- P-ISSN 1010-0695
- E-ISSN 2288-3339
Objectives: This study researched the effect of Gamisoyo-san intravenous pharmacopuncture on restoration of liver function after partial hepatectomy in SD rat. Methods: Twelve rats were randomly divided into three groups: control group (n=4) underwent partial hepatectomy, saline group (n=4) was injected 1㎖ saline after partial hepatectomy, Gamisoyo-san group (n=4) was injected with 10㎎/㎏ Gamisoyo-san after partial hepatectomy. Liver function and liver regeneration ratio were measured on the seventh day after partial hepatectomy. Results: The results show that the AST, AST and ALT level in Gamisoyo-san group was significantly lower than those of control group and saline group(P<0.05)Conclusion: In partial hepatectomy model, Gamisoyo-san intravenous pharmacopuncture seems to significantly promote the restoration of liver function.
1. Arthur C, John E. Textbook of Medical Physiology. 11th ed. Philadelphia: Elsevier Saunders. 2005:859-864.
2. Credland N. Interpreting Blood Results - Liver Function Tests. Dermatological Nursing. 2014; 13(2):42-45.
3. Ministry of Health & Welfare. The Fifth Korea National Health and Nutrition Examination Survey(KNHANES V-2). Seoul:Korea Centers for Disease Control and Prevention. 2011:548 -693.
4. Vinay K, Abul K, John C. Robbins Basic Pathology. 9th ed. Philadelphia:Elsevier Science Health Science div. 2013:637.
5. Llovet JM, Burroughs A, Bruix J. Hepatocellular Carcinoma. Lancet. 2003;362(9399):1907–1917.
6. Jung KW, Won YJ, Kong HJ, Oh CM, Lee DH, Lee JS. Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2011. Cancer Research and Treatment. 2014;46(2): 109-123.
7. Bae SH. Up-to-date Information for Hepatocellular Carcinoma Treatment. J Korean Med Assoc. 2008;51(5):457-474.
8. Yoo HC. Surgical Strategies in hepatocarcinoma treatment. Korean J Gastroenterol. 2007;49(4): 226-235.
9. George K. Liver Regeneration after Partial Hepatectomy. Am J Pathol. 2010;176(1):2-13.
10. Lee S, Lee M. Present status of Chinese medicine intervention for treatment of the liver cancer: application base and clinical research. Beijing J Tradit Chin Med. 2009;28(2):145-147.
11. Bae SH, Park SE, Kang CW, Hong SH. Safety of Korean Herbal Medicine Used with Western Medicine on Liver Function: Prospective Observational Study. Korean J Orient Int Med. 2013;34(2):192-203.
12. Yun YJ, Shin BC, Lee MS, Cho SI, Shin WJ, Park HJ, et al. Korean Herbal Medicine on Liver Function: A Systematic Review in Korean Literature. Korean J Orient Int Med. 2009;30(1): 153-172.
13. Zhao XX. Studiess of Chinese Herbal Injections. Guangzhou:Guangdong Science & Technology Press. 2000:3-4.
14. Zhou JM, Zhang JQ. Pharmacology and Application of Chinese Patent Drug. Shanghai: Fudan University Press. 2003:20.
15. Bang SH, Kwon KR, Yoo HS. Two Cases of Non-Small Cell Lung Cancer Treated with Intravenous Cultivated Wild Ginseng Pharmacopuncture. J Pharmacopunct. 2008; 11(2):13-19.
16. Lee DN, Yang WM, Lee TK, Lim EM. A Study of Sayuk-san and Soyo-san for Clinical Using. J Korean Med Obstet Gynecol. 2000;13(1): 484-499.
17. Lee SH, Kim KS, Yun JM, Ko HN, Kim LH, Rhee YJ, et al. Case Report on Three Cases of Postoperative Pain after Thyroidectomy Treated with Gamisoyo-san. Korean J Orient Physiol Pathol. 2012;26(5):793-796.
18. Kim HJ. Effect of "Kami-Soyo-San" Ex. on the Hepatic Damages induced by CCl4 in rats[dissertation]. Gwangju: Chosun Univ.; 1986.
19. Gaub J, Iverson J. Rat liver regeneration after 90% partial hepatectomy. Hepatology. 1984;4: 902-904.
20. Ramzi S, Vinay K, Nelson F, Stanley L, Abul K. Robbins and Cotran pathologic basis of disease. 7th ed. Philadelphia:Elsevier Saunders. 2005:878.
21. Lee WB, Ryu CS, Kim KY. Evidences of the Intravascular Erythropoiesis in Human Fetal Liver. Korean J Anat. 1995;28(4):351-364.
22. Gerard J, Bryan D. Principles of anatomy and physiology. 12th ed. Hoboken:Wiley. 2009:945- 949.
23. Park BG, Yoon SG, Lee HS, Chang JG, Maeng JH, Lee GH, et al. Epidemiological comparison of viral hepatitis-hepatocellular carcinoma (HCC) and non viral hepatitis-hepatocellular carcinoma (HCC). Korean J Epidemiol. 2003;25(1):32-38.
24. Centers for Disease Control and Prevention. Surveillance for Viral Hepatitis – United States 2011. Atlanta:Centers for Disease Control and Prevention. 2011.
25. Kim HJ, Hwang YJ, Kim JY, Kwon HJ, Kim GS, Chun JM, et al. Comparison of Surgical Outcomes and Long-term Survival between Limited and Major Hepatic Resection for Hepatocellular Carcinoma Less than 5 cm. J Korean Surg Soc. 2010;78:29-34.
26. Lin TY, Chen CC. Metabolic function and regeneration of cirrhotic and non-cirrhotic livers after hepatic lobectomy in man. Ann Surg. 1965;162(6):959-972.
27. Takenaka K, Kanematsu T, Fukuzawa K, Sugimachi K. Can hepatic failure after surgery for hepatocellular carcinoma in cirrhotic patients be prevented?. World J Surg. 1990;14(1):123 -127.
28. Kim GS, Lee SM, Hong SH, Joo HJ. Perioperative Risk Factors of the Hepatic Resection. Ann Surg Treat Res. 1998;55(4): 556-563.
29. Baek DK. The Clinical Study of Two Severe Menopausal Disorder Patients Treated by Gamisoyo-san. Herbal Formula Science. 2012; 20(2):199-211.
30. Park SW. Antidepressant Action of Kami -shoyosan[dissertation]. Busan: Inje Univ.; 2004.
31. Yang SK, Yong JS. Perception of Artificial Hydration for Terminally Ill Cancer Patients: Patients, Families and General Public. Korean J Hosp Palliat Care. 2009;12(4):220-227.
32. Yang GM. Pharmacy of Chinese Medicine. Beijing:People's Medical Publishing House. 2010:156-184.
33. Kim K, Choi YS, Joo JC, Moon G. A Case Report for Lung Cancer Patient Showing Remission Treated with Cultivated Wild Ginseng Pharmacopuncture. J Pharmacopunct. 2011;14(4): 33-37.
34. Han DH. The significance of the actual half-life of serum alpha-fetoprotein as a predictor for recurrence after curative hepatectomy in patients with hepatocellular carcinoma[dissertation]. Seoul: Yonsei Univ.; 2011.
35. Johnson DC. Exotic Animal Companion Medicine Handbook for Veterinarians. West Palm Beach: Zoological Education Network. 1996:9-98.
36. Jeong SO. penta-O-galloyl-β-D-glucose up -regulates heme oxygenase-1 expression by stimulating Nrf2 nuclear translocation in an extracellular signal-regulated kinase-dependent manner in HepG2 cells[dissertation]. Jeonju: Chonbuk Univ.; 2006.
37. Cheng YY, Chan YS, Choang KF, Chang HM. Effect of geniposide on acute jaundice in rats caused by ANIT poisoning. Acta Pharmacol Sin. 1986;7(1):69-72.
38. Matsumi Y, Kenzo C. Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthase-expressing cells. Eur J Pharmacol. 2008;581(3):255-261.
39. Na JX, Park EJ, Sohn DH, Ko GI. Hepatoprotective and antifibrotic effects of extracts from Persicae Semen. Herbal Formula Science. 2004;12(2):109~117.
40. Lim JG, Moon JJ. Experimental Studies on the Effect of Dangkwisoo-San on the CCl4 –Induce dliver Damage in Albino-Rats. K.H.University Orient Med J.1982;5:191-208.