- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Neuroprotective Effect of Hyulbuchookau-tang on Global Cerebral Ischemia of the Rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.2, pp.44-53
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(2007). Neuroprotective Effect of Hyulbuchookau-tang on Global Cerebral Ischemia of the Rats. Journal of Korean Medicine, 28(2), 44-53.
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Abstract
Objectives : This study examined the neuroprotective effect of Hyulbuchookau-tang (血府逐瘀湯, HBCAT) against neural damage following global cerebral infarction. Methods : Sprague-Dawley rats were induced with global cerebral infarction by occlusion of the bilateral common carotid artery with hypotension (CCAO). The rats were divided into 3 groups. We treated extract of HBCAT to one group after operation (sample group), one group wasn't induced with ischemic damage after operation (sham group), and one group was induced with ischemic damage after operation (control group) but not treated. We observed neurological scores and cresyl violet-stained hippocampus CA1 area, TUNEL-positive neurons, and Bax-positive neurons in brain regions. Results : HBCAT treatment after CCAO increased pyramidal neurons in CA1 hippocampus induced by CCAO. HBCAT treatment after CCAO reduced Bax-positive neurons in CA1 hippocampus of brain regions induced by CCAO. HBCAT treatment after CCAO wasn't effective for HSP70-positive neurons in CA1 hippocampus induced by CCAO. Conclusions : These results suggest that HBCAT has a neuroprotective effect against global cerebral ischemia.
- keywords
- : Hyulbuchookau-tang (血府逐瘀湯, HBCAT), common carotid artery occlusion (CCAO), neuroprotective effect, global cerebral infarction, : Hyulbuchookau-tang (血府逐瘀湯, HBCAT), common carotid artery occlusion (CCAO), neuroprotective effect, global cerebral infarction
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