ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
사전등록 바로가기
 

논문 상세

Home > 논문 상세
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

다음

27권 4호
Share

The Effcts of Dohongsamul-tang on Cytokine Production in Peripheral Blood Monocular Cells of Patients with Acute Cerebral Infarction

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.4, pp.1-11
박세욱 (원광대학교)
강백규 (원광대학교)
이인 (부산대학교)
조광호 (원광대학교)
문병순 (원광대학교)
이선우 (원광대학교)
박세욱, 강백규, 이인, 조광호, 문병순, & 이선우. (2006). . 대한한의학회지, 27(4), 1-11.
  • 다운로드 수
  • 조회수

Abstract

Objectives：We investigated the effect of Dohongsamul-tang (DHSMT) on the production of various cytokines in lipopolysaccaride (LPS) stimulated peripheral mononuclear cells (PBMCs) from CI patients. Methods: Cell viability was determined using MTT assay. ELISA was carried out for investigating TNF-α, IL-1β, IL-6, IL-8, IL-4, and TGF-β1 Results：The amount of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, IL-4, and transforming growth factor (TGF)-β1 in PBMC culture supernatant significantly increased in the LPS treated cells compared to unstimulated cells. We show that DHSMT inhibited the production of TNF-α, IL-1β IL-6, IL-8, and IL-4 induced by LPS in a dose dependent manner. The maximal inhibition rate of the TNF-α, IL-1β, IL-6, IL-8, and IL-4 production by pretreatment of DHSMT (1.0 mg/ml) was 38.52 ± 2.5% (P < 0.01), 44.02 ± 3.5% (P < 0.05), 45.32 ± 2.3% (P < 0.01), 42.30 ± 3.1% (P < 0.05), and 49.70 ± 3.1% (P < 0.05), respectively. On the other hand, DHSMT significantly increased the LPS-induced TGF-β1 production (P <0.05). Conclusions：Taken together, these results suggest that DHSMT might have regulatory effects on cytokine production, which might explain its beneficial effect in the treatment of CI.

keywords


  • 다운로드 수
  • 조회수
  • 0KCI 피인용수
  • 0WOS 피인용수

권호 내 다른 논문

추천 논문

상단으로 이동

권호 목록

소개

규정 및 지침

게시판

대한한의학회지

  학술지 홈페이지 이용 환경은   크롬 브라우저 사용을 권장합니다.

대한한의학회지

논문 투고 OA 정책