- P-ISSN 1010-0695
- E-ISSN 2288-3339
- 권한신청
- P-ISSN1010-0695
- E-ISSN2288-3339
논문 상세
Home > 논문 상세
Effects of costunolide derived from Saussurea lappa Clarke on the apoptosis in AGS Stomach Cancer Cell Lines
대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.4, pp.88-99
(경희대학교)
(경희대학교)
(경희대학교)
선승호,
&
고승규.
(2006). . 대한한의학회지, 27(4), 88-99.
- 다운로드 수
- 조회수
Abstract
Costunolide is an active sesquiterpene lactone isolated from the root of Saussurea lappa Clarke and is known to exhibit a variety of biological activities, including anti-carcinogenic and anti-inflammatory effects. Nevertheless, the pharmacological pathways of costunolide have not yet been fully elucidated. In this study, its cytotoxic effects were examined using AGS gastric cancer cells. Its treatment resulted in apoptosis in a dose- and time-dependent manner. The effects were attributed to the regulation of pro-apoptotic molecules and suppression of anti-apoptotic molecules. These results suggest that costunolide may be a candidate to deal with gastric cancers by chemopreventive agents.
- keywords
- Costunolide, apoptosis, cell proliferation, Costunolide, apoptosis, cell proliferation
- 다운로드 수
- 조회수
- 0KCI 피인용수
- 0WOS 피인용수
권호 내 다른 논문
- The Effcts of Dohongsamul-tang on Cytokine Production in Peripheral Blood Monocular Cells of Patients with Acute Cerebral Infarction
- Effects of Cordyceps Militaris Extract on Tumor Immunity
- Effects of Cirsium japonicumvar,ussuriense Extract on Tumor Immunity
- Anti-proliferative Effect of Coptis Chinensis Extrac in Hep G2 Cells
- The Clinical Effect of Manipulation of Acupuncture to Shen-men and Nei-kwan on Blood Pressure of Normal Subjects
- Effects of Saenghyul-dan(SHD)on the Myelosuppression Induced by 5-Fluorouracil
- Smooth Muscle Relaxation by an HerbalMedicine ssangwhatang associated with Nitric Oxide Synthase Activation and Nitric Oxide production
- Effects of costunolide derived from Saussurea lappa Clarke on the apoptosis in AGS Stomach Cancer Cell Lines
- Antihyperlipidemic and AntioxidantEffects of Insamsansa-eum(Renshenshanzha-yin) in Hypercholesterolemic Rats
- Fucoidan Extract from Laminaria religiosa Suppresses Ischemia-induced Apoptosis and Cell Proliferation in the Hippocampus of Gerbis
- Effects of Herbal Bath on Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region of Brain after Sciatic Crushed Nerve Injury in Rats
- Effects of Prenatal Cnidium officinale Makino Treatment on Spatial Memory and Neurogenesis in the Hippocampus of Rat Pups Born from the Maternal Rats Exposed to Noise stress during Pregnancy
- Clinical Assessment of Usefulness,Effectiveness and Safety of Kyejibokryung-hwan on Various Neuropathies
- The correlation between Deviation Indexes of Ryodaraku and Acute Stress in Patients with Functional Dyspepsia
- Quality Monitoring of Distributed Schizandra chinensis (Turcz.) Bail in Korea
- Effects of warming Acupuncture on ligament Recovery Following Injury
- Inhibitory effect of the Scutellaria barbata Don water-extracts on the growth and DNA incorporation of human cancer cells
- Effects of Herbal Acupunctureof Clematis Mandshurica Maxim by Sinsu-hyul (BL 23) on Adjuvant Arthritis in Rats.
- Mechanism of Herbal Acupuncture of Clematis Mandshurica Maxim. Water Extractby Stimulation of Sinsu loci Subcutaneouslyas Dual Inhibitor of Proinflammatory Cytokines on Adjuvant Arthritis in Rats.
- Anti-depressant Effect of Chilbokum Under The Forced Swimming Test in Rats
- Clinical Effects of Korean Ginseng, Korean Red Ginseng, Chinese Ginseng, and American Ginseng on Blood Pressure in Mild Hypertensive Subjects
- A Clinical Observation of Serocoversion on Chronic Hepatitis B treated with a Herbs- Prescreiption
- The Clinical Study on the Factors Related with the Sequelae of Facial Palsy
- A Randomized, Single-Blind, 2-Limbed, Parallel-Group Study to Compare the Effectiveness of ‘Individualized Traditional Korean Acupuncture’ with one of ‘Standardized Minimal Acupuncture’
- more
추천 논문
학술지 홈페이지 이용 환경은 크롬 브라우저 사용을 권장합니다.