Article Detail

Home > Article Detail
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Effects of Choweseuncheng-tang on Obesity and Hyperlipidemia in High-fat-diet-induced Obese Mice

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.4, pp.37-47







  • Downloaded
  • Viewed

Abstract

Objectives: This study investigated the effects of Choweseuncheung-tang (CWSCT, Tiaoweishengqing-tang) on body weight, serum lipid level, serum insulin level and serum leptin level in high-fat-diet-induced obese mice. Methods: Four-week-old male C57BL/6 mice were randomly divided into three groups (7 mice in each group),including a normal group, control group, and CWSCT group. The normal group was fed a general diet, but the other groups were fed a high fat diet. The CWSCT group was administered CWSCT for 4 weeks. Animals were weighted weekly and blood lipids, insulin and leptin levels were measured after 4 weeks. Results: The results were as follows. 1. In the CWSCT group, compared with the control, body weight gain was significantly inhibited. 2. In the CWSCT group, compared with the control, the level of HDL cholesterol in serum increased significantly. 3. In the CWSCT group, compared with the control, the ratio of total cholesterol to HDL cholesterol decreased significantly. 4. In the CWSCT group, compared with the control, the elevation of serum leptin level was significantly inhibited. Conclusions: Choweseuncheung-tang treatment has inhibitory effects on obesity and hyperlipidemia in high-fat-dietinduced obese mice.

keywords
Choweseuncheung-tang, obesity, hyperlipidemia


Reference

1

1. Lee BJ, Ryu JH, Kim JW, Park JH, Park JW. The anti-obesity effects of Gambi-hwan extract on obese rats induced by high-fat diet through the expression of UCP-1 and PPAR-δ. Korean Journal of Oriental Medicine. 2007;28(4): 136-147.

2

2. Chon JW. Anti-obesity effect of Methanol Extract of Gromwell(Lithospermum erythrorhizon Sieb. et Zucc) in 3T3-L1 cells and obese mice models[dissertation]. Suwon: Kyung-hee Univ.; 2010.

3

3. Korean society for the study of obesity. Clinical bariatrics. 3rd ed. Seoul:Korea medical book. 2008:175-179, 266, 291.

4

4. Gail WL. Obesity:Dietary and Developmental influences. CRC/Taylor and Ftancis. 2006:1

5

5. 金達鎬, 李鍾馨 編譯. 注解補注 黃帝內經 素問 (上). 서울:의성당. 2001:652, 974.

6

6. 許浚. 東醫寶鑑. 서울:법인문화사. 2002:741, 923.

7

7. 翁維良, 焦東海. 實用中西醫結合肥胖病學. 北京: 學苑出版社. 1997:6-7, 34-39, 142-143.

8

8. Hwang SJ, Song TW, Oh MS. The inhibitory effects of Bangpoongtongsung-san on the obese gene and obese inhibitory bout obese-mouse induced by high ft diet. J Korean Oriental Med. 2006;27(1):11-22.

9

9. Lee DH, Kim DG. The effets of Sobieum on decrease of body mass index(BMI) and obesity index of obese children. J Korean Oriental Pediatrics. 2009;23(1):195-203.

10

10. Jeong JH, Kim SS, Shin HD. Effects of Soshihotang on the histological changes in liver and epididymal fat and the biochemical changes of lipid metabolism in obese rats induced by high fat diet. Dissertations Collection of Collage of Oriental Medicine, Kyung-hee University. 1997; 20(2):96-118.

11

11. Song JC, Kim KS. Effects of Chegameyiin-tang extract on the change of the weight, tissue in epididymal fat, blood, leptin and uncoupled protein in visceral fat of obesity rats induced by high fat diet. Journal of Korean Oriental Association for Study of Obesity. 2001;1(1): 85-100.

12

12. Kim JJ, Lim HH. Effects of Handayulso-tang for Taeum-in on the body weight and lipid metabolism of induced obesity rats. Journal of Korean Oriental Association for Study of Obesity. 2001;2(2):95-104.

13

13. Cho SW, Park SS. Effects of Taeyeumjoweetang on loss in body weight, plasma lipids and UCP1 revelation of fated white rats. J Korean Oriental Med. 2004;25(2):87-97.

14

14. 朱震亨. 丹溪医集. 第 2版. 北京:人民衛生出版社. 2003:225.

15

15. 陳文塏, 陳嘉媛. 高脂血症的中医防治. 北京:中醫 古籍出版社. 1988:9-20.

16

16. Korean society for the study of obesity. Diagnosis and treatment of obesity. Korean society for the study of obesity. 2003:27-28.

17

17. 金達鎬 編譯. 主解補注 黃帝內經 靈樞. 서울:의성 당. 2002:1120.

18

18. Lim J, Lee IS, Koh BH, Song IB, Lee SK. A study on the Sasang constitutional characteristics of obese middle-aged women. J of Sasang Constitutional Medicine. 2004;16(3):59-69.

19

19. Son BW. Four-Constitution Medicine. Seoul: Haenglim. 2002:474-475, 492-494.

20

20. Lee GJ, Kim KY, Jeon BH. Effects of Taeyeumjowee-tang on the obesity of mouse nd induced adipocyte 3T3-L1. Korean J. Oriental Medical Pathology. 1996;10(1):88-98.

21

21. Jang YJ, Cho JH, Song BJ. Effect of Taeyeumjowee-tang and electroacupuncture combined-therapy on. J Korean Oriental Association for Study of Obesity. 2001;1(1):77-83.

22

22. Kwon MW, Km IH, Park EJ, Kang BG. The clinical study on 66 cases of obese patient treated by Kamijowisengchung-tang & acupuncture. J Korean Oriental Pediatrics. 2001;15(2):43-51.

23

23. Seo DM, Lee SH, Lee JD. Clinical observation on effects and adverse effects of Choweseunchengtang on obesity patients. J Korean Acupuncture & Moxibustion Society. 2005;22(3):145-153.

24

24. Oriental pharmacology textbook compilation committee. Oriental Pharmacology. 3rd rev. ed. Seoul:Sinilbooks. 2010:273-275.

25

25. Shirin HR, Neda N, Bagher L, Mohammad A. A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity. World J Gastroenterol. 2009;15(25): 3073-3085.

26

26. Lee HJ, Shin GJ, Park SH, Cho HK. Insulin resistance and visceral fat obesity in hyperlipidemia. Korean Circulation J. 1999;29(7):673-679.

27

27. Baldizán G, Oviedo M, Michelangeli C, Vargas RE. Effects of peach palm oil on performance, serum lipoproteins and haemostasis in broilers. Br Poult Sci. 2010 Dec;51(6):784-790.

28

28. Lee SK, So SH, Hwang EI, Koo BS, Han GH, Ko SB et al. Effect of Ginseng and herbal plant mixtures on anti-obesity in obese SD rat induced by high fat diet. J Korean Soc Food Sci Nutr. 2008;37(4):437-444.

29

29. Kinosian B, Glick H, Preiss L, Puder KL. Cholesterol and coronary heart disease: predicting risks in men by changes in levels and ratios. J Investig Med. 1995;43(5):443-450.

30

30. Bruce K, Henry G, Gonzalo G. Cholesterol and coronary heart disease: predicting risks by levels and ratios. Ann Intern Med. 1994;121:641-647.

31

31. Woods SC, Seeley RJ, Rushing PA, DD’Alessio, PTso. A controlled high-fat diet induces an obese syndrome in rats. J. Nutrition. 2003;133:1081- 1087.

32

32. Korean endocrine society. Textbook of endocrinology and metabolism. 2nd rev. ed. Seoul:Koonja. 2011:825.

상단으로 이동

Journal of Korean Medicine