Journal of the Korean Association of Oral and Maxillofacial Surgeons
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ISSN : 2234-7550
A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report
Journal of the Korean Association of Oral and Maxillofacial Surgeons / Journal of the Korean Association of Oral and Maxillofacial Surgeons, (P)2234-7550; (E)2234-5930
2017, v.43 no.4, pp.272-275
Massimo Viviano (Dentistry Clinic)
Alessandra Addamo (Dentistry Clinic)
Serena Cocca (University of Siena)
Alessandra Addamo (Dentistry Clinic)
Serena Cocca (University of Siena)
Massimo,
V.
, Alessandra,
A.
, &
Serena,
C.
(2017). A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report. Journal of the Korean Association of Oral and Maxillofacial Surgeons, 43(4), 272-275.
Abstract
Bisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we report a case of BRONJ with a particularly unfavor-able course due to cervical inflammation that developed into necrotizing fasciitis, followed by multiorgan involvement leading to septic shock and death.
- keywords
- Bisphosphonate-associated osteonecrosis of the jaw, Sepsis, Necrotizing fasciitis, Jaw fractures
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