- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effect of Aralia Cordata Pharmacopuncture on Cartilage Protection and Apoptosis Inhibition In Vitro and in Collagenased-induced Arthritis Rabbit Model
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.4, pp.114-123
Yong-Hyeon,
B.
, &
Dong-Suk,
P.
(2007). Effect of Aralia Cordata Pharmacopuncture on Cartilage Protection and Apoptosis Inhibition In Vitro and in Collagenased-induced Arthritis Rabbit Model. Journal of Korean Medicine, 28(4), 114-123.
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Abstract
Osteoarthritis is characterized by cartilage degradation and chondrocytes death. Chondrocyte death is induced by the apotosis through special mechanisms including the activation of caspase-3. On the basis of this background, this study was designed to examine the cartilage protective and anti-apototic effects of Aralia Cordata in in vtro and in collagenase-induced arthritis rabbit model. To conduct in vitro study, chondrocytes culturedfrom rabbit knee joint were treated by 5 ng/ml IL-1a.For in vivo experiment, collagenase-induced arthritis (CIA) rabbit model was made via intraarticular injection with 0.25 ml of collagenase solution. Aralia cordata pharmacopuncture (ACP) was administrated on bilateral Dokbi acupoint (ST35) of rabbits at a dosage of 150 ㎍/kg once a day for 28 days after the initiation of the CIA induction. In the study by using CIA rabbit model in vivo, ACP showed the inhibition of cartilage degradation in histological analysis. Aralia cordata also showed anti-apoptotic effect both in vitro and in vivo study. In chondrocytes treated by IL-1a, Aralia cordata inhibited caspase-3 activity and enhanced the proliferation of IL-1a-induced dedifferentiated chondrocytes. ACP showed the inhibition effect on the caspase-3 expression and activity from CIA rabbit model. This study indicates that ACP inhibits the cartilage destruction and the chondrocyte apotosis through downregulation of caspase-3 activity. These data suggest that ACP has a beneficial effect on preventing articular cartilage destruction in osteoarthrtis.
- keywords
- Aralia cordata, osteoarthritis (OA), cartilage, apotosis, caspase-3, collagenase-induced arthritis (CIA), Aralia cordata, osteoarthritis (OA), cartilage, apotosis, caspase-3, collagenase-induced arthritis (CIA)
Reference
1
(2001) Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis,
2
(1999) An introduction to the pathoph- ysiology of osteoarthritis,
3
(1999) Degradation and repair of articular cartilage,
4
(1999) Degradative enzymes in osteoar- thritis,
5
(1999) Metabolic disturbances and synovial joint responses in osteoarthritis,
6
(1999) Developmental patterns of cartilage,
7
(2000) Cellular interactions and signaling in cartilage devel- opment,
8
(1995) Apoptosis in rheumatoid arthritis synovium,
9
(1983) Hypertrophic repair of articular cartilage in experimental osteoarthritis,
10
(1995) Discoordinate gene expression of aggr- ecan and type Ⅱ collagen in experimental osteoarthritis,
11
(1998) Osteoarthritic chondrocytes die by apoptosis: a possible pathway for osteoarthritis pathology,
12
(2000) Apoptotic chondrocyte death in human osteoarthritis,
13
(2001) Relationship between chondrocyte apoptosis and matrix depletion in human articular cartilage,
14
(2001) Prevention of chondro- cyte apoptosis,
15
(1998) MEKK1/JNK signaling stabilizes and activ- ates p53,
16
(2007) Cytokine activ- ation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3,
17
(2005) Inhibitory constituents against cyclooxygenases form Aralia cordata Thunb,
18
(1991) Analgesic principles from Aralia cordata Thunb,
19
(1975) Culture of chondrocytes from the proliferative zone of epiphyseal growth plate cartilage from prepubertal rabbits,
20
(197153) Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips,
21
(197153) Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips,
22
(2002) Effects of SKI 306X, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model,
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