- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effects of Herbal Acupunctureof Clematis Mandshurica Maxim by Sinsu-hyul (BL 23) on Adjuvant Arthritis in Rats.
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.4, pp.177-185
&
(2006). Effects of Herbal Acupunctureof Clematis Mandshurica Maxim by Sinsu-hyul (BL 23) on Adjuvant Arthritis in Rats.. Journal of Korean Medicine, 27(4), 177-185.
- Downloaded
- Viewed
Abstract
Objective : Based on the immunological dysfunction in RA and the immunological feature of Clematis mandshurica Maxim. herbal acupuncture solution (CM-HAS), this study examined whether subcutaneous (s.c.) administration of CM-HAS has anti-inflammatory effects on adjuvant arthritis (AA) in the rat. Methods : Complete Freund's adjuvant was used to induce AA in rats. Secondary paw swelling of AA rats was measured, and polyarthritis index was scored. The administration of CM-HAS (2, 5, 10 mg/kg) to the Sinsu-hyul (BL 23) acupuncture point subcutaneously (s.c.) inhibited the inflammatory response and restored the weight of body and immune organs of AA rats. In this study, inhibitory effect of CM-HAS on cyclooxygenase-2 (COX-2) was evaluated. The plant material selected for this study has been used in Korean medicine for the treatment of various diseases that are considered as inflammatory in nature, e.g. asthma, arthritis, rheumatism, fever, edema, infections, snakebite and related inflammatory diseases. Results : There were significant secondary inflammatory reactions in AA rats, accompanied with the simultaneous decrease of body and immune organs weight. The administration of CM-HAS (2, 5, 10 mg/kg, s.c.) improved the above changes significantly. CM-HAS showed inhibitory activity against COX-2, which supports their traditional uses. In this study, aspirin and indomethacin were used to contrast with CM-HAS as the COX-2 inhibitors. Conclusion: The findings of this study may explain at least in part why CM-HAS has been traditionally used for the treatment of inflammatory conditions in traditional Korean and Chinese medicine.
- keywords
- herbal acupuncture, Clematis mandshurica Maxim., Sinsu-hyul (BL 23)
Reference
1
(1996) Subacute toxicity of SKI306X,
2
(1999) Esculetin (dihydroxycoumarin) inhibits the production of matrix metalloproteinases in cartilage explants, and oral administration of its prodrug,
3
(1995) Preparation of antiinflammatory herbal drug,
4
(2001) Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee,
5
(2002) Effects of SKI 306X, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model,
6
(1995) Structureactivity studies of natural products with anti-inflammatory effects. In: Hostettmann, Clarendon Press
7
(1997) Inhibitory effects of Turkish folk remedies on inflammatory cytokines: interleukin-1,
8
(1983) Protective effects of prostaglandins against gastric mucosal damage American Journal of Physiology 1983,
9
(1998) Cyclooxygenase-1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity,
10
(1987) Inflammation and the mechanism of action of anti-inflammatory drugs,
11
(2004) Protective andanti-arthritic effects of deer antler aqua-acupuncture,
12
(2002) Inhibotory effect of a Korean traditional medicine water extracts of Carthamus tinctorius L,
13
(2002) TK Lee and CH Lee Inhibitory effect of Carthamus tinctorius L seed extracts on bone resorption mediated by tyrosine kinase,
14
(2005) Suppressive effects of a water extract of Ulmus davidiana Planch on collagen-induced arthritis in mice,
15
(1974) A simple radiochemical assay for prostaglandin synthetase,
16
(1998) Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis Journal of Natural Products 1998,
17
(1999) Animal models of arthritis relevance to human disease,
18
(1959) Some new records of medicinal plants used by the aborigines of tropical Queensland and New Guinea Proceedings of the Royal Society of Queensland,
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- The Effcts of Dohongsamul-tang on Cytokine Production in Peripheral Blood Monocular Cells of Patients with Acute Cerebral Infarction
- Effects of Cordyceps Militaris Extract on Tumor Immunity
- Effects of Cirsium japonicumvar,ussuriense Extract on Tumor Immunity
- Anti-proliferative Effect of Coptis Chinensis Extrac in Hep G2 Cells
- The Clinical Effect of Manipulation of Acupuncture to Shen-men and Nei-kwan on Blood Pressure of Normal Subjects
- Effects of Saenghyul-dan(SHD)on the Myelosuppression Induced by 5-Fluorouracil
- Smooth Muscle Relaxation by an HerbalMedicine ssangwhatang associated with Nitric Oxide Synthase Activation and Nitric Oxide production
- Effects of costunolide derived from Saussurea lappa Clarke on the apoptosis in AGS Stomach Cancer Cell Lines
- Antihyperlipidemic and AntioxidantEffects of Insamsansa-eum(Renshenshanzha-yin) in Hypercholesterolemic Rats
- Fucoidan Extract from Laminaria religiosa Suppresses Ischemia-induced Apoptosis and Cell Proliferation in the Hippocampus of Gerbis
- Effects of Herbal Bath on Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region of Brain after Sciatic Crushed Nerve Injury in Rats
- Effects of Prenatal Cnidium officinale Makino Treatment on Spatial Memory and Neurogenesis in the Hippocampus of Rat Pups Born from the Maternal Rats Exposed to Noise stress during Pregnancy
- Clinical Assessment of Usefulness,Effectiveness and Safety of Kyejibokryung-hwan on Various Neuropathies
- The correlation between Deviation Indexes of Ryodaraku and Acute Stress in Patients with Functional Dyspepsia
- Quality Monitoring of Distributed Schizandra chinensis (Turcz.) Bail in Korea
- Effects of warming Acupuncture on ligament Recovery Following Injury
- Inhibitory effect of the Scutellaria barbata Don water-extracts on the growth and DNA incorporation of human cancer cells
- Effects of Herbal Acupunctureof Clematis Mandshurica Maxim by Sinsu-hyul (BL 23) on Adjuvant Arthritis in Rats.
- Mechanism of Herbal Acupuncture of Clematis Mandshurica Maxim. Water Extractby Stimulation of Sinsu loci Subcutaneouslyas Dual Inhibitor of Proinflammatory Cytokines on Adjuvant Arthritis in Rats.
- Anti-depressant Effect of Chilbokum Under The Forced Swimming Test in Rats
- Clinical Effects of Korean Ginseng, Korean Red Ginseng, Chinese Ginseng, and American Ginseng on Blood Pressure in Mild Hypertensive Subjects
- A Clinical Observation of Serocoversion on Chronic Hepatitis B treated with a Herbs- Prescreiption
- The Clinical Study on the Factors Related with the Sequelae of Facial Palsy
- A Randomized, Single-Blind, 2-Limbed, Parallel-Group Study to Compare the Effectiveness of ‘Individualized Traditional Korean Acupuncture’ with one of ‘Standardized Minimal Acupuncture’
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.