Damsam-san Inhibits Atherosclerosis through Regulation of Foam Cell Formation and Vascular Smooth Muscle Proliferation

유도균; 최동준; 한창호; 정승현; 신길조; 이원철; 강윤호

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P-ISSN 1010-0695
E-ISSN 2288-3339

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28권 2호

Damsam-san Inhibits Atherosclerosis through Regulation of Foam Cell Formation and Vascular Smooth Muscle Proliferation

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339

2007, v.28 no.2, pp.185-199

유도균 (동국대학교 한의과대학)
최동준 (동국대학교 한의과대학)
한창호 (동국대학교 한의과대학)
정승현 (동국대학교 한의과대학)
신길조 (동국대학교)
이원철 (동국대학교 한의과대학)
강윤호 (동국대학교 한의과대학)

유도균, 최동준, 한창호, 정승현, 신길조, 이원철, & 강윤호. (2007). 단삼산의 거품세포 형성 및 혈관평활근세포 증식 억제를 통한 항동맥경화 효과. 대한한의학회지, 28(2), 185-199.

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Abstract

Objectives : This study was carried out to investigate the inhibitive effect of a combined-herb prescription of Dansam-san (DSS) on formation of foam cells and cytokine. Methods : Experimental formation of foam cells was induced on macrophage RAW 264.7 with ox-LDL. The effect of DSS extract was observed by measuring the changes of CD36, PPAR-г, MMP-9, iNOS expression and changes of formation level of foam cells after treating experimentally induced foam cells with DSS extract. Then the antioxidative effect of DSS extract was compared with butylated hydroxyanisole (BHA). Results and Conclusions : Results obtained are as follows: 1. DSS extract showed significant antioxidative effect at 8 ㎎/㎖ or more. 2. DSS extract inhibited the formation of foam cells. 3. DSS extract inhibited the creation and revelation of conversion-related material about foam cells. 4. DSS extract prohibited the increase of smooth muscle of vessels.

keywords: Dansam-san, foam cells, atherosclerosis, Dansam-san, foam cells, atherosclerosis

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논문 상세

단삼산의 거품세포 형성 및 혈관평활근세포 증식 억제를 통한 항동맥경화 효과

Damsam-san Inhibits Atherosclerosis through Regulation of Foam Cell Formation and Vascular Smooth Muscle Proliferation

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