- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Log In/Sign Up
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Anti-proliferative Effect of Coptis Chinensis Extrac in Hep G2 Cells
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.4, pp.50-60
&
(2006). Anti-proliferative Effect of Coptis Chinensis Extrac in Hep G2 Cells. Journal of Korean Medicine, 27(4), 50-60.
- Downloaded
- Viewed
Abstract
Objectives：This study is aimed to elucidate anti-hepatoma activity of Coptis Chinensis Extract (CCE) and evaluate its effect on proliferation of human hepatoma Hep G2 cells. Methods：To identify CCE and control the quality, we performed fingerprinting by high-performance thin layer chromatography (HPTLC).To investigate effects of CCE on anti-hepatoma activity, we measured cytotoxicity against Hep G2 cells compared with treatment of paclitaxel and 5-fluorouracil (5-FU).To examine the mechanism of inhibitory effect of CCE on Hep G2 cell proliferation, cell cycle distribution was evaluated using fluorescent activated cell sorter (FACS) Results：CCE showed a significant effect that arrests Hep G2 cells at the G2/M phase of the cell cycle. CCE combined with paclitaxel inhibited synergistically cell growth of Hep G2 cells. Conclusion：CCE may present anticancer effects through inhibition of hepatocellular carcinoma (HCC) cell proliferation via G2/M arrest, and may be a useful anticancer agent for HCC.
- keywords
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- The Effcts of Dohongsamul-tang on Cytokine Production in Peripheral Blood Monocular Cells of Patients with Acute Cerebral Infarction
- Effects of Cordyceps Militaris Extract on Tumor Immunity
- Effects of Cirsium japonicumvar,ussuriense Extract on Tumor Immunity
- Anti-proliferative Effect of Coptis Chinensis Extrac in Hep G2 Cells
- The Clinical Effect of Manipulation of Acupuncture to Shen-men and Nei-kwan on Blood Pressure of Normal Subjects
- Effects of Saenghyul-dan(SHD)on the Myelosuppression Induced by 5-Fluorouracil
- Smooth Muscle Relaxation by an HerbalMedicine ssangwhatang associated with Nitric Oxide Synthase Activation and Nitric Oxide production
- Effects of costunolide derived from Saussurea lappa Clarke on the apoptosis in AGS Stomach Cancer Cell Lines
- Antihyperlipidemic and AntioxidantEffects of Insamsansa-eum(Renshenshanzha-yin) in Hypercholesterolemic Rats
- Fucoidan Extract from Laminaria religiosa Suppresses Ischemia-induced Apoptosis and Cell Proliferation in the Hippocampus of Gerbis
- Effects of Herbal Bath on Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region of Brain after Sciatic Crushed Nerve Injury in Rats
- Effects of Prenatal Cnidium officinale Makino Treatment on Spatial Memory and Neurogenesis in the Hippocampus of Rat Pups Born from the Maternal Rats Exposed to Noise stress during Pregnancy
- Clinical Assessment of Usefulness,Effectiveness and Safety of Kyejibokryung-hwan on Various Neuropathies
- The correlation between Deviation Indexes of Ryodaraku and Acute Stress in Patients with Functional Dyspepsia
- Quality Monitoring of Distributed Schizandra chinensis (Turcz.) Bail in Korea
- Effects of warming Acupuncture on ligament Recovery Following Injury
- Inhibitory effect of the Scutellaria barbata Don water-extracts on the growth and DNA incorporation of human cancer cells
- Effects of Herbal Acupunctureof Clematis Mandshurica Maxim by Sinsu-hyul (BL 23) on Adjuvant Arthritis in Rats.
- Mechanism of Herbal Acupuncture of Clematis Mandshurica Maxim. Water Extractby Stimulation of Sinsu loci Subcutaneouslyas Dual Inhibitor of Proinflammatory Cytokines on Adjuvant Arthritis in Rats.
- Anti-depressant Effect of Chilbokum Under The Forced Swimming Test in Rats
- Clinical Effects of Korean Ginseng, Korean Red Ginseng, Chinese Ginseng, and American Ginseng on Blood Pressure in Mild Hypertensive Subjects
- A Clinical Observation of Serocoversion on Chronic Hepatitis B treated with a Herbs- Prescreiption
- The Clinical Study on the Factors Related with the Sequelae of Facial Palsy
- A Randomized, Single-Blind, 2-Limbed, Parallel-Group Study to Compare the Effectiveness of ‘Individualized Traditional Korean Acupuncture’ with one of ‘Standardized Minimal Acupuncture’
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.