- P-ISSN 1010-0695
- E-ISSN 2288-3339
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
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Protective Effects of Socheongryong-tang on Elastase-Induced Lung Injury
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.4, pp.83-99
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(2011). Protective Effects of Socheongryong-tang on Elastase-Induced Lung Injury. , 32(4), 83-99.
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Abstract
Objective: This study aimed to evaluate the protective effects of Socheongryong-tang (SCRT) on elastase-induced lung injury. Materials and Methods: The extract of SCRT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: SCRT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, and gene expression of TNF-α and IL-1β in A549cells. SCRT treatment also revealed the protective effect on elastase-induced COPD mice model. This effect was evidenced via histopathological findings including immunofluoresence stains against elastin, collagen, and caspase 3,and protein level of Cdc2, cyclin B1, and phospho-Erk1/2 in lung tissue. Conclusion: These data suggest that SCRT has pharmaceutical properties on COPD. This study provides scientific evidence for the efficacy of SCRT for clinical application to patients with COPD.
- keywords
- Socheongryong-tang, chronic obstructive pulmonary disease, A549 cell, elastase
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