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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Indomethacin으로 유발된 생쥐의 위와 회장 점막 염증에 미치는 지유탕의 효과

The Effects of Jiyutang against Gastric and Ileac Mucosal Ulcer Induced by Indomethacin in Mouse

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.2, pp.224-240
강아미 (동국대학교 한의과대학)
최은영 (동국대학교 한의과대학)
김학재 (동국대학교 한의과대학)
한이수 (동국대학교 한의과대학)
임성우 (경원대학교 한의과대학)
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Abstract

Objectives : This study was carried out to investigate the effects of Jiyu-tang on gastric and ileac mucosal ulcer induced by indomethacin in mouse.. Methods : The normal group was that no inflammation elicited mouse. Control group is that water administered mouse after gastro-inflammation elicitation. Sample group is that Jiyu-tang administered mouse after gastro-inflammation elicitation. Results : In the common morphology and histochemical change, control group were observed various injury by hemorrhagic erosion, while sample group was noticeably decreased than control group. In the immunohistochemical change, the distributions of COX-1 treated with Jiyu-tang noticeably increased than control group(p<0.05). The distributions of COX-2, MAC 387 and HSP-70, PCNA and TUNEL treated with Jiyu-tang noticeably decreased than control group(p<0.05). Conclusions : According to the above results, it is supposed that Jiyu-tang is applicable to gastric and ileac mucosal ulcer.

keywords
Jiyu-tang, Gastric Ulcer, Ileac Ulcer, COX-1, COX-2, Jiyu-tang, Gastric Ulcer, Ileac Ulcer, COX-1, COX-2


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