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Oral appliances are the main alternative to continuous positive airway pressure (CPAP) for the treatment of obstructive sleep apnea(OSA). Treatment of OSA with oral appliance (OA) could provide an equivalent health benefit to achieve the best possible health outcomes. But not all outcome of OA treatment is successful. The challenge of predicting which patients will not receive therapeutic benefit from OA remains a barrier to the more widespread use of this therapy. This review summarizes some of the putative action mechanisms related to oral appliance effectiveness, side effects and its management, and on patient acceptability and treatment adherence are discussed.
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