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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Anti-metastatic and Immunomodulating Activity of Water-Soluble Components from Five Mushroom Extracts

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2009, v.30 no.3, pp.61-69






(R&D Lab. of Bulrolife Co., Ltd.)
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Abstract

Objectives:This experiment was conducted to evaluate the inhibitory effects against lung metastasis and promotion of splenocytes by water-soluble components from five mushrooms extracts (WEFM): Garnoderma frondosa, Corious versicolor, Codyceps militaris, Hericium erinaceus and Lentinula edodes. Methods:Colon 26-L5 carcinoma cells were injected through the tail vein to induce lung metastatic cancer. Changes in weight of lung were observed and cytokine level was analyzed to evaluate immunological changes. Results:Oral administration of WEFM resulted in a significant inhibition of lung metastasis after intravenous injection of colon 26-L5 cells in a dose-dependent manner. There was also a significant increase in T cell and B cell mitogenic stimuli and production of IFN-g by splenocytes stimulated with Con A compared to untreated controls. Conclusion:WEFM may have anti-tumor activities via Th1-type dominant immune responses.

keywords
colon 26-L5 cell, lung metastasis, IFN-γ, Th1 cytokine


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