- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Effcts of Dohongsamul-tang on Cytokine Production in Peripheral Blood Monocular Cells of Patients with Acute Cerebral Infarction
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.4, pp.1-11
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(2006). The Effcts of Dohongsamul-tang on Cytokine Production in Peripheral Blood Monocular Cells of Patients with Acute Cerebral Infarction. Journal of Korean Medicine, 27(4), 1-11.
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Abstract
Objectives：We investigated the effect of Dohongsamul-tang (DHSMT) on the production of various cytokines in lipopolysaccaride (LPS) stimulated peripheral mononuclear cells (PBMCs) from CI patients. Methods: Cell viability was determined using MTT assay. ELISA was carried out for investigating TNF-α, IL-1β, IL-6, IL-8, IL-4, and TGF-β1 Results：The amount of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, IL-4, and transforming growth factor (TGF)-β1 in PBMC culture supernatant significantly increased in the LPS treated cells compared to unstimulated cells. We show that DHSMT inhibited the production of TNF-α, IL-1β IL-6, IL-8, and IL-4 induced by LPS in a dose dependent manner. The maximal inhibition rate of the TNF-α, IL-1β, IL-6, IL-8, and IL-4 production by pretreatment of DHSMT (1.0 mg/ml) was 38.52 ± 2.5% (P < 0.01), 44.02 ± 3.5% (P < 0.05), 45.32 ± 2.3% (P < 0.01), 42.30 ± 3.1% (P < 0.05), and 49.70 ± 3.1% (P < 0.05), respectively. On the other hand, DHSMT significantly increased the LPS-induced TGF-β1 production (P <0.05). Conclusions：Taken together, these results suggest that DHSMT might have regulatory effects on cytokine production, which might explain its beneficial effect in the treatment of CI.
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