Journal of the Korean Association of Oral and Maxillofacial Surgeons
- P-ISSN2234-7550
- E-ISSN2234-5930
- SCOPUS, KCI, ESCI
ISSN : 2234-7550
Undifferentiated pleomorphic sarcoma of the mandible
Wanessa Miranda-Silva (Hospital Sírio Libanês)
Felipe Paiva Fonseca (Universidade Federal de Minas Gerais)
Claudia Regina Gomes Cardim Mendes de Oliveira (Hospital Sírio Libanês)
Eduardo Rodrigues Fregnani (Hospital Sírio Libanês)
Abstract
Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm that is usually located in the extremities and retroperitoneum. In the past, UPS was considered the most common soft tissue sarcoma in adults; due to improvements in diagnostic techniques, most cases have been reclassified as other lineage-specific tumors. Gnathic bones are rarely affected, and the clinicopathological characteristics of this neoplasm when diagnosed in the jaw remain to be better described. In this report, we present a rare case of mandibular UPS affecting an 88-year-old female who demonstrated a painful swelling on the right side of the mandible that was accompanied by a pathological fracture. Microscopic examination revealed a pleomorphic spindle-cell neoplasm with mitotic figures and necrosis. The patient underwent surgery and adjuvant radiotherapy but experienced metastasis after 12 months of follow-up and died. Diagnosis of UPS is challenging, and oral pathologists must be aware of this entity when dealing with aggressive undifferenti-ated neoplasms.
- keywords
- Soft tissue sarcoma, Pleomorphic sarcoma, Malignant fibrous histiocytoma, Oral cavity, Mandible
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