- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Acute Toxicity Study on Sagunja-tang(Sijunzi-tang) in ICR Mice
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.2, pp.200-204
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(2007). Acute Toxicity Study on Sagunja-tang(Sijunzi-tang) in ICR Mice. Journal of Korean Medicine, 28(2), 200-204.
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Abstract
Objectives : The purpose of this study was to investigate acute toxicity of orally-treated Sagunja-tang(Sijunzi-tang) in ICR mice. Methods : In this study, we investigated the acute toxicity of water-extracted Sagunja-tang(Sijunzi-tang). Twenty-five mice completed 14 days of oral Sagunja-tang(Sijunzi-tang) at respective doses of 0 (control group), 2560, 3200, 4000 and 5000 ㎎/kg. Results : We observed survival rates, clinical signs of male ICR mice with acute toxicity, change of body weight and autopsy. Conclusions : Compared with the control group, we could not find any toxic alteration in anytreated groups (2560, 3200, 4000 and 5000㎎/kg). LD50 of Sagunja-tang(Sijunzi-tang) was over 5000 ㎎/kg and it is very safe for ICR mice.
- keywords
- Sagunja-tang(Sijunzi-tang), acute toxicity, safety, LD50, Sagunja-tang(Sijunzi-tang), acute toxicity, safety, LD50
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