- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Glycemic Control Effects of Sanyak (Dioscoreae rhizoma) extract in Prediabetic Stage Patients.
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2010, v.31 no.5, pp.146-166
&
(2010). Glycemic Control Effects of Sanyak (Dioscoreae rhizoma) extract in Prediabetic Stage Patients.. Journal of Korean Medicine, 31(5), 146-166.
- Downloaded
- Viewed
Abstract
Objective: Few data were available on glycemic control at the early prediabetic stage, though it is the important stage to prevent diabetes mellitus. The purpose of this research was to examine the glycemic control effects of herb medicine treatment (DA-9802) in prediabetic stage patients Methods: In this randomized, single blind, placebo-controlled study, we compared Sanyak extract (DA-9802) with placebo for the treatment of glycemic control effects in prediabetic stage patients. 45 volunteers who satisfied the requirements were enrolled in the study. They took Sanyak extract (DA-9802) or placebo treatment three times a day for 8 weeks. Blood sugar, Total Symptom Score (TSS) and blood serum were measured at weeks 0, 4, and 8. Results: In the DA-9802 group, fasting blood sugar changes between before 8 weeks significantly decreased. Fasting blood sugar, fasting blood sugar gaps between before and after treatment for 8 weeks, insulin changes and C-peptide significantly decreased at 8 weeks compared with those of the placebo group. Conclusion: Herb medicine treatment (DA-9802) is effective in glycemic control on prediabetic stage.
- keywords
- Herb medicine treatment, prediabetic stage, fasting blood sugar, Total Symptom Score, C-peptide, Herb medicine treatment, prediabetic stage, fasting blood sugar, Total Symptom Score, C-peptide
Reference
1
1 Harrison TR. Principles of Internal Medicine, Diabetes Mellitus. 11th ed. New York: Mc- Graw-Hill Book Company. 1987:1778-1797.
2
2 Kannel WB, Megee DL. Diabetes and cardiovascular disease. JAHA 1979;241:2035-2038.
3
3 Abrams JJ, Ginsberg H, Grundy SM. Metabolism of cholesterol and plasma triglycerides in nonketotic diabetes mellitus. Diabetes 1982;31:903-910.
4
4 Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 1996;97:2601-2610.
5
5 Hayden JM, Reaven PD. Cardiovascular disease in diabetes mellitus type 2: a potential role for novel cardiovascular risk factors. Curr Opin Lipidol 2000;11:519-528.
6
6 Treadway JL, Mendys P, Hoover DJ. Glycogen phosphorylase inhibitors for the treatment of type 2 diabetes mellitus. Expert Opin Investig Drugs 2001;10:439-454.
7
7 Oscar H. Franco, Ewout W. Steyerberg, Frank B. Hu, Johan Mackenbach, Wilma Nusselder. Associations of Diabetes Mellitus With Total Life Expectancy and Life Expectancy With and Without Cardiovascular Disease. Archives of Internal Medicine. 2007;167:1145-1151.
8
8 박석원, 김대중, 민경완, 백세현, 최경묵, 박이병, 외. 전국표본조사에 의한 우리나라 당뇨병 관리실태: 건강보험자료 분석결과. 당뇨병, 2007;31(4):362-367.
9
9 Lee KW, Shon BH, Kang SK. Epidemiogical study for diabetes in 1821 koreans. Diabetes. 1984;8:5-14.
10
10 Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH, et al. Epidemic obesity and type 2 diabetes in Asia. Lancet. 2006 Nov 11;368 (9548):1681-8.
11
11 Vetrichelvan T,Jegadeesan M. Anti-diabetic activity of alcoholic extract of Aerva lanata(L.) Juss. ex Schultes in rats. J Ethnopharm. 2002; 80:103-7.
12
12 당뇨병학회. 당뇨병 교육자가 알아야 할 건강기능식품에 관한 것들, 임상당뇨병, 2006;7(1):63-69.
13
13 方藥中. 實用中醫內科學. 上海: 上海科學技術出版社. 1986:477.
14
14 문석재. 천화분 Extract의 가토 혈당 농도에 미치는 영향에 관한 연구. 동서의학. 1982;7(1):38-45.
15
15 김진택. 황백, 황련이 실험적 당뇨흰쥐에 미치는 영향. 방제학회지. 1990;1(1):163-72.
16
16 진철, 김미려, 양재하, 최종백. 고삼이 당뇨에 미치는 영향에 관한 실험적 연구. 동서의학.1991;16(3):47-67.
17
17 조웅행, 김윤상. 숙지황이 고과당 사료를 식이한 쥐의 혈액상에 미치는 영향. 대한본초학회지. 2003;18(1)73-8.
18
18 최해윤, 정태영, 서부일, 김종대, 박동일. Streptozotocin으로 유발된 당뇨 흰쥐에서 수종의 한약재가 혈당강하에 미치는 영향. 대한본초학회지.2003;18(2):121-27.
19
19 Kim JS. Effect of Rhemanniae Radix on the Hyperglycemic Mice Induced with Streptozotocin. J Korean Soc Food Sci Nutr. 2004;33(7):1133-8.
20
20 변성희. 육미지황탕 및 녹용가미방이 흰쥐 당뇨에 대한 면역조직화학적연구. 제한동의학술원논문집. 1995;1(1):1-16.
21
21 Lee YG, Kim SD. The Antidiabetic Effect of Gamiyookmijihwangtang on Diabetes - pron BB Rats. J Korean Soc Food Sci Nutr. 2000; 32(5):1206-12.
22
22 박선동, 주왕석, 고원도. 혈부축어탕과 그 구성 약물군이 Alloxan 당뇨병흰쥐의 혈청 조성 및 항산화 효과에 미치는 영향. 대한본초학회지. 2002;17(1):93-111.
23
23 Zhao G, Kan J, Z Li Z, Chen Z. Structural features and immunological activity of a polysaccharide from Dioscorea opposita Thunb roots. Sarbohyd. Plymers. 2005;61;125-131.
24
24 Kim MJ, Kim HN, Kang KS, Baek NI, Kim DK, Kim YS, et al. Methano extract of Dioscoreae rhizoma inhibits pro-inflammatory cytokines and mediators in the synoviocytes of rheumatoid arthritis. Int. Immunopharmacol. 2004;4:1489-97.
25
25 Yin J, Tezuka Y, Kouda K, Tran QL, Miyahara T, Chen Y, et al. Antiosteoprotic activity of the water extract of Dioscorea spongiosa. Biol. Pharm. Bull. 2004;27:583-589.
26
26 McAnuff MA, Harding WW, Omoruyi FO, Jacobs H, Morrison EY, Asemota HN. Hypoglycemic effects of steroidal sapogenins isolated from jamaican bitter yam, Dioscorea poygonoides. Food Chem. Toxicol. 2005;43:1667-1672.
27
27 Kwon CS, Sohn HY, Kim SH, Kim JH, Son KH, Lee JS, Lim JK, Kim JS. Anti-obesity effect of Dioscorea nipponica Makino with lipasseinhibitory activity in rodents. Biosci. Biotechnol.Biochem 2003;67:1451-1456.
28
28 신민교. 임상본초학, 서울, 영림사. 2000;185.
29
29 원도희 외. 약용식물도감. 서울. 식품의약품안전본부. 1997:16.
30
30 DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM; A balanced overview. Diabetes Care. 1992;15:318-353.
31
31 Kadowatki T, Yamauchi T, Terauchi Y, Tobe K. Nagai R,. Molecular mechanism of insulin resistance and obesity. Exp. Biol. Med. 2003; 228:1111-1117.
32
32 Min HK. Clincal chracteristics of Korean diabetic patients. Kor. J. Diabetes. 1992;16:163-170.
33
33 Kim J, Choi S, Kong B, Oh Y, Shin S. Insulin secretion and sensitivity during oral glucose tolerance test in Korean lean elderly women. J. Korean MEd. Sci. 2001;16:592-596.
34
34 박상갑, 정종훈, 조재기, 하영주, 김종인, 박현태.지구성운동이 제2형 당뇨병환자의 당질 및 인슐린 대사에 미치는 영향. 대한스포츠의학회지. 1997;15:427-431.
35
35 Fineman MS, Bicsak TA, Shen LZ, Taylor K, Gaines E, Varns A, et al. D. Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and sulfonylurea treatment in patients with type 2 diabetes. Diabetes Care. 2003;26:2370-2377.
36
36 Tosi F, Muggeo M, Coppini A, Moghetti P. Combination treatment with metformin and glibenclamide versus single-drug therapies in type 2 diabetes mellitus: a randomized, doubleblind, comparative study. metabolism. 2003;52: 862-867.
37
37 Oudjerioat N, Moreau Y, Santimone M, Svensson B, Marchis-Mouren G, Desseux V. On the mechanism of alpha-amylase. Eur. J. Biochem. 2003;270:3871-3879.
38
38 대한당뇨학회. 당뇨병학. 서울, 고려의학. 2005:173-5.
39
39 http://www.diabetes.or.kr/notice/list.php?code=broad.
40
40 Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, et al. Quantif ication of the relationship between insulin sensitivity and beta- cell f unction in human subj ects: evidence f or a hyp erbolic f unction. Diabetes 1993;42:1663-1672.
41
41 Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of g lucose and insulin resistance in development of typ e 2 diabetes mellitus: results of a 25- year followup study. Lancet 1992;340:925-929.
42
42 채봉남, 이성규, 홍은경, 김윤정, 노혜림, 정윤석외. 한국인 제2형 당뇨병의 병인에서 인슐린 분비능과 저항성의 역할. 당뇨병 1998;22:491-503.
43
43 Vaag A, Henriksen JE, Madsbad S, Holm N, Beck-Nielsen H. Insulin secretion, insulin action, and hepatic glucose p roduction in identical twins discordant f or non- insulin- dep endent diabetes mellitus. J Clin Invest 1995;95:690-698.
44
44 김효정. 12주간의 운동 프로그램 시행에 의한 제2형 당뇨병 고위험군의 대사개선 효과. 한국사회체육학회지. 2003;20:1079-1089.
45
45 서교일. 인슐린저항성의 발생기전: 체내 지방질대사 이상이 포도당대사에 미치는 영향. 과학기술부 연구보고서. 2000:3-4.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- A Systematic Review fromthe Journals under theKorean Oriental Medical Society
- Review of Randomized Controlled Trials using Herbal Remedies on Cancer Patients
- Reviewing the Education of Oriental Medicine in Uzbekistan: with Reference to the Data in a Medical Academy
- Study about Oriental Medical Diagnosis and Approach Related to Weighting According to Differentiation of Chronic Tension-type Headaches
- Consideration of the Fundamental Principles of IPL and Clinical Applications for Korean Medicine
- Suppressive Effects of Yijintang-gamibang on Reflux Esophagitis
- TOAST Distribution of Ischemic Stroke Patients Admitted to Oriental Hospitals
- The Hepatoprotective Activity of Spatholobi Caulis Water Extract against Cadmium-Induced Toxicity in Rats
- Design and Implementation of Paper Map for Traditional Korean Medicine
- Stimulation of the Immune Response by Yin-Tonifying Formula
- Effects of Concurrent Administration of Sopunghwalhyeol-tang and Clopidogrel on Atherosclerosis in the ApoE(-/-) Mouse
- A Study on Using EAV (MERIDIAN) by Analysis of Cerebrovascular Disease Risk Factors
- Glycemic Control Effects of Sanyak (Dioscoreae rhizoma) extract in Prediabetic Stage Patients.
- The Neuroprotective Effect of Acupuncture Treatment at Shaofu (HT8) on Kainic Acid-induced Epilepsy Mouse Model.
- A Case of Erythrodermic Psoriasis
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.