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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Effect of Jaeumgeonbigagamtang (JGT) on Restraint-induced Oxidative Stress in Mouse Brain

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.6, pp.41-53
Jung-Hun Yoon (DaejeonUniversity)
Joung-Jo An (Daejeon University)
Hyun-Kyung Jo (DaejeonUniversity)



Ho-Rhyong Yoo (DaejeonUniversity)
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Abstract

Objectives: This study was performed to investigate the effect of Jaeumgeonbigagamtang (JGT) onrestraint-induced oxidative stress in the mouse brain. Methods: After treatment with JGT, CBC, ROS, MDA, TAC, SOD, activity of catalase, and total GSH content were analyzed. Results: JGT had a strong antioxidant activity by in vitro assay as presented GEAC. JGT treatment significantly ameliorated decrease of blood WBC and increase of platelet count. JGT (50㎎/㎏) treatment significantly ameliorated increase of MDA and GSH content level in brain tissue. JGT (100㎎/㎏) treatment significantly ameliorated increase of MDA and activity of TAC level in brain tissue. JGT (200㎎/㎏) treatment significantly ameliorated increase of ROS, MDA, activity of TAC level and depletion of catalase level in brain tissue. Conclusion: The present study demonstrated antioxidant activity in brain tissue. This result would be consistent with the long clinical efficacy of JGT, and this finding may provide a strong possibility of JGT as a drug candidate for brain-specific multiple disorders and symptoms.

keywords
Jaeungeonbigagamtang (JGT), oxidative stress, antioxidant activity, malondialdehyde (MDA)


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