1. 전국한의과대학 공동교재편찬위원회 공저. 본초 학. 서울:영림사. 2004:629-31.

2. 황도연. 남산당 편집국 역. 證脈․方藥合編. 서 울:남산당. 2004:147.

3. 주영승. 耘谷 本草學: 總論. 서울:서림재. 2002: 377,391.

4. 주영승. 耘谷 本草學: 各論 下. 서울:서림재. 2002:448.

5. Kim JY, Yoon YD, Ahn JM, Kang JS, Park SK, Lee K, et al. Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4. Int Immunopharmacol. 2007;7:78-87.

6. Yim D, Singh RP, Agarwal C, Lee S, Chi H, Agarwal R. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. 2005; 65:1035-44.

7. Wan YQ, Liu YX, Guo L, Wan XF. Determin ation of trace elements in danggui bloodsupplementing decoction by ICP-AES. Mol Cancer Ther. 2007;27:160-4.

8. Kim MR, Abd El-Aty AM, Choi JH, Lee KB, Shim JH. Identification of volatile components in Angelica species using supercritical-CO2 fluid extraction and solid phase microextraction coupled to gas chromatography-mass spectrometry. Biomed Chromatogr. 2006;20:1267-73.

9. Kim MR, El-Aty AMA, Kim IS, Shim JH. Determination of volatile flavor components in danggui cultivar by solvent free injection and hydrodistillation followed by gas chromatographicmass spectrometric analysis. J Chromatogr A. 2006;1116:259-64.

10. Mao X, Kong L, Luo Q, Li X, Zou H. Screening and analysis of permeable compounds in radix Angelica sinensis with immobilized liposome chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;779:331-9.

11. Wedge DE, Klun JA, Tabanca N, Demirci B, Ozek T, Baser KH, et al. Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity. J Agric Food Chem. 2009;57:464-70.

12. Kan WL, Cho CH, Rudd JA, Lin G. Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells. J Ethnopharmacol. 2008;120:36-43.

13. Li SY, Yu Y, Li SP. Identification of antioxidants in essential oil of Radix Angelicae sinensis using HPLC coupled with DAD-MS and ABTS-based assay. J Agric Food Chem. 2007; 55:3358-62.

14. Du L, Wang X, Cai C, Wang T. Constituent analysis of essential oils from Radix of Angelica acutiloba. Zhong Yao Cai. 2002;25:477-8.

15. Lu GH, Chan K, Chan CL, Leung K, Jiang ZH, Zhao ZZ. Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by highperformance liquid chromatography and liquid chromatography-mass spectrometry. J Chromatogr A. 2004;1046:101-7.

16. Song GY, Lee JH, Cho M, Park BS, Kim DE, Oh S. Decursin suppresses human androgenindependent PC3 prostate cancer cell proliferation by promoting the degradation of betacatenin. Mol Pharmacol. 2007;72:1599-606.

17. Lee MY, Lim SH, Joo YS, Han KS, Jung KJ, Ahn DK, et al. Discrimination of the three Angelica species using the RAPDs and internal root structure. Korean J Medicainal Crop Sci. 2000;8(3):243-9.

18. Rhyu MR, Kim JH, Kim EY. Radix Angelica elicits both nitric oxide-dependent and calcium influx-mediated relaxation in rat aorta. J Cardiovasc Pharmacol. 2005;46:99-104.

19. Lam HW, Lin HC, Lao SC, Gao JL, Hong SJ, Leong CW, et al. The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo. Journal of Cellular Biochemistry. 2008;103:195-211.

20. Lee YY, Lee S, Jin JL, Yun-Choi HS. Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Arch Pharm Res. 2003;26:723-6.

21. Suzuki A, Kagawa D, Fujii A, Ochiai R, Tokimitsu I, Saito I. Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats. Am J Hypertens. 2002;15: 351-7.

22. Wang Z, Gao YH, Huang RS, Zhu GQ. Sodium ferulate is an inhibitor of thromboxane A2 synthetase. Zhongguo Yao Li Xue Bao. 1988; 9:430-3.

23. Wang XJ, Huang WZ, Zhang BY. Recent study on effect of Angelica sinensis on the balance between TXA2 and PGI2 in human. Hubei Zhongyi Zazhi. 2000;22:53-4.

24. Du JR, Yu Y, Yao Y, Bai B, Zong X, Lei Y, et al. Ligustilide reduces phenylephrine induced-aortic tension in vitro but has no effect on systolic pressure in spontaneously hypertensive rats. Am J Chin Med. 2007;35:487-96.

25. Kim HH. Lee JH, Lee JH, Ahn DK, Park SK. Vasodilation effect of the water extract of three Angelica species and four - substance decoctions in rat thoracic aorta. Korean J Herbology. 2001; 16:29-34.

26. Meng H, Guo J, Sun JY, Pei JM, Wang YM, Zhu MZ, et al. Angiogenic effects of the extracts from chinese herbs: Angelica and Chuanxiong. Am J Chin Med. 2008;36:541-54.

27. Meng H, Zhu MZ, Guo J, Sun JY, Pei JM, Huang C. The study on angiogenesis activity of danggui, chuanxiong and danshen. Zhong Yao Cai. 2006; 29:574-6.

28. Xin YF, Zhou GL, Shen M, Chen YX, Liu SP, Chen GC, et al. Angelica sinensis: A novel adjunct to prevent doxorubicin-induced chronic cardiotoxicity. Basic Clin Pharmacol Toxicol. 2007;101:421-6.

29. Zhang L, Du JR, Wang J, Yu DK, Chen YS, He Y, et al. Z-ligustilide extracted from Radix Angelica sinensis decreased platelet aggregation induced by ADP ex vivo and arterio-venous shunt thrombosis in vivo in rats. Yakugaku Zasshi. 2009;129:855-9.

30. Wang S, Gao Z, Chen X, Lian X, Zhu H, Zheng J, et al. The anticoagulant ability of ferulic acid and its applications for improving the blood compatibility of silk fibroin. Biomed Mater. 2008;3:44106.

31. Zhui Y, Jing-Ping OY, Yongming L, Lei W, Shuzheng T, Hailu Y, et al. Experimental study of the antiatherogenesis effect of chinese medicine Angelica and its mechanisms. Clin Hemorheol Microcirc. 2000;22:305-10.

32. Wang BH, Ouyang JP, Liu YM, Wei L, Yang JW. Protective effect of Angelica on ECV(304) from injury induced by hyperlipidemic serum in vitro. Sheng Li Xue Bao. 2001;53:240-3.

33. Kang SY, Kim YC. Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity. J Pharm Pharmacol. 2007;59:863-70.

34. Huang SH, Lin CM, Chiang BH. Protective effects of Angelica sinensis extract on amyloid (beta)-peptide-induced neurotoxicity. Phytomedicine. 2008;15:710-21.

35. Kang SY, Lee KY, Sung SH, Park MJ, Kim YC. Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships. J Nat Prod. 2001;64:683-5.

36. Kang SY, Kim YC. Neuroprotective coumarins from the root of Angelica gigas: structureactivity relationships. Arch Pharm Res. 2007;30: 1368-73.

37. Kang SY, Lee KY, Sung SH, Kim YC. Four new neuroprotective dihydropyranocoumarins from Angelica gigas. J Nat Prod. 2005;68:56-9.

38. Kang SY, Lee KY, Park MJ, Kim YC, Markelonis GJ, Oh TH. Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice. Neurobiol Learn Mem. 2003;79:11-8.

39. Jeon YI, Park CS, Park CG. An experimental study of effect on brain damage and neuroprotective effect of Angelicae gigantis radix extract against cerebral ischemia in rats. Korean J Herbology. 2003;18:25-35.

40. Kang HJ, Yoon TS, Jeong DG, Kim Y, Chung JW, Ha JS, et al. Identification of proteins binding to decursinol by chemical proteomics. J Microbiol Biotechnol. 2008;18:1427-30.

41. Kuang X, Yao Y, Du JR, Liu YX, Wang CY, Qian ZM. Neuroprotective role of z-ligustilide against forebrain ischemic injury in ICR mice. Brain Res. 2006;1102:145-53.

42. Yan JJ, Kim DH, Moon YS, Jung JS, Ahn EM, Baek NI, et al. Protection against beta-amyloid peptide-induced memory impairment with longterm administration of extract of Angelica gigas or decursinol in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:25-30.

43. Hsieh MT, Lin YT, Lin YH, Wu CR. Radix Angelica sinensis extracts ameliorate scopolamineand cycloheximide-induced amnesia, but not p-chloroamphetamine-induced amnesia in rats. Am J Chin Med. 2000;28:263-72.

44. Kuang X, Du JR, Liu YX, Zhang GY, Peng HY. Postischemic administration of z-ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. Pharmacol Biochem Behav. 2008;88: 213-21.

45. Hatip-Al-Khatib I, Egashira N, Mishima K, Iwasaki K, Kurauchi K, Inui K, et al. Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat’s spatial cognition in eight-armed radial maze test. J Pharmacol Sci. 2004;96:33-41.

46. Choi SS, Han KJ, Lee HK, Han EJ, Suh HW. Antinociceptive profiles of crude extract from roots of Angelica gigas Nakai in various pain models. Biol Pharm Bull. 2003;26:1283-8.

47. Zhao RJ, Koo BS, Kim GW, Jang EY, Lee JR, Kim MR, et al. The essential oil from Angelica gigas Nakai suppresses nicotine sensitization. Biol Pharm Bull. 2005;28:2323-6.

48. Matsumoto K, Kohno S, Ojima K, Tezuka Y, Kadota S, Watanabe H. Effects of methylenechloridesoluble fraction of Japanese angelica root extract, ligustilide and butylidenephthalide, on pentobarbital sleep in group-housed and socially isolated mice. Life Sci. 1998;62:2073-82.

49. Seo YJ, Kwon MS, Park SH, Sim YB, Choi SM, Huh GH, et al. The analgesic effect of decursinol. Arch Pharm Res. 2009;32:937-43.

50. Chang GT, Min SY, Kim JH, Kim SH, Kim JK, Kim CH. Anti-thrombic activity of Korean herbal medicine, Dae-Jo-Whan and its herbs. Vascul Pharmacol. 2005;43:283-8.

51. Chen SW, Min L, Li WJ, Kong WX, Li JF, Zhang YJ. The effects of Angelica essential oil in three murine tests of anxiety. Pharmacology Biochemistry and Behavior. 2004;79:377-82.

52. Deng S, Chen SN, Yao P, Nikolic D, van Breemen RB, Bolton JL, et al. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J Nat Prod. 2006;69:536-41.

53. Ahn KS, Sim WS, Lee IK, Seu YB, Kim IH. Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Planta Med. 1997;63:360-1.

54. Ahn KS, Sim WS, Kim IH. Decursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigas. Planta Med. 1996;62:7-9.

55. Guo J, Jiang C, Wang Z, Lee HJ, Hu H, Malewicz B, et al. A novel class of pyranocoumarin anti-androgen receptor signaling compounds. Mol Cancer Ther. 2007;6:907-17.

56. Tsai NM, Chen YL, Lee CC, Lin PC, Cheng YL, Chang WL, et al. The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo. J Neurochem. 2006;99: 1251-62.

57. Chen QC, Lee J, Jin W, Youn U, Kim H, Lee IS, et al. Cytotoxic constituents from Angelicae sinensis radix. Arch Pharm Res. 2007;30:565-9.

58. Zheng M, Wang YP. Experimental study on effect of Angelica polysaccharide in inhibitory proliferation and inducing differentiation of K562 cells. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002;22:54-7.

59. Jung MH, Lee SH, Ahn EM, Lee YM. Decursin and decursinol angelate inhibit VEGF-induced angiogenesis via suppression of the VEGFR-2- signaling pathway. Carcinogenesis. 2009;30: 655-61.

60. Son SH, Kim MJ, Chung WY, Son JA, Kim YS, Kim YC, et al. Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase. Cancer Lett. 2009; 280:86-92.

61. Kim HH, Sik Bang S, Seok Choi J, Han H, Kim IH. Involvement of PKC and ROS in the cytotoxic mechanism of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562 erythroleukemia and U937 myeloleukemia cells. Cancer Lett. 2005; 223:191-201.

62. Lee HJ, Lee EO, Lee JH, Lee KS, Kim KH, Kim SH, et al. In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin. Am J Chin Med. 2009;37:127-42.

63. Han SB, Lee CW, Kang MR, Yoon YD, Kang JS, Lee KH, et al. Pectic polysaccharide isolated from Angelica gigas Nakai inhibits melanoma cell metastasis and growth by directly preventing cell adhesion and activating host immune functions. Cancer Lett. 2006;243:264-73.

64. Cheng YL, Chang WL, Lee SC, Liu YG, Chen CJ, Lin SZ, et al. Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis. Life Sci. 2004;75:1579-94.

65. Lee WH, Jin JS, Tsai WC, Chen YT, Chang WL, Yao CW, et al. Biological inhibitory effects of the Chinese herb danggui on brain astrocytoma. Pathobiology. 2006;73:141-8.

66. Tsai NM, Lin SZ, Lee CC, Chen SP, Su HC, Chang WL, et al. The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo. Clin Cancer Res. 2005;11: 3475-84.

67. Chen YL, Jian MH, Lin CC, Kang JC, Chen SP, Lin PC, et al. The induction of orphan nuclear receptor Nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma cell therapy. Mol Pharmacol. 2008;74:1046-58.

68. Shang P, Qian AR, Yang TH, Jia M, Mei QB, Cho CH, et al. Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis. World J Gastroenterol. 2003;9:1963-7.

69. Cao W, Li XQ, Wang X, Li T, Chen X, Liu SB, et al. Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis(Oliv.) Diels. Int J Biol Macromol. 2010;46:115-22.

70. Cao W, Li XQ, Hou Y, Fan HT, Zhang XN, Mei QB. Structural analysis and anti-tumor activity in vivo of polysaccharide APS-2a from Angelica sinensis. Zhong Yao Cai. 2008;31:261-6.

71. Yang T, Jia M, Meng J, Wu H, Mei Q. Immunomodulatory activity of polysaccharide isolated from Angelica sinensis. Int J Biol Macromol. 2006;39:179-84.

72. Han SB, Kim YH, Lee CW, Park SM, Lee HY, Ahn KS, et al. Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai. Immunopharmacology. 1998;40:39-48.

73. Jeon YJ, Kim HM. Experimental evidences and signal transduction pathways involved in the activation of NF-(kappa)B/Rel by angelan in murine macrophages. Int Immunopharmacol. 2001;1:1331-9.

74. Young Jin J, Sang Bae H, Lee SH, Kim HC, Kyung Seop A, Hwan Mook K. Activation of mitogen-activated protein kinase pathways by angelan in murine macrophages. Int Immunopharmacol. 2001;1:237-45.

75. Jeon YJ, Han SB, Ahn KS, Kim HM. Activation of NF-(kappa)B/Rel in angelan-stimulated macrophages. Immunopharmacology. 1999;43:1-9.

76. Kim DH, Kim do Y, Kim YC, Jung JW, Lee S, Yoon BH, et al. Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Life Sci. 2007; 80:1944-50.

77. Kim HM, Kang JS, Park SK, Lee K, Kim JY, Kim YJ, et al. Antidiabetic activity of angelan isolated from Angelica gigas Nakai. Arch Pharm Res. 2008;31:1489-96.

78. Alleva LM, Cai C, Clark IA. Using complementary and alternative medicines to target the host response during severe influenza. Evid Based Complement Alternat Med. 2010;7: 501-10.

79. Wang H, Li W, Li J, Rendon-Mitchell B, Ochani M, Ashok M, et al. The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J Nutr. 2006;136:360-5.

80. Hui MK, Wu WK, Shin VY, So WH, Cho CH. Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice. Int J Med Sci. 2006;3:1-6.

81. Hatano R, Takano F, Fushiya S, Michimata M, Tanaka T, Kazama I, et al. Water-soluble extracts from Angelica acutiloba Kitagawa enhance hematopoiesis by activating immature erythroid cells in mice with 5-fluorouracil-induced anemia. Exp Hematol. 2004;32:918-24.

82. Song SH, Seo BI, Kim HK, Park JH. The effects of Angelicae gigantis radix, Angelicae acutilobae radix and Angelicae sinensis radix extract on hydrocortisone acetate-induced model of blood stasis. Korean J Herbology. 2004;19:13-21.

83. Shin S, Jeon JH, Park D, Jang JY, Joo SS, Hwang BY, et al. Anti-inflammatory effects of an ethanol extract of Angelica gigas in a carrageenan-air pouch inflammation model. Exp Anim. 2009;58:431-6.

84. Kim JH, Jeong JH, Jeon ST, Kim H, Ock J, Suk K, et al. Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-(kappa)B activation in macrophages. Mol Pharmacol. 2006;69:1783-90.

85. Ohshiro T, Namatame I, Lee EW, Kawagishi H, Tomoda H. Molecular target of decursins in the inhibition of lipid droplet accumulation in macrophages. Biol Pharm Bull. 2006;29:981-4.

86. Choi YE, Ahn H, Ryu JH. Polyacetylenes from Angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages. Biol Pharm Bull. 2000;23:884-6.

87. Chao WW, Kuo YH, Li WC, Lin BF. The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions. J Ethnopharmacol. 2009;122:68-75.

88. Chu Q, Hashimoto K, Satoh K, Wang Q, Sakagami H. Effect of three herbal extracts on NO and PGE2 production by activated mouse macrophage-like cells. In Vivo. 2009;23:537-44.

89. Li H, Wang Q. Evaluation of free hydroxyl radical scavenging activities of some Chinese herbs by capillary zone electrophoresis with amperometric detection. Anal Bioanal Chem. 2004;378:1801-5.

90. Jia M, Yang TH, Yao XJ, Meng J, Meng JR, Mei QB. Anti-oxidative effect of Angelica polysaccharide sulphate. Zhong Yao Cai. 2007; 30:185-8.

91. Yang X, Zhao Y, Wang Q, Wang H, Mei Q. Analysis of the monosaccharide components in Angelica polysaccharides by high performance liquid chromatography. Anal Sci. 2005;21:1177- 80.

92. Yang X, Zhao Y, Zhou Y, Lv Y, Mao J, Zhao P. Component and antioxidant properties of polysaccharide fractions isolated from Angelica sinensis(OLIV.) DIELS. Biol Pharm Bull. 2007;30:1884-90.

93. Yang X, Zhao Y, Lv Y, Yang Y, Ruan Y. Protective effect of polysaccharide fractions from Radix A. sinensis against tert-butylhydroperoxide induced oxidative injury in murine peritoneal macrophages. J Biochem Mol Biol. 2007;40:928- 35.

94. Yang X, Zhao Y, Wang H, Mei Q. Macrophage activation by an acidic polysaccharide isolated from Angelica sinensis(Oliv.) Diels. J Biochem Mol Biol. 2007;40:636-43.

95. Yu Y, Du JR, Wang CY, Qian ZM. Protection against hydrogen peroxide-induced injury by z-ligustilide in PC12 cells. Exp Brain Res. 2008; 184:307-12.

96. Dietz BM, Liu D, Hagos GK, Yao P, Schinkovitz A, Pro SM, et al. Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1. Chem Res Toxicol. 2008;21:1939-48.

97. Cho CH, Mei QB, Shang P, Lee SS, So HL, Guo X, et al. Study of the gasQB, intestinal protective effects of polysaccharides from Angelica sinensis in rats. Planta Med. 2000;66:348-51.

98. Ye YN, Liu ES, Shin VY, Koo MW, Li Y, Wei EQ, et al. A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line. Biochem Pharmacol. 2001; 61:1439-48.

99. Ye YN, Koo MW, Li Y, Matsui H, Cho CH. Angelica sinensis modulates migration and proliferation of gastric epithelial cells. Life Sci. 2001;68:961-8.

100. Wong VKC, Yu L, Cho CH. Protective effect of polysaccharides from Angelica sinensis on ulcerative colitis in rats. Immunopharmacology. 2008;16:162-7.

101. Liu SP, Dong WG, Wu DF, Luo HS, Yu JP. Protective effect of Angelica sinensis polysaccharide on experimental immunological colon injury in rats. World J Gastroenterol. 2003;9: 2786-90.

102. Han MJ, Bae EA. Bifidogenic effects of yaksun(functional herbal) food materials. Korean J Soc Food Cookery Sci. 2001;17:17-23.

103. Kim JD, Kim MY, Ahn CB, Seo HJ, Kim BJ, Seo JK, et al. The growth promotion effect of useful enterobacteria Bifidobacterium adolescentis KCTC 3216 by combination of natural products bearing antioxidative capacity. Korean J Biotechnol Bioeng. 2002;17:388-95.

104. Ye YN, Liu ES, Li Y, So HL, Cho CC, Sheng HP, et al. Protective effect of polysaccharidesenriched fraction from Angelica sinensis on hepatic injury. Life Sci. 2001;69:637-46.

105. Ding H, Peng R, Yu J. Modulation of Angelica sinensis polysaccharides on the expression of nitric oxide synthase and Bax, Bcl-2 in liver of immunological liver-injured mice. Zhonghua Gan Zang Bing Za Zhi. 2001;9:50-2.

106. Xia XY, Peng RX, Kong R, Yang ZQ, Chen X. Effects of Angelica sinensis polysaccharides on hepatic drug metabolism enzymes activities in mice. Zhongguo Zhong Yao Za Zhi. 2003;28: 149-52.

107. Zhao H, Alexeev A, Sharma V, Guzman LD, Bojanowski K. Effect of SBD.4A--a defined multicomponent preparation of Angelica sinensis-- in periodontal regeneration models. Phytother Res. 2008;22:923-8.

108. Zhao H, Mortezaei R, Wang Y, Sheng X, Aria F, Bojanowski K. SBD.4 stimulates regenerative processes in vitro, and wound healing in genetically diabetic mice and in human skin/ severe-combined immunodeficiency mouse chimera. Wound Repair Regen. 2006;14:593-601.

109. Yang Q, Populo SM, Zhang J, Yang G, Kodama H. Effect of Angelica sinensis on the proli feration of human bone cells. Clinica Chimica Acta. 2002;324:89-97.

110. Deng S, Wang Y, Inui T, Chen SN, Farnsworth NR, Cho S, et al. Anti-TB polyynes from the roots of Angelica sinensis. Phytother Res. 2008; 22:878-82.

111. Lee S, Shin DS, Kim JS, Oh KB, Kang SS. Antibacterial coumarins from Angelica gigas roots. Arch Pharm Res. 2003;26:449-52.

112. Shiomi K, Hatano H, Morimoto H, Ui H, Sakamoto K, Kita K, et al. Decursin and decursinol angelate selectively inhibit NADHfumarate reductase of Ascaris suum. Planta Med. 2007;73:1478-81.

113. Park MJ, Kang SJ, Kim AJ. Hypoglycemic effect of Angelica gigas Nakai extract in streptozotocininduced diabetic rats. Korean J Food & Nutr. 2009;22:246-51.

114. Guo AJ, Choi RC, Cheung AW, Li J, Chen IX, Dong TT, et al. Stimulation of Apolipoprotein A-IV expression in Caco-2/TC7 enterocytes and reduction of triglyceride formation in 3T3-L1 adipocytes by potential anti-obesity Chinese herbal medicines. Chin Med. 2009;4:5.

115. Circosta C, Pasquale RD, Palumbo DR, Samperi S, Occhiuto F. Estrogenic activity of standardized extract of Angelica sinensis. Phytother Res. 2006;20:665-9.

116. Han G, Zhou YF, Zhang MS, Cao Z, Xie CH, Zhou FX, et al. Angelica sinensis down-regulates hydroxyproline and Tgfb1 and provides protection in mice with radiation-induced pulmonary fibrosis. Radiat Res. 2006;165:546-52.

117. Xie CH, Zhang MS, Zhou YF, Han G, Cao Z, Zhou FX, et al. Chinese medicine Angelica sinensis suppresses radiation-induced expression of TNF-alpha and TGF-beta1 in mice. Oncol Rep. 2006;15:1429-36.

118. Xu J, Li G. Observation on short-term effects of Angelica injection on chronic obstructive pulmonary disease patients with pulmonary hypertension. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20:187-9.

119. Dong WG, Liu SP, Zhu HH, Luo HS, Yu JP. Abnormal function of platelets and role of Angelica sinensis in patients with ulcerative colitis. World J Gastroenterol. 2004;10:606-9.

120. Bradley RR, Cunniff PJ, Pereira BJ, Jaber BL. Hematopoietic effect of Radix Angelicae sinensis in a hemodialysis patient. Am J Kidney Dis. 1999;34:349-54.

121. Liu YM, Zhang JJ, Jiang J. Observation on clinical effect of Angelica injection in treating acute cerebral infarction. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004;24:205-8.

122. Wong AY, Chan KS, Lau WL, Tang LC. Pregnancy outcome of a patient with atypical polypoid adenomyoma. Fertil Steril. 2007;88: 1438e7-9.

123. Hirata JD, Swiersz LM, Zell B, Small R, Ettinger B. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebocontrolled trial. Fertil Steril. 1997;68:981-6.

124. Kim KM, Kim MJ, Kang JS. Absorption, distribution, metabolism, and excretion of decursin and decursinol angelate from Angelica gigas Nakai. J Microbiol Biotechnol. 2009;19: 1569-72.

125. Kim NJ, Seo SH, Lee KY, Park NJ. Comparative studies on concentration of decursinol in plasma after oral administration of Angelicae gigantis radix extract and combined use of decursin and Cnidii rhizoma extract or Bupleuri radix extract in rats. Kor J Pharmacogn. 2001;32:72-8.

126. Yoo HH, Lee MW, Kim YC, Yun CH, Kim DH. Mechanism-based inactivation of cytochrome P450 2A6 by decursinol angelate isolated from Angelica gigas. Drug Metab Dispos. 2007;35: 1759-65.

127. Hye HY, Min WL, Young CK, Yun CH, Kim DH. Mechanism-based inactivation of cytochrome P450 2A6 by decursinol angelate isolated from Angelica gigas. Drug Metabolism and Disposition. 2007;35:1759-65.

128. Abd El-Aty AM, Shah SS, Kim BM, Choi JH, Cho HJ, Hee Y, et al. In vitro inhibitory potential of decursin and decursinol angelate on the catalytic activity of cytochrome P-450 1A1/2, 2D15, and 3A12 isoforms in canine hepatic microsomes. Arch Pharm Res. 2008;31:1425-35.

129. Miles JS, McLaren AW, Forrester LM, Glancey MJ, Lang MA, Wolf CR. Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity. Biochem J. 1990;267:365-371.

130. Yun C, Shimada T, Guengerich FP. Purification and characterization of human liver microsomal cytochrome P-450 2A6. Mol Pharmacol. 1991; 40:679-685.

131. Pelkonen O, Mäenpää J, Taavitsainen P, Rautio, A, Raunio H. Inhibition and induction of human cytochrome P450(CYP) enzymes. Xenobiotica. 1998;28:1203-1253.

132. Yang XF, Wang NP, Zeng FD. Effects of the active components of some Chinese herbs on drug-metabolizing enzymes. Zhongguo Zhong Yao Za Zhi. 2002;27:325-328.

133. Kuroha M, Kuze Y, Shimoda M, Kokue E. In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes. Am. J. Vet. Res. 2002;63:900-905.

134. Krishna DR, Shekar MS. Cytochrome P450 3A: genetic polymorphisms and inter-ethnic differences. Methods Find. Exp. Clin. Pharmacol. 2005;27: 559-567.

135. Han SB, Lee CW, Kang MR, Yoon YD, Kang JS, Lee KH, et al. Pectic polysaccharide isolated from Angelica gigas Nakai inhibits melanoma cell metastasis and growth by directly preventing cell adhesion and activating host immune functions. Cancer Lett. 2006;243:264-73.

136. Yu YL, Yu SL, Su KJ, Wei CW, Jian MH, Lin PC, et al. Extended O(6)-methylguanine methyltransferase promoter hypermethylation following n-butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea(BCNU) on inhibition of human hepatocellular carcinoma cell growth. J Agric Food Chem. 2010;58: 1630-8.

137. Page RL, 2nd, Lawrence JD. Potentiation of warfarin by dong quai. Pharmacotherapy. 1999; 19:870-6.

138. Lo AC, Chan K, Yeung JH, Woo KS. Danggui (Angelica sinensis) affects the pharmacodynamics but not the pharmacokinetics of warfarin in rabbits. Eur J Drug Metab Pharmacokinet. 1995;20:55-60.

139. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause. 2002;9: 145-50.

140. Lau CB, Ho TC, Chan TW, Kim SC. Use of dong quai(Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate? Menopause. 2005;12: 734-40.

141. Ahn BJ, Kim JD. Functional cosmetics used by various herb. 金龜論叢. 1996;3:357-64.

142. Park SK, Hong SK, Kim HJ, Kim BY, Kim TG, Kang JS, et al. Cosmetic effect of Angelica gigas Nakai Root Extracts. Korean Chem Eng Res. 2009;47:553-7.

143. Chung SH, Kang DK, Min GG, Kim SK, Choi BS. Development of granular tea using dioscorea rhizome, Korean angelica and jujube. Korean J Medicinal Crop Sci. 1998;6:176-80.

144. LEE SM. A study on Qi energy of the Korean tea. Korean J Jungshin Sci. 1997;1:61-9.

145. Kim HS. Effective components and nitrite scavenging ability of root and leaves a Angelica gigas Nakai. Korean J Food Cookery Sci. 2006;22:957-65.

146. Piao XL, Park JH, Cui J, Kim DH, Yoo HH. Development of gas chromatographic/mass spectrometry-pattern recognition method for the quality control of Korean angelica. J Pharm Biomed Anal. 2007;44:1163-7.

147. Lao SC, Li SP, Kan KKW, Li P, Wan JB, Wang YT, et al. Identification and quantification of 13 components in Angelica sinensis(danggui) by gas chromatography-mass spectrometry coupled with pressurized liquid extraction. Anal Chim Acta. 2004;526:131-7.