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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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Alcohol, Indomethacin 및 Burn-stress로 유발된 생쥐의 위점막 손상에 대한 대금음자, 익위탕, 시호소간산의 효과

Effects of Daegeum-eumja, Igwi-tang Sihosogan-san on Gastric Mucosal Lesions Induced by Alcohol, Indomethacin and Burn-stress in Mice

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.2, pp.166-184
공경환 (세명대학교)
공경환. (2007). Alcohol, Indomethacin 및 Burn-stress로 유발된 생쥐의 위점막 손상에 대한 대금음자, 익위탕, 시호소간산의 효과. 대한한의학회지, 28(2), 166-184.
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Abstract

Objectives : This study was conducted to investigate the effects of Daegeum-eumja, Igwi-tang, and Sihosogan-san on gastric mucosal lesions induced by alcohol, indomethacin, and burn-stress in mice. Methods : Experimental mice were divided into six groups. The normal group (NOR) did not receive any treatment to elicit gastropathy. In the control group (GE), gastropathy was elicited by alcohol, indomethacin, and stress. In the misoprostol group (MS), misoprostol was administered after gastropathy was elicited by alcohol, indomethacin, and stress. In the Daegeum-eumja group (DG), Daegeum-eumja was administered after gastropathy was elicited by alcohol, indomethacin, and stress. In the Igwi-tang group (IW), Igwi-tang was administered after gastropathy was elicited by alcohol, indomethacin, and stress. In the Sihosogan-san group (SH), Sihosogan-san was administered after gastropathy waselicited by alcohol, indomethacin, and stress. The effects on gastric mucosal lesions were evaluated by the morphological change of gastric mucosa, the anti-oxidant effect, HSP 70, NF-κB p65, IκB, COX-1, PNA, BrdU, and iNOS. Results : Hemorrhage erosion, HSP70, and NF-κB in the DG, IW and SH groups decreased more than that of the control. The IκB, COX-1, PNA, BrdU, and iNOS in the DG, IW, and SH groups increased more than that of the control. DG showed the most effect against gastric mucosal lesions induced by alcohol; IW against gastric mucosal lesions induced by indomethacin; and SH against gastric mucosal lesions induced by burn-stress. Conclusions : Daegeum-eumja, Igwi-tang, and Sihosogan-san extracts have excellent effects on gastric mucosal lesions induced by alcohol, indomethacin, and burn-stress, respectively.

keywords
Sihosogan-san, Daegeum-eumja, Igwi-tang, gastric mucosal lesions, Sihosogan-san, Daegeum-eumja, Igwi-tang, gastric mucosal lesions


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