- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Four-week Repeated Dose Toxicity Test for Myelophil in SD Rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2009, v.30 no.3, pp.79-85
(Safety Assessment Center)
(Safety Assessment Center)
&
(2009). Four-week Repeated Dose Toxicity Test for Myelophil in SD Rats. Journal of Korean Medicine, 30(3), 79-85.
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Abstract
Aim:To evaluate the pharmaceutical safety of the herbal formula Myelophil, composed of Astragali Radix and Salviae Radix, via systemic subacute toxicological study using SD rats. Methods:Forty male and 40 female SD rats were fed with Myelophil (5000, 2500 or 1250 mg/10 mL/kg) or distilled water for four weeks. Adverse effects were examined intensively by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, hematology, urinalysis, and blood biochemical analysis. Results:No altered clinical symptoms including body weight, diarrhea, anorexia, death, and abnormal necropsy of major organs were observed in male or female rats. No drug-induced abnormalities in histopathological finding, hematological values, urinalysis, and blood biochemical values were found at any doses of Myelophil. Conclusion:Myelophil should be very safe when used in a clinical application with a wide therapeutic index.
- keywords
- Myelophil, Astragali Radix, Salviae Radix, herbal remedy, safety, toxicological study
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