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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

The Effects of Jiyutang against Gastric and Ileac Mucosal Ulcer Induced by Indomethacin in Mouse

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.2, pp.224-240





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Abstract

Objectives : This study was carried out to investigate the effects of Jiyu-tang on gastric and ileac mucosal ulcer induced by indomethacin in mouse.. Methods : The normal group was that no inflammation elicited mouse. Control group is that water administered mouse after gastro-inflammation elicitation. Sample group is that Jiyu-tang administered mouse after gastro-inflammation elicitation. Results : In the common morphology and histochemical change, control group were observed various injury by hemorrhagic erosion, while sample group was noticeably decreased than control group. In the immunohistochemical change, the distributions of COX-1 treated with Jiyu-tang noticeably increased than control group(p<0.05). The distributions of COX-2, MAC 387 and HSP-70, PCNA and TUNEL treated with Jiyu-tang noticeably decreased than control group(p<0.05). Conclusions : According to the above results, it is supposed that Jiyu-tang is applicable to gastric and ileac mucosal ulcer.

keywords
Jiyu-tang, Gastric Ulcer, Ileac Ulcer, COX-1, COX-2, Jiyu-tang, Gastric Ulcer, Ileac Ulcer, COX-1, COX-2


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