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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

자가 처방 감초 다량 복용 후 발생한 저칼륨성 하지마비 1례

A Case of Self-prescribed Licorice-induced Hypokalemic Paralysis

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.5, pp.134-138
권승원 (경희대학교)
정환용 (경희대학교)
윤승규 (경희대학교)
서유리 (경희대학교)
박준영 (경희대학교)
임진욱 (경희대학교)
정우상 (경희대학교)
문상관 (경희대학교)
조기호 (경희대학교)
김영석 (경희대학교)
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Abstract

Glycyrrhetinic acid, which is a component of licorice, can cause hypermineralocorticoidism through the inhibition of 11β-hydroxysteroid dehydrogenase. So, a high dose intake of licorice can lead to hypermineralocorticoidism with potassium loss and depression of the renin-angiotensin-aldosterone system. We report a 73-year-old man with muscle weakness of proximal lower limbs with hypokalemia (Serum K+: 1.4mEq/L) due to taking self-prescribed licorice without OMD's diagnosis. He boiled 60~100g licorice / day in water and drank it intermittently for 1 month due to arthralgia and swelling of both his knees. Patient's serum renin activity and aldosterone level were far beyond the normal range. He also had metabolic alkalosis with pH 7.552. After quitting the licorice, hypokalemia and muscle weakness of proximal lower limbs gradually improved within 1week.

keywords
Licorice, hypokalemic paralysis, glycyrrhetinic acid, self-prescription


참고문헌

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