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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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구원심신환이 methotrexate로 유발된 흰쥐의 면역기능저하에 미치는 영향

The effect of Kuwonsimsin-hwan on Imunosuppression Induced by Methotrexate in Rat

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.2, pp.126-136
최순호 (대구한의대학교)
강석봉 (대구한의대학교)
최선미 (한국한의학연구원)
이연경 (대구한의대학교)
최순호, 강석봉, 최선미, & 이연경. (2007). 구원심신환이 methotrexate로 유발된 흰쥐의 면역기능저하에 미치는 영향. 대한한의학회지, 28(2), 126-136.
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Abstract

Objectives : In the present study, the effect of Kuwonsimsin-hwan (KSS) was tested in methotrexate (MTX)-induced immunosuppressed SD rats. Methods : Methotrexate was fed to white rats once a day for 4 days. After the immune responses of the rats deteriorated, dried extracts of Kuwonsimsin-hwan mixed in water was fed to the rats once a day for 14 days. We then measured the number of lymphocytes in peripheral blood and the percentage of B-cells, T-cells, CD3+CD4+ T-cells, CD3+CD8+ T-cells and IL-2 productivity sampled from spleen and peripheral region. Results : ① The number of lymphocytes and the percentage of T-cells and CD3+CD4+ T-cellsin peripheral blood increased significantly in the KSS group as compared with the control group. ② The percentage of B-cells, CD3+CD8+ T-cells, and CD4+/CD8+ T-cells in peripheral blood were not different statistically. ③ The percentage of T-cells in spleen and IL-2 productivity of spleen cells increased significantly in the KSS group as compared with the control group. ④ The percentage of CD3+CD4+ T-cells in spleen increased in KSS the group as compared with the control group but without statistical significance. ⑤ The percentage of B-cells, CD3+CD8+ T-cells, and CD4+/CD8+ T-cells in spleen were not different statistically. Conclusion:It is concluded that Kuwonsimsin-hwan has immunostimulating effect on MTX-induced immunosuppressed SD rats.

keywords
Kuwonsimsin-hwan, methotrexate, immunosuppression, immunostimulation, Kuwonsimsin-hwan, methotrexate, immunosuppression, immunostimulation


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