo RC, Liu KF, Jia YJ, et al. Prognostic analysis of stage III-IV non-small cell lung cancer patients treated by traditional chinese medicine. Ai Zheng. 2005; 24(10):1252-6.

104

104 Shi J, Wei SJ, Shan BE. Clinical observation on treatment of cancerous hydrothorax by aiyishu injection. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;25(5):451-3.

105

105 Zhou DH, Lin LZ, Zhou YQ. Analysis of short-term therapeutic efficacy of integrated traditional and Western medicine in treating non-small cell lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;25(12):1061-5.

106

106 You J, Shi ZM, Han BH. Evaluation on effect of feiji recipe on quality of life of patients with non-small cell lung cancer by adopting international questionnaire of QOL. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26(1):33-7.

107

107 Lin LZ, Zhou DH, Zheng XT. Effect of traditional Chinese medicine in improving quality of life of patients with non-small cell lung cancer in late stage. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26(5):389-93.

108

108 Chen XP, Zhang YP, Zhu XR. Clinical study on effects of tiepi fengdou granule/capsule combined with chemotherapy and/or radiotherapy in treating lung cancer with Qi-Yin asthenia syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006; 26(5):394-7.

109

109 Cao Y, Li P, Tan KJ. Clinical observation on shenmai injection in preventing and treating adverse reaction of chemotherapy on advanced non-small cell lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26(6):550-2.

110

110 Pan YL, Pan YZ. Observation on the effect of zhiling capsule in treating patients with lung cancer of middle/advanced stage. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26(7):604-7.

111

111 Wu WY, Long SQ, Zhang HB, Chai XS, Deng H, Xue XG, et al. Improvement of quality of life with Shenfu injection in non small cell lung cancer patients treated with gemcitabine plus cisplatin regimen. Chin J Integr Med. 2006;12 (1):50-4.

112

112 Tian HQ, Yu SY, Wang B. Effect of Fructus Bruceae oil emulsion on cellular immune function and quality of life in patients with non-small cell lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(2):157-9.

113

113 Zhang T, Ma SL, Yue JH. Clinical study on toxicity-attenuation effect of Yiguan Decoction in treatment of non-small cell lung cancer with NP protocol of chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(5):396-9.

114

114 Huang YS, Shi ZM. Intervention effect of Feiji Recipe on immune escape of lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27 (6):501-4.

115

115 Xu ZY, Jin CJ, Shen DY. Clinical study on treatment of advanced non-small-cell lung cancer with Chinese herbal medicine in different stages combined with chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(10):874-8.

116

116 Zhang T. Effect of TCM therapy for removing toxic substance and unblocking meridians on post-radiation quality of life in 55 patients with lung cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008;28(2):154-7.

117

117 Adachi I, Watanabe T. Role of supporting therapy of Juzentaiho-to (JTT) in advanced breast cancer patients. Gan To Kagaku Ryoho. 1989;16(4):1538-43.

118

118 Liu P, Cao Y, Qiao X. Clinical study on shenmai injection in promoting postoperative recovery in patients of breast cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20(5):328-9.

119

119 Uglyanitsa KN, Nefyodov LI, Brzosko V. Comparative evaluation of the efficiency of various Ukrain doses in the combined treatment of breast cancer. Report 1. Clinical aspects of Ukrain application. Drugs Exp Clin Res. 2000;26 (5-6):223-30.

120

120 Heggie S, Bryant GP, Tripcony L, Keller J, Rose P, Glendenning M, Heath J. A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs. 2002;25(6): 442-51.

121

121 Liu F, Liu SH, Ren ZG. Clinical observation on treatment of multiple bone metastatic tumor of mammary cancer by combination therapy of 89Sr and Chinese herbal medicine. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003;23(4):265-7.

122

122 Zhao JX, Lian P, Li YT. Effect of fuzheng yiliu granule on nuclear transcriptional factor-kappa B and cell cycle in patients with breast carcinoma. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003; 23(6):421-2.

123

123 Hernandez Munoz G, Pluchino S. Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer. Maturitas. 2003; 44(Suppl 1):S59-65.

124

124 Semiglasov VF, Stepula VV, Dudov A, Lehmacher W, Mengs U. The standardised mistletoe extract PS76A2 improves QoL in patients with breast cancer receiving adjuvant CMF chemotherapy: a randomised, placebo-controlled, double-blind, multicentre clinical trial. Anticancer Res. 2004; 24(2C):1293-302.

125

125 Cluzan RV, Pecking AP, Mathiex-Fortunet H, Léger Picherit E. Efficacy of BN165 (Ginkor Fort) in breast cancer related upper limb lymphedema: a preliminary study. Lymphology. 2004;37(2):47-52.

126

126 Zhang QY, Zhao WH, Lai YJ. Effect on latestage mammary cancer treated by endocrinotherapy or chemotherapy combined with pingxiao capsule. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005; 25(12):1074-6.

127

127 Pockaj BA, Gallagher JG, Loprinzi CL, Stella PJ, Barton DL, Sloan JA, et al. Phase III doubleblind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1. J Clin Oncol. 2006;24(18):2836-41.

128

128 Semiglazov VF, Stepula VV, Dudov A, Schnitker J, Mengs U. Quality of life is improved in breast cancer patients by Standardised Mistletoe Extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial. Anticancer Res. 2006;26(2B):1519-29.

129

129 Liu S, Hua YQ, Sun ZP, Tan S, Lu DM. Clinical observation of Ruyiping in preventing recidivation and metastasis of breast cancer. Zhong Xi Yi Jie He Xue Bao. 2007;5(2):147-9.

130

130 Mok TS, Yeo W, Johnson PJ, Hui P, Ho WM, Lam KC, et al. A double-blind placebocontrolled randomized study of Chinese herbal medicine as complementary therapy for reduction of chemotherapy-induced toxicity. Ann Oncol. 2007;18(4):768-74.

131

131 Dyer J, Ashley S, Shaw C. A study to look at the effects of a hydrolat spray on hot flushes in women being treated for breast cancer. Complement Ther Clin Pract. 2008;14(4):273-9.

132

132 Yi SY, Nan KJ, Chen SJ, et al. Effect of extract of Ginkgo biloba on doxorubicin-associated cardiotoxicity in patients with breast cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008; 28(1):68-70.

133

133 Huang ZF, Wei JS, Li HZ, et al. Effect of Shenqi Fuzheng injection combined with chemotherapy on thirty patients with advanced breast cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008;28 (2):152-4.

134

134 Dai Z, Wan X, Kang H, Ji Z, Liu L, Liu X, et al. Clinical effects of shenqi fuzheng injection in the neoadjuvant chemotherapy for local advanced breast cancer and the effects on T-lymphocyte subsets. J Tradit Chin Med. 2008; 28(1):34-8.

135

135 Zhou A, Din Y, Chen M. Curative effects of modified xiao-jin pills and chemotherapy after surgery in patients with mid and late phase gastric cancer. Zhong Xi Yi Jie He Za Zhi.1990;10(6):343-4, 324.

136

136 Yu QS, Zhang FZ, Tang XR. Clinical study on early use of Chinese medicinal herbs and chemotherapy after operation of gastric cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995;15 (8):459-61.

137

137 Lin SY, Liu LM, Wu LC. Effects of Shenmai injection on immune function in stomach cancer patients after chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995;15(8):451-3.

138

138 Zhou AG, Huang DW, Ding YX. Clinical and experimental studies on treatment postoperative gastric cancer with combined therapy of fuzhen huoxue anticancer prescription and chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996;16 (9):519-21.

139

139 Ping B. The effects of Chinese drugs for supporting healthy energy and removing blood stasis on postoperative metastasis of gastric carcinoma and ornithine decarboxylase. J Tradit Chin Med. 1998;18(1):3-6.

140

140 Zhou K, Wang J, Liu B. Clinical study on effect of shenqi fuzheng injection combined with chemotherapy in treating gastric cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999;19(1):11-3.

141

141 Hua B, Wang A. Clinical study on treatment of mid-late stage gastric carcinoma by composite xiansu capsule combined with chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999;1 9(8):470-2

142

142 Suh SO, Kroh M, Kim NR. Effects of Red Ginseng upon Postoperative Immunity and Survival in Patients with Stage III Gastric Cancer. The American J of Chinese Medicine. 2002;30(4):483-94.

143

143 Yang JK, Zhen J, Shen KP. Clinical study on post-operative metastasis prevention of progressive stage of gastric cancer by weichang'an. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003;23(8):580-2.

144

144 Cai J, Xuan ZR, Wei YP, Yang HB, Wang H. Effects of perioperative administration of Rhubarb on acute inflammatory response in patients with gastric cancer. Zhong Xi Yi Jie He Xue Bao. 2005;3(3):195-8.

145

145 Yu QS, Liu Y, Hou Y, Zhang F, Yi W, Wang X, et al. Effect of early intestinal dripping of jianpi tongli Chinese herbs on serum level IL-2, sIL-2R and IL-12 in patients with gastric cancer after operation. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;25(8):710-3.

146

146 Zhu JS, Song MQ, Wang L, Sun Q, Zhu L, Fang C. Immunoregulation and short-term therapeutic effects of super-selective intra-arterial chemotherapy combined with traditional Chinese drugs on gastric cancer patients. Zhong Xi Yi Jie He Xue Bao. 2006;4(5):478-81.

147

147 Endo S, Nishida T, Nishikawa K, Nakajima K, Hasegawa J, Kitagawa T, et al. Dai-kenchu-to, a Chinese herbal medicine, improves stasis of patients with total gastrectomy and jejunal pouch interposition. Am J Surg. 2006;192(1):9-13.

148

148 Zhao JM, Wu AZ, Shi LR. Clinical observation on treatment of advanced gastric cancer by combined use of Shenqi Fuzheng injection, docetaxel, flurouracil and calcium folinate. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;2 (8):736-8.

149

149 Wang HZ, Wang HB, Gao H. Clinical observation on treatment of 34 advanced gastric carcinoma patients by chemotherapy of DCF regimen combined with Fuzheng Hewei Decoction. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27 (10):927-9.

150

150 Wang H, Guo LJ, Wu B, et al. Effect of rhubarb combined with enteral nutrition on C-reactive protein and interleukin-6 in peripheral blood of patients with gastric cancer during perioperative period. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008;28(2):101-4.

151

151 Xu GZ, Cai WM, Qin DX, Yan JH, Wu XL, Zhang HX, et al. Chinese herb "destagnation" series I: Combination of radiation with destagnation in the treatment of nasopharyngeal carcinoma (NPC): a prospective randomized trial on 188 cases. Int J Radiat Oncol Biol Phys. 1989;16(2): 297-300.

152

152 Han JQ, Chen YT, Man YY. Clinical study on effect of combined treatment of fuchunpian with radiotherapy on nasopharyngeal carcinoma. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995;15 (12):710-2.

153

153 Wang Q, Liu H, Qiao N. Effects of traditional Chinese medicine on salivary glands in the patients with head and neck cancer during radiotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998;18(11):662-4.

154

154 Wang B, Liu X, Wang T. Study of prevention and treatment on acute radioactive injury with huoxue yiqi yangyin recipe. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20(3):180-2.

155

155 Zhu X, Wang A, Wang S. Clinical study on effect of combined treatment with shenlong oral liquid and radiotherapy in treating nasopharyngeal carcinoma. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20(11):818-20.

156

156 Xie FY, Zeng ZF, Huang HY. Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(5):332-4.

157

157 Steuer-Vogt MK, Bonkowsky V, Ambrosch P, Scholz M, Neiss A, Strutz J, et al. The effect of an adjuvant mistletoe treatment programme in resected head and neck cancer patients: a randomised controlled clinical trial. Eur J Cancer. 2001;37(1):23-31.

158

158 Huang GX, Zhao C, Han F, Zhang B, Qiu HJ, Xu BP, et al. Clinical study in prophylactic use of chinese medicine to prevent chemoradiotherapy induced mucositis in nasopharyngeal carcinoma. Ai Zheng. 2003;22(10):1084-7.

159

159 Xu BP, Long SX, Hu WH. Study on prevention and treatment of radiotherapy caused post-visual pathway injury in nasopharyngeal carcinoma patients by traditional Chinese medicine. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003;23 (9):661-3.

160

160 Ravikumar L, Shah R, Pinto H, Halpern J, Koong A, Goffinet D, et al. Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasm. Int J Radiat Oncol Biol Phys. 2004;60(1):171-7.

161

161 Hu YR, Wu CQ, Liu YJ, Wang Y, Li X, Zhong H, et al. Clinical observation on effect of shenqi fanghou recipe in preventing and treating radiation injury in patients with head and neck tumor. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;25(7):623-5.

162

162 Zheng JX, Zhou TC, Xu K, Li LN. Effect of Selaginella combined with radiotherapy on nasopharyngeal carcinoma. Nan Fang Yi Ke Da Xue Xue Bao. 2006;26(2):247-8.

163

163 Bao YX, Wong CK, Leung SF, Chan AT, Li PW, Wong EL, et al. Clinical studies of immunomodulatory activities of Yunzhi-Danshen in patients with nasopharyngeal carcinoma. J Altern Complement Med. 2006;12(8):771-6.

164

164 Song PR, Qiu BS, Wu YT. Clinical observation on TCM treatment according to syndrome differentiation in relieving acute radio-reaction in nasopharyngeal carcinoma patients. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(5):452-5.

165

165 Li QS, Cao SH, Xie GM, Gan YH, Ma HJ, Lu JZ, et al. Combined traditional Chinese medicine and Western medicine. Relieving effects of Chinese herbs, ear-acupuncture and epidural morphine on postoperative pain in liver cancer. Chinese medical journal. 1994;107(4):289-94.

166

166 Oka H, Yamamoto S, Kuroki T, Harihara S, Marumo T, Kim SR, et al. Prospective study of chemoprevention of hepatocellular carcinoma with Sho-saiko-to (TJ-9). Cancer. 1995;76(5): 743-9.

167

167 Han JQ, Chen SD, Zhai LM. Clinical study of combined Chinese herbal medicine with move stripe field radiation in treating primary hepatocellular carcinoma. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997;17(8):465-6.

168

168 Zheng C, Feng G, Liang H. Bletilla striata as a vascular embolizing agent in interventional treatment of primary hepatic carcinoma. Chin Med J (Engl). 1998;111(12):1060-3.

169

169 Xu K, Li Z, Zhu D. The effect of gan fu le in interventional treatment of hepatocarcinoma. J.Trad Chinese Med. 2000;20(3):185-6

170

170 Shao ZX, Cheng ZG, Yin X. Clinical study on treatment of middle-advanced stage liver cancer by combined treatment of hepatic artery chemoembolization with gan'ai no. I and no. II. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 ;21(3):168-70.

171

171 Xu BP, Zhang YQ, Li SP. Effect of relieving blood stasis, strengthening spleen and soothing liver therapy in improving hepatic function in patients after liver-carcinomectomy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(10):742-3.

172

172 Chen Z, Zhai XF, Su YH, Wan XY, Li J, Xie JM, et al. Clinical observation of cinobufacini injection used to treat moderate and advanced primary liver cancer. Zhong Xi Yi Jie He Xue Bao. 2003;1(3):184-6.

173

173 Lin LZ, Zhou DH, Liu K, Wang FJ, Lan SQ, Ye XW. Analysis on the prognostic factors in patients with large hepatocarcinoma treated by shentao ruangan pill and hydroxycamptothecine. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;2 5(1):8-11.

174

174 Wu D, Bao WG, Ding YH. Clinical and experimental study of xiaoshui decoction in the treatment of primary liver cancer caused ascites. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;25 (12):1066-9.

175

175 Lin JJ, Jin CN, Zheng ML, Ouyang XN, Zeng JX, Dai XH. Clinical study on treatment of primary hepatocellular carcinoma by Shenqi mixture combined with microwave coagulation. Chin J Integr Med. 2005;11(2):104-10.

176

176 Guan CN, Cai LZ, Yue LQ, Zhang Y. Clinicel study on treatment of advanced primary liver cancer by Yanshu injection combining with chemotherapy. Zhongguo Zhong Yao Za Zhi. 2006;31(6):510-2.

177

177 Feng YL, Ling CQ, Chen Z, Li B, Gu W. Ginsenosides and dexamethasone in managing the liver injury and renal function after transcatheter arterial chemoembolization for hepatic carcinoma patient. Zhonghua Zhong Liu Za Zhi. 2006;28 (11):844-7.

178

178 Susak YM, Zemskov VS, Yaremchuk OY, Kravchenco OB, Yatsyk IM, Korsh OB. Comparison of chemotherapy and X-ray therapy with Ukrain monotherapy for colorectal cancer. Drugs Exp Clin Res. 1996;22(3-5):115-22.

179

179 Bondar GV, Borota AV, Yakovets YI, Zolotukhin SE. Comparative evaluation of the complex treatment of rectal cancer patients (chemotherapy and X-ray therapy, Ukrain monotherapy). Drugs Exp Clin Res. 1998;24(5-6):221-6.

180

180 Guo Z. Clinical observation on treatment of 38 cases of postoperational large intestinal cancer by fuzheng yiai decoction combined with chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999; 19(1):20-2.

181

181 Li H, Li H, Tang Z. Effect of chang'ai kangfu decoction on immunity in postoperational patients with large intestine cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20(8):580-2.

182

182 Xing JH, Chen YQ, Ji MX. Clinical study on effect of ginsenoside in inducing rectal cancer cell apoptosis. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(4):260-1.

183

183 Meng ZQ, Xu YY, Liu LM, Song MZ, Huang WX. Clinical evaluation of integration of transcatheter arterial chemoembolization and traditional Chinese medicine in treating metastatic liver cancer. Zhong Xi Yi Jie He Xue Bao. 2003;1(3):187-8, 233.

184

184 Liu J, Wang WP, Zhou YY. Observation on therapeutic effect of jianpi huoxue herbs combined with chemotherapy in treating postoperational colonic cancer patients. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;25(3):207-9.

185

185 Yang YF, Xu Y, Wu Y. Clinical randomized double-blinded controlled study on Quxie Capsule in reducing post-operational relapse and metastasis of colorectal cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(10):879-82.

186

186 Li HJ, Dong L, Fu SY. Comparative study on treatment of advanced colorectal cancer by Aidi injection combined with FOLFOX4 regimen and by FOLFOX4 regimen alone. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(12):1086-9.

187

187 Yang YF, Chen ZX, Xu Y, et al. Randomized controlled study on effect of Quxie capsule on the median survival time and qualify of life in patients with advanced colorectal carcinoma. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008; 28(2):111-4.

188

188 Yan Y. Analysis of therapeutical effectiveness in 35 cases of acute leukemia with therapy of Chinese integrated medicine. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995;15(11):643-5.

189

189 Guo XM, Li JX, Yang XF. Clinical observation on 112 cases with non-Hodgkin's lymphoma treated by Chinese herbs combined with chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997;17(6):325-7.

상단으로 이동

Journal of Korean Medicine