Journal of the Korean Association of Oral and Maxillofacial Surgeons
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ISSN : 2234-7550
The role of nuclear factor I-C in tooth and bone development
Journal of the Korean Association of Oral and Maxillofacial Surgeons / Journal of the Korean Association of Oral and Maxillofacial Surgeons, (P)2234-7550; (E)2234-5930
2017, v.43 no.2, pp.63-69
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(2017). The role of nuclear factor I-C in tooth and bone development. Journal of the Korean Association of Oral and Maxillofacial Surgeons, 43(2), 63-69.
Abstract
Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Krüppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.
- keywords
- Nuclear factor I-C, Dentinogenesis, Osteogenesis, Osteoporosis
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