- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effects of Saenghyul-dan(SHD)on the Myelosuppression Induced by 5-Fluorouracil
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.4, pp.66-77
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(2006). Effects of Saenghyul-dan(SHD)on the Myelosuppression Induced by 5-Fluorouracil. Journal of Korean Medicine, 27(4), 66-77.
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Abstract
Objective：This study aimed to investigate the effects of SHD on myelosuppression using an animal model for therapeutic evidence supporting clinical positive results. Methods：After determining the optimal concentration of 5-FU as 300 ㎎/㎏ for developing the mouse model, ICR mice or BALB/c mice were administered with SHD, and several blood parameters, including hematopoietic cytokines, colony forming activity and histological findings, were examined to evaluate the effects. Results：SHD restored the WBC and hemoglobin, and showed effects on maintaining body weight, producing GM-CSF and IL-3 and stem cell colony forming activity in accordance with histological relative entirety on bone marrow. Conclusion：SHD is an herbal drug having therapeutic effects on myelosuppression. Thus, it could be prescribed to cancer patients undergoing chemo-therapies or radio-therapies in the process of cancer treatment.
- keywords
- Saenghyul-dan (shēngxiědān), myelosuppression, Saenghyul-dan (shēngxiědān), myelosuppression
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