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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

The Anti-obesity Effects of Gambi-hwan Extract on Obese Rats Induced by High-fat Diet through the Expression of UCP-1 and PPARδ

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.4, pp.136-147
Beom-Joon Lee
Jae-Hwan Ryu
Jae-Wan Kim
Jong-Hun Park
Jae-Woo Park
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Abstract

Objective : Recently there are a lot of attempts to treat obesity through energy expenditure. Especially UCP-1 and PPAR-δ is known to play a key role for energy dissipation through the increasing thermogenesis. Gambi-hwan extract is a traditional medicine made of herbs containing the polyunsaturate fatty acids related to the energy expenditure. It is expected to reduce the weight by means of the expression of UCP-1 and PPAR-δ. Meterial and Method : We divided 21 rats into 3 groups and assigned 8 rats respectively. The normal group was administered normal diet, the control group was administered high-fat diet, and the G50 group was administered high-fat diet with Gambi-hwan extracts50 mg/kg. And then the weights of body, food intake, the changes of lipids in blood stream, and the expressions of UCP-1 and PPAR-δ on adipose tissues were measured respectively. Result : The reduction of body weight and the increasing tendency of expression of UCP-1 and PPAR-δ mRNA were shown in G50 group. In the G50 group the Triglyceride level is decreased and the HDL-cholesterol level and the expression of PPAR-δ and UCP-1 protein on Visceral adipose tissue were significantly increased. Conclusion : This result indicates that Gambi-hwan Extract upregulate the expression of UCP-1 and PPAR-δ in adipose tissue, which may contribute to reducing the weight of adipose tissue.

keywords
Antiobesity, UCP, PPAR, Croton tiglium, buthus martensi karsch


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