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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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Palmul-tang, a Traditional Herbal Formula, Protects against Ethanol-induced Acute Gastric Injury in Rats

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.6, pp.74-84
In-Sik Shin (Korea Institute of Oriental Medicine)
이미영 (한국한의학연구원)
서창섭 (한국한의학연구원)
임혜선 (한국한의학연구원)
Jung-Hoon Kim (Korea Institute of Oriental Medicine)
Woo-Young Jeon (Korea Institute of Oriental Medicine)
신현규 (한국한의학연구원)
In-Sik, S. , 이미영, 서창섭, 임혜선, Jung-Hoon, K. , Woo-Young, J. , & 신현규. (2011). . 대한한의학회지, 32(6), 74-84.
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Abstract

Objectives: Palmul-tang (hachimotsu-to in Japanese and bawu-tang in Chinese) is a mixture of eight herbs. It is traditionally used for the treatment of anemia, anorexia, general weakness, and female infertility in China, Japan, and Korea. In this study, we investigated the protective effects of Palmul-tang water extract (PTE) against ethanol-induced acute gastric injury in rats. Material and Methods: Acute gastric lesions were induced by intragastric administration of 5mL/kg body weight of absolute ethanol to each rat. Control group rats were given PBS orally and the ethanol group (EtOH group) received absolute ethanol (5mL/kg) by oral gavage. The positive control group and the PTE group were given oral doses of omeprazole (50mg/kg) or PTE (400mg/kg), respectively, 2 h prior to the administration of absolute ethanol. The stomach of each animal was excised and examined for gastric mucosal lesions. To confirm the protective effects of PTE, we evaluated the degree of lipid peroxidation, the level of reduced glutathione (GSH), and the activities of the antioxidant enzymes catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase in the stomach. Results: PTE reduced ethanol-induced hemorrhage and hyperemia in the gastric mucosa. PTE reduced the increase in lipid peroxidation associated with ethanol-induced acute gastric lesions and increased mucosal GSH content and the activities of antioxidant enzymes. Conclusion: These results indicate that PTE protects gastric mucosa against ethanol-induced acute gastric injury by increasing antioxidant status. We suggest that PTE could be developed as an effective drug for the treatment of acute gastric injury.

keywords
Palmul-tang, herbal formula, ethanol, acute gastric injury, antioxidative effect


참고문헌

1

1. Johansen JS, Harris AK, Rychly DJ, Ergul A. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovascul Diabetol. 2005; 4(1):5.

2

2. Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T.D., Mazur, M., Telser, J., 2007. Free radicals and antioxidants in normal physiological function and human disease. Int J Biochem Cell Biol. 2007; 39(1), 44-84.

3

3. Sener-Muratoglu GS, Paskaloglu K, Arbak S, Hurdag C, Ayanoglu-Dulger G. Protective effects of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats. Dig Dis. Sci. 2001; 46(2):318-30.

4

4. Suresh MV, Sreeranjit Kumar CV, Lal JJ, Indira M. Impact of massive ascorbic acid supplementation on alcohol induced oxidative stress in guinea pigs. Toxicol let. 1999; 104(3):221-9.

5

5. Sugimoto N, Yoshida N, Yoshikawa T, Nakamuara Y, Ichikawa H, Naito Y, et al. Effect of vitamin E on aspirin-induced gastric mucosal injury in rats. Dig Dis Sci. 2000; 45(3):599-605.

6

6. Ozdil S, Yanardag R, Koyuturk M, Bolkent S, Arbak S. Protective effects of ascorbic acid, DL-alpha-tocopherol acetate, and sodium selenite on ethanol-induced gastric mucosal injury of rats. Biol Trace Ele Res. 2004; 99(1-3):173-89.

7

7. Medeiros JV, Gadelha GG, Lima SJ, Garcia JA, Soares PMG, Santos AA, et al. Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats. Br J Pharmacol. 2008; 153(4): 721-727.

8

8. Silva MI, Moura BA, Neto MR, Tome Ada R, Rocha NF, de Carvalho AM, et al. Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanism of action. Naunyn Schmiedeberg’s Arch Pharmacol. 2009; 380(3):233-45.

9

9. Koyuturk M, Bolkent S, Ozdil S, Arbak S, Yanardag R. The protective effect of vitamin C, vitamin E and selenium combination therapy on ethanol-induced duodenal mucosal injury. Hum Exp Toxicol. 2004; 23(8):391-8.

10

10. Tuorkey M, Karolin K. Anti-ulcer activity of curcumin on experimental gastric ulcer in rats and its effect on oxidative stress/antioxidant, IL-6 and enzyme activities. Biomed Environ Sci. 2009; 22(6):488-95.

11

11. Joo JM, Kim DC, Baek SH, Kim EH. The effect of Palmultang on the ovarian functions and differential gene expression of caspase-3, MARK and MPG in female mice. J Orien Obstet Gynecol. 2007; 20(4):91-110.

12

12. Heo MK, Hong HW, Kam CW, Park DI. Experiment study on the anti-allergic effects of Palmultang. Korean J Oriental Physiology & Pathology. 2003; 17(4):1075-81.

13

13. Lim EK, Shin SH. Protective effects of Palmul-tang on hypoxia-induced apoptosis in H9c2 cardiomyoblast cells. J Korean Oriental Med. 2004; 25(2):67-76.

14

14. Li CQ, He LC, Jin JQ. Atractylenolide I and atractylenolide III inhibit lipopolysaccharideinduced TNF-alpha and NO production in macrophages. Phytother Res. 2007; 21(4):347-353.

15

15. Cha JY, Ahn HY, Moon HI, Jeong YK, Cho YS. Effect of fermented Angelicae gigantis radix on carbon tetrachloride-induce hepatotoxicity and oxidative stress in rats. Immunopharmacol Immunotoxicol. 2011; In press.

16

16. Kim YO, Kim HJ, Kim GS, Park HG, Lim SJ, Seong NS, et al. Panax ginseng protects against global ischemia injury in rat hippocampus. J Med Food. 2009; 12(1):71-6.

17

17. Yokozawa T, Cho EJ, Rhyu DY, Shibahara N, Aoyagi K. Glycyrrhizae radix attenuates peroxynitrite- induced renal oxidative damage inhibition of protein nitration. Free Radic Res. 2005; 39(2): 203-11.

18

18. Rios JL. Chemical constituents and pharmacological properties of Poria cocos. Planta Med. 2011; 77(7):681-91.

19

19. Okubo T, Nagai F, Seto T, Satoh K, Ushiyama K, Kano I. The inhibition of phenylhydroquinoneinduced oxidative DNA cleavage by constituents of Moutan cortex and Paeoniae radix. Biol Pharm Bull. 2000; 23(2):199-203.

20

20. Sakurai T, Sugawara H, Saito K, Kano Y. Effects of the acetylene compound from Atractylodes rhizome on experimental gastric ulcers induced by active oxygen species. Biol Pharm Bull. 1994; 17(10):1364-8.

21

21. Goso Y, Ogata T, Ishihara K, Hotta K. Effects of traditional herbal medicine on gastric mucin against ethanol-induced gastric injury in rats. Comp Biochem Physiol C Pharmacol Toxcicol Endocrinol. 1996; 113(1):17-21.

22

22. Yeo M, Kim DK, Cho SW, Hong HD. Ginseng, the root of Panax ginseng C.A. Meyer, protects ethanol-induced gastric damages in rat through the induction of cytoprotective heat-shock protein 27. Dig Dis Sic. 2008; 53(3):606-13.

23

23. Li XL, Zhou AG, Zhang L, Chen WJ. Antioxidant status and immune activity of glycyrrhizin in allergic rhinitis mice. Int J Mol Sci. 2011; 12(2): 905-16.

24

24. Kim HY, Park J, Lee KH, Lee DU, Kwak JH, Kim YS, et al. Ferulic acid protects against carbon tetrachloride-induced liver injury in mice. Toxicology. 2011; 282(3);104-11.

25

25. Guan Y, Li FF, Hong L, Yan XF, Tan GL, He JS, et al. Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury. Fundam Clin Pharmacol. 2011; in press.

26

26. Chen T, Guo ZP, Jiao XY, Zhang YH, Li JY, Liu HJ. Protective effects of peoniflorin against hydrogen peroxide-induced oxidative stress in human umbilical vein endothelial cells. Can J Physiol Pharmacol. 2011; 89(6):445-53.

27

27. Yano S, Haradam M, Watanabe K, Nakamaru K, Hatakeyama Y, Shibata S, et al. Antiulcer activities of glycyrrhetinic acid derivatives in experimental gastric models. Chem Pharm Bull. 1989; 37(9):2500-4.

28

28. Asai M, Kawashima D, Katagiri K, Takeuchi R, Tohnai G, Ohtsuka K. Protective effect of a molecular chaperone inducer, paeoniflorin, on the HCl- and ethanol triggered gastric mucosal injury. 2011; 88(7-8):350-7.

29

29. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology. 1979; 77(3):433-43.

30

30. Dunnett CW. New tables for multiple comparisons with control. Biometrics. 1964; 20:482-91.

31

31. Vaca CE, Wilhelm J, Harms-Ringdahl M. Studies on lipid peroxidation in rat liver nuclei and isolated nuclear membranes. Biochim Biophys Acta. 1988; 958(3):375-87.

32

32 Kadiska MB, Gladen BC, Baird DD, Dikalov AE, Sohal RS, Hatch GB, et al. Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl4 poisoning. Free Rad Biol Med. 2000; 28(6):838-45.

33

33. Kanter M, Demir H, Karakaya C, Ozbek H. Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats. World J Gastroenterol. 2005; 11(42):6662-6.

34

34. Chelikani P, Fita I, Loewen PC. Diversity of structures and properties among catalase. Cell Mol Life Sci. 2004; 61(2):192-208.

35

35. Douglas KT. Mechanism of action of glutathionedependent enzymes. Adv Enzymol Relat Areas Mol Biol. 1987; 59:103-67.

36

36. Sheehan D, Meade G, Foley VM, Dowd CA. Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J. 2001; 360(1):1-16.

37

37. Meister A. Glutathione metabolism and its selective modification. J Biol Chem. 1988; 263(33):17205-8.

38

38. Rao ChV, Ojha SK, Radhakrishnan K, Govindarajan R, Rastogi S, Mehrotra S, et al. Antiulcer activity of Uteria salicifolia rhizome extract. J Ethnopharmacol. 2004; 91(2-3):243-9.

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