- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Protective Effects of Socheongryong-tang on Elastase-Induced Lung Injury
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.4, pp.83-99
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(2011). Protective Effects of Socheongryong-tang on Elastase-Induced Lung Injury. Journal of Korean Medicine, 32(4), 83-99.
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Abstract
Objective: This study aimed to evaluate the protective effects of Socheongryong-tang (SCRT) on elastase-induced lung injury. Materials and Methods: The extract of SCRT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: SCRT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, and gene expression of TNF-α and IL-1β in A549cells. SCRT treatment also revealed the protective effect on elastase-induced COPD mice model. This effect was evidenced via histopathological findings including immunofluoresence stains against elastin, collagen, and caspase 3,and protein level of Cdc2, cyclin B1, and phospho-Erk1/2 in lung tissue. Conclusion: These data suggest that SCRT has pharmaceutical properties on COPD. This study provides scientific evidence for the efficacy of SCRT for clinical application to patients with COPD.
- keywords
- Socheongryong-tang, chronic obstructive pulmonary disease, A549 cell, elastase
Reference
1
1. Celli BR, MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004;23(6):932-46.
2
2. Kim DS, Kim YS, Jung KS, Chang JH, Lim CM, Lee JH, et al. Prevalence of chronic obstructive pulmonary disease in Korea: a population-based spirometry survey. Am J Respir Crit Care Med. 2005;172:842-7.
3
3. Korea National Statistical Office. Dajeon: Korea National Statistical Office; c1996-[cited 2009 Mar]. Available from: http://www.nso.go.kr
4
4. World Health Report. World Health Organization, Geneva. 2000. Available from URL: http://www.who.int/whr/2000/en/ statistics.htm.
5
5. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007;176(6):532-55.
6
6. Chang J. Pharmacologic treatment of COPD. Tuberc Respir Dis. 2005;59:231-42.
7
7. Lee DJ. The effects of Lonicera japonica on the murine model of Chronic obstructive pulmonary disease. Seoul: Kyung Hee Univ.; 2009.
8
8. Kim KT, Ko H. Effects of Shigyungbanha-tang on the lipopolysaccharide-induced acute lung injury in mice. Kor J Orient Physiol Pathol. 2009; 26:1349-1357.
9
9. Oh JS, Park YC. Protective effects of Gamipalmihwan on elastase-induced apoptosis of A549 cells. J Kor Orient Med. 2010;31(2):137-48.
10
10. Yoon JM, Park YC. Protective effects of Seonpyejeongcheon-tang on elastase-induced lung injury in mice. Kor J Orient Int Med. 2010; 31(1):84-101.
11
11. 장기. 중경전서. 서울: 행림출판사. 1977:460-1.
12
12. 이상인. 방제학. 서울: 영림사. 1995:50.
13
13. 전국한의과대학 폐계내과학교실. 동의폐계내과 학. 서울: 한문화사. 2002:338-46.
14
14. Jung S, Cho SJ, Moon KI, Kim HW, Kim BY, Cho SI. Effects of Socheongryong-tang on immunoglobulin production in asthmatic mice. Kor J Herbology. 2008;23(1):23-8.
15
15. Kim KY, Lee JH, Kim YJ, Choi SY, Kim TH, Lyu YS, et al. Anti-allergic effects of Socheongyoung-tang on RBL-2H3 mast cell and mice-mediated allergy model. 2007;21(5):1260-70.
16
16. Kim HW. Effects of Socheongryong-tang on inflammatory cells in asthmatic mice. Kor J Orient Prevent Med Soc. 2006;10(2):121-9.
17
17. Jeong HJ, Hong MC, Shin MK, Bae HS. Sochungyong-tang, traditional Korean medicine, suppresses Th2 lineage development. Kor J Orient Physiol Pathol. 2005;19(2):380-8.
18
18. Jung JY, Jung HJ, Jung SK, Rhee HK. The inhibitory effects of Socheongryong-tang and Socheongryong-tang plus Sasam (Adenophorae Radix) on the IL-6, IL-8 and GM-CSF mRNA levels in human epithelial cells. J Kor Orient Med. 2003;24(1):74-83.
19
19. Hwang WS, Lee JS, Choi JY, Jung HJ, Rhee HK, Jung SK. Two cases of chronic sinusitis with asthma improved by Socheongryong-tang. J Kor Orient Med. 2003;24(1):207-12.
20
20. Jung SK, Heo TS, Hwang WS, Ju CY, Kim YW, Jung HJ. The effects of Socheongryong-tang on serum IL-4, IL-5, and IFN-r in asthmatic patients. J Kor Orient Med. 2002;23(2):70-7.
21
21. Hwang WS, Jung HJ, Ju CY, Lee JS, Lee KK, Rhee HK, et al. A study on changes in blood eosinophil, serum IgE and T lymphocyte subpopulation after Socheongryong-tang to asthmatic patients. Kor J Orient Int Med. 2002; 23(1):83-90.
22
22. Heo TS, Hwang WS, Ju CY, Jung HJ, Rhee HK, Jung SK. The effects of Socheongryong-tang on pulmonary function and quality-of-life in asthmatic patients. J Kor Orient Med. 2001;22(4):131-41.
23
23. Park YC. Effect of Socheongryong-tang on Punghan and Pungyeol type common cold: a double blind, placebo controlled study. Kor J Orient Physiol Pathol. 2005;19(2):524-9
24
24. Na DG, Lee CJ, Park YC. Effects of Socheongryong-tang and Kamichihyo-san on mucine secretion from airway goblet cells. Kor J Orient Physiol Pathol. 2004;18(3):734-9.
25
25. Kawakami M, Matsuo Y, Yoshiura K, Nagase T, Yamashita N. Sequential and quantitative analysis of a murine model of elastase-induced emphysema. Biol Pharm Bull. 2008;31:1434-8.
26
26. Nakajoh M, Fukushima T, Suzuki T, Yamaya M, Nakayama K, Sekizawa K, et al. Retinoic acid inhibits elastase-induced injury in human lung epithelial cell lines. Am J Respir Cell Mol Biol. 2003;28:296-304.
27
27. Lucey EC, Goldstein RH, Stone PJ, Snider GL. Remodeling of alveolar walls after elastase treatment of hamsters. Results of elastin and collagen mRNA in situ hybridization. Am J Respir Crit Care Med. 1998;158:555-64.
28
28. Molfino NA, Jeffery PK. Chronic obstructive pulmonary disease: Histopathology, inflammation and potential therapies. Pulm Pharmacol Ther. 2007;20(5):462-72.
29
29. Yoo CG. Pathogenesis and pathophysiology of COPD. Kor J Int Med. 2009;77:383-400.
30
30. Abboud RT, Vimalanathan S. Pathogenesis of COPD. Part I. The role of protease-antiprotease imbalance in emphysema. Int J Tuberc Lung Dis. 2008;12(4):361-7.
31
31. Harel S, Janoff A, Yu SY, Hurewitz A, Bergofsky EH. Desmosine radioimmunoassay for measuring elastin degradation in vivo. Am Rev Respir Dis. 1980;122:769-73.
32
32. Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol. 2009;4:435-59.
33
33. Bowler RP, Barnes PJ, Crapo JD. The role of oxidative stress in chronic obstructive pulmonary disease. COPD. 2004;1(2):255-77.
34
34. Cho HY, Kleeberger SR. Genetic mechanisms of susceptibility to oxidative lung injury in mice. Free Radic Biol Med. 2007;42:433-45.
35
35. Gardi C, Arezzini B, Martorana PA. Testing of compounds in models of pulmonary emphysema. Curr Med Chem. 2008;15:803-8.
36
36. Sethi JM, Rochester CL. Smoking and chronic obstructive pulmonary disease. Clin Chest Med. 2000;21:67-86.
37
37. Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science. 1997;277:2002-4.
38
38. Gottlieb DJ, Stone PJ, Sparrow D, Gale ME, Weiss ST, Snider GL, et al. Urinary desmosine excretion in smokers with and without rapid decline of lung function: the Normative Aging Study. Am J Respir Crit Care Med. 1996; 154:1290-5.
39
39. Foronjy R, D’Armiento J. The role of collagenase in emphysema. Respir Res. 2001;2:348-52.
40
40. Uhal BD. Cell cycle kinetics in the alveolar epithelium. Am J Physiol. 1997;272:L1031-L45.
41
41. Draetta G, Beach D. The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle. J Cell Sci Suppl. 1989;12:21-7.
42
42. Draetta G. Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends Biochem Sci. 1990;15:378-83.
43
43. Moreno S, Nurse P. Substrates for p34cdc2: in vivo veritas? Cell. 1990;61:549-51.
44
44. Norbury CJ, Nurse P. Control of the higher eukaryote cell cycle by p34cdc2 homologues. Biochim Biophys Acta. 1989;989:85-95.
45
45. Nigg EA. The substrates of the cdc2 kinase. Semin Cell Biol. 1991;2:261-70.
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