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- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The effects of Atractylodes japonica Koidz. on type 2 diabetic rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2015, v.36 no.1, pp.75-85
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(2015). The effects of Atractylodes japonica Koidz. on type 2 diabetic rats. Journal of Korean Medicine, 36(1), 75-85.
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Abstract
Objectives: Type 2 diabetes mellitus is a metabolic disease characterized by insulin resistance and high blood glucose level from progressive insulin secretory defect. The rhizome of Atractylodes japonica Koidz. (AJ) has been used for treatment of retention of water in oriental medicine. The aim of this study is to examine the effects of AJ on type 2 diabetes rats. Methods: Type 2 diabetes was induced by 60% high fat diet and low dose streptozotocin. Rats were divided into 4 groups (n = 6); Nor (normal control group), Con (diabetic group treated with vehicle), Met (diabetic group treated with 200 mg/kg metformin) and AJ (diabetic group treated with 100 mg/kg AJ). The body weights and food intakes were measured during the treatment period. After 4 weeks treatment, blood glucose level, HOMA-IR, and protein expressions of IRS-1, p-IRS-1, PPAR-γ, and GLUT4 were measured, and histopathological examination of beta cell was performed. Results: Compared with the control group, blood glucose level and HOMA-IR were reduced in rats treated with AJ. Impaired beta cells in pancreas of rats were recovered and phosphorylation of IRS-1 was increased in rats treated with AJ. And also, protein expressions of PPAR-γ and GLUT4 were increased by treatment of AJ. Conclusions: The results suggest that Atractylodes japonica Koidz. may have anti-diabetic effect on type 2 diabetic rats through regulation of blood glucose level and insulin resistance. Therefore Atractylodes japonica Koidz. may have positive effects on patients with type 2 diabetes.
- keywords
- Atractylodes japonica Koidz., type 2 diabetes, insulin resistance, blood glucose, HOMA-IR, PPAR-γ
Reference
1
1. Mccarthy MI. Genomics, type 2 diabetes, and obesity. The New England Journal of Medicine. 2010;363(24):2339-2350.
2
2. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121): 840-846.
3
3. Korean diabetes association. Korea centers for disease control and prevention. Diabetes fact sheet in korea 2012.
4
4. Alberti KGMM, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation. Diabetic medicine: a journal of the British Diabetic Association. 1998;15(7):539-553.
5
5. American diabetes association. Standards of medical care in diabetes-2014. Diabetes Care. 2014;37(1):S14-S80.
6
6. Cheng AYY, Fantus IG. Oral antihyperglycemic therapy for type 2 diabetes mellitus. Canadian Medical Association journal. 2005;172(2):213 -226.
7
7. Yale JF. Oral antihyperglycemic agents and renal disease: New agents, new concepts. Journal of the American Society of Nephrology. 2005;16:S7-S10.
8
8. Doo HK. Internal Medicine of Kidney System. Seongbosa. 2003:1131.
9
9. Kang SB, Kim GC. A pathological approach about symptoms of So-gal. The Journal of East-West Medicines. 1998;23(4):21-40.
10
10. Kang SB. The comparative study between the transformations of sogal and the complications of diabetes mellitus. The Journal of Korean Oriental Medical Society. 1998;19(2):137-152.
11
11. Editing commission of herbal medicine. Herbal medicine. Youngrimsa. 2007:331-332.
12
12. Ahn DK. Illustrated guide to korean herbal medicine. Kyohaksa. 2008:384.
13
13. Heo J. Donguibogam. Bubinmunhwasa. 2007: 1952.
14
14. Choi KH, Jeong SI, Lee JH, Hwang BS, Kim SJ, Lee S, et al. Pharmacological mechanism responsible for the Atractylodes japonica -induced distal colonic contraction in rats. Phytomedicine. 2011;18:408-413.
15
15. Han YK, Jung HW, Park YK. The roots of Atractylodes japonica Koidzumi promote adipogenic differentiation via activation of the insulin signalong pathway in 3T3-L1 cells. BMC Complementary and Alternative Medicine. 2012;12:154
16
16. Han HK, Yoon SJ, Kim GH. Effects of compositae plants on plasma glucose and lipid level in streptozotocin induced diabetic rats. Journal of Korean Food Science and Nutrition. 2009;38(6):674-682.
17
17. Chen F, Xiong H, Wang J, Ding X, Shu G, Mei Z. Antidiabetic effect of total flavonoids from Sanguis draxonis in type 2 diabetic rats. Journal of ethnopharmacology. 2013;149(3):729-736.
18
18. Vogeser M, König D, Frey I, Predel HG, Parhofer KG, Berg A. Fasting serum insulin and the homeostasis model of insulin resistance (HOMA-IR) in the monitoring of lifestyle interventions in obese persons. Clinical Biochemistry. 2007;40(13-14):964-968.
19
19. Catalano PM, Presley L, Minium J, Mouzon SHD. Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care. 2009;32(40): 1076-1080.
20
20. Han YK, Park YK. Effect of Atractylodis Rhizoma Alba water extract on streptozotocin -induced diabetes in rats. Journal of Korean Herbology. 2011;26(4):23-30.
21
21. Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. The Lancet. 2011; 378(9):169-181.
22
22. Adefegha SA, Oboh G, Adefegha OM, Boligon AA, Athayde ML. Antihyperglycemic, hypolipidemic, hepatoprotective and antioxidative effects of dietary clove (Szyzgium aromaticum) bud powder in a high-fat diet/streptozotocin-induced diabetes rat model. Journal of the science of food and agriculture. 2014;94(13):2726-2737.
23
23. Colberg SR, Albright AL, Blissmer BJ, Braun B, Chasan-Taber L, Fernhall B, et al. Exercise and Type 2 Diabetes. Medicine and Science in Sports and Exercise. 2010;42(12):2282-2303.
24
24. Hong SM, Park JH, Lim YH, Park YS, Kim DS, Choi WH, et al. The relationship between diabetic retinopathy and macrovascular complication in patients with type 2 diabetes. The Korean Journal of Medicine. 2011;81(3): 351-358.
25
25. Chae HJ, Lee IS, Moon HY. Effects of Schizandra Cchinensis fruit extract on the hyperglycemia and hyperlipemia in streptozotocin -induced diabetic rats. Korean Society for Biotechnology and Bioengineering Journal. 2011;26(2):126-130.
26
26. Choi ES, Rhee EJ, Kim JH, Won JC, Park CY, Lee WY, et al. Insulin sensitivity and insulin secretion determined by homeostasis model assessment and future risk of diabetes mellitus in korean men. Diabetes and Metabolism Journal. 2008;32(6):498-505.
27
27. Han JS, Back SH, Hur JU, Lin YH, Gildersleeve R, Shan J, et al. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature cell biology. 2013; 15(5):481-490.
28
28. Dor Y, Glaser B. Beta-cell differentiation and type 2 diabetes. The New England Journal of Medicine. 2013;368(6):572-573.
29
29. Imamura F, Mukamal KJ, Meigs JB, Luchsinger JA, Ix JH, Siscovick DS, et al. Risk factors for type 2 diabetes mellitus preceded by beta-cell dysfunction, insulin resistance, or both in older adults. American Journal of Epidemiology. 2013;177(12):1418-1429.
30
30. Ryu HS, Park SY, Ma D, Zhang J, Lee W. The Induction of MicroRNA Targeting IRS-1 Is Involved in the Development of Insulin Resistance under Conditions of Mitochondrial Dysfunction in Hepatocytes. PloS one. 2011; 6(3):e17343.
31
31. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001;.414(6865):799-806.
32
32. Hemi R, Yochananov Y, Barhod E, Kasher MM, Karasik A, Tirosh A, et al. p38 mitogen-activated protein kinase-dependent transactivation of ErbB receptor family: a novel common mechanism for stress-induced IRS-1 serine phosphorylation and insulin resistance. Diabetes. 2011;60(4):1134-1145.
33
33. Ohshima K, Mogi M, Jing F, Iwanami J, Tsukuda K, Min LJ, et al. Direct angiotensin Ⅱ type 2 receptor stimulation ameliarates insulin resistance in type 2 diabetes mice with pparγ activation. PloS one. 2012;7(11):e48387.
34
34. Olson AL, Pessin JE. Structure, function, and regulation of the mammalian facilitative glucose transporter gene family. Annual review of nutrition. 1996;16:235–256.
35
35. Cline GW, Petersen KF, Krssak M, Shen J, Hundal RS, Trajanoski Z, et al. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. The New England Journal of Medicine. 1999;341(4):240–246.
36
36. Kainulainen H, Breiner M, Schurmann A, Marttinen A, Virjo A, Joost HG. In vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT4 in heart and various types of skeletal muscle from streptozotocin-diabetic rats. Biochimica et Biophysica Acta. 1994; 1225(3):275–282.
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