ISSN : 0376-4672
Maxillary sinus squamous cell carcinoma is a relatively rare disease, comprising only 3% of malignant diseases of head and neck. As the growth rate is high and its prognosis is poor compared to others, the 5-year survival rate of maxillary sinus squamous cell carcinoma(MSSCC) is 23.4-49%. We introduce two rare clinical cases of squamous cell carcinoma originated from maxillary sinus of which symptoms include toothache and gingival swelling. On clinical examinations of both patients, deep periodontal pockets on upper right posterior teeth were detected. On panoramic images, the bony destruction of the maxillary sinus and its surrounding structures were not obvious and only alveolar bone loss was noted. It is difficult to diagnose MSSCC at an early stage due to symptoms of tooth pain and gingival swelling that are similar to that of periodontal diseases. However, if the symptoms do not improve after routine treatment of upper teeth, dentists should bear in mind of underlying malignant mass as differential diagnosis, thus early detection of the lethal disease. The aim of this study is to caution dental practitioners that malignancies have a potential to mimic periodontal diseases by introducing two cases of maxillary sinus squamous cell carcinoma presented as periodontitis.
1. Al-Jhani AS, Al-Rajhi NM, El-Sebaie MM, et al. Maxillary sinus carcinoma - Natural history and outcome. Saudi Medl J 2004; 25(7):929-933 Saudi Med J.
2. Santos MR, Servato JP, Cardoso SV, et al. Squamous cell carcinoma at maxillary sinus:clinicopathologic data in a single Brazilian institution with review of literature. Int J Clin Exp Pathol 2014; 7(12):8823-8832.
3. Wang JH, Lee JH, Han JH, et al. Contralateral maxillary sinus lesions in patients with nasal cavity and/or paranasal sinus carcinoma: analysis of computed tomography findings. Ann Otol Rhinol Laryngol 2008; 117(12):909-913.
4. Turner JH, Reh DD. Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck 2012; 34(6):877-885.
5. Tiwari R, Hardillo JA, Mehta D, et al. Squamous cell carcinoma of maxillary sinus. Head Neck 2000; 22(2):164-169.
6. Paulino AC, Marks JE, Bricker P, et al. Results of treatment of patients with maxillary sinus carcinoma. Cancer 1998; 83(3):457-465.
7. Bhattacharyya N. Factors affecting survival in maxillary sinus cancer. J Oral Maxillofac Surg 2003; 61(9):1016-1021.
8. Kreppel M, Safi AF, Scheer M, et al. The importance of early diagnosis in patients with maxillary sinus carcinoma. Eur Arch Otorhinolaryngol 2016; 273(9):2629-2635.
9. Bobinskas AM, Wiesenfeld D, Chandu A. Influence of the site of origin on the outcome of squamous cell carcinoma of the maxilla-oral versus sinus. Int J Oral Maxillofac Surg 2014; 43(2):137-141.
10. Dubal PM, Bhojwani A, Patel TD, et al. Squamous cell carcinoma of the maxillary sinus: A populationbased analysis. Laryngoscope 2016; 126(2):399-404.
11. Stern SJ, Goepfert H, Clayman G, et al. Squamous-cell carcinoma of the maxillary sinus. Archives of Otolaryngology-Head & Neck Surgery 1993; 119(9):964-969.
12. Kaneko T, Tada Y, Maruya S, et al. Intra-arterial chemoradiation therapy with weekly low-dose cisplatin for squamous cell carcinoma of the maxillary sinus. Int J Oral Maxillofac Surg 2015; 44(6):697-704.
13. Linz C, Muller-Richter UD, Buck AK, et al. Performance of cone beam computed tomography in comparison to conventional imaging techniques for the detection of bone invasion in oral cancer. Int J Oral Maxillofac Surg 2015; 44(1):8-15.
14. Gao W, Guo CB. Factors Related to Delay in Diagnosis of Oral Squamous Cell Carcinoma. J Oral Maxillofac Surg. 2009; 67(5):1015-1020.
15. Carrau RL, Myers EM, Johnson JT. Paranasal sinus carcinoma--diagnosis, treatment, and prognosis. Oncology (Williston Park) 1992; 6(1):43-50; discussion 55-46.
16. Edwards PC, Hess SJ, Saini T. Sinonasal undifferentiated carcinoma of the maxillary sinus. J Can Dent Assoc 2006; 72(2):163-167.
17. White SC, Pharoah MJ. The evolution and application of dental maxillofacial imaging modalities. Dent Clin North Am 2008; 52(4):689-705, v.
18. Shahbazian M, Vandewoude C, Wyatt J, Jacobs R. Comparative assessment of panoramic radiography and CBCT imaging for radiodiagnostics in the posterior maxilla. Clin Oral Investig 2014; 18(1):293-300.
