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- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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A Case of Self-prescribed Licorice-induced Hypokalemic Paralysis
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.5, pp.134-138
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(2011). A Case of Self-prescribed Licorice-induced Hypokalemic Paralysis. Journal of Korean Medicine, 32(5), 134-138.
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Abstract
Glycyrrhetinic acid, which is a component of licorice, can cause hypermineralocorticoidism through the inhibition of 11β-hydroxysteroid dehydrogenase. So, a high dose intake of licorice can lead to hypermineralocorticoidism with potassium loss and depression of the renin-angiotensin-aldosterone system. We report a 73-year-old man with muscle weakness of proximal lower limbs with hypokalemia (Serum K＋: 1.4mEq/L) due to taking self-prescribed licorice without OMD's diagnosis. He boiled 60~100g licorice / day in water and drank it intermittently for 1 month due to arthralgia and swelling of both his knees. Patient's serum renin activity and aldosterone level were far beyond the normal range. He also had metabolic alkalosis with pH 7.552. After quitting the licorice, hypokalemia and muscle weakness of proximal lower limbs gradually improved within 1week.
- keywords
- Licorice, hypokalemic paralysis, glycyrrhetinic acid, self-prescription
Reference
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