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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Analysis of Biological Experiments on the Anti-inflammatory and Antipyretic Effects of Hwangryeonhaedok-tang

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2012, v.33 no.4, pp.26-36
Jung-Hoon Kim (Korea Institute of Oriental Medicine)
Hyeun Kyoo Shin (Korea Institute of Oriental Medicine)
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Abstract

Objectives: To establish scientific and objective evidence for the use of a Korean medicine, articles regarding Hwangryeonhaedok-tang (HRHDT), a herbal medicine frequently used in Korean medical clinics and hospitals, were gathered and analyzed. Methods: The articles were classified as being from domestic or international journals, and by their year of publication. The mechanisms of the anti-inflammatory and antipyretic effects of HRHDT were investigated. Results: Of the 25 articles analyzed, 7 were published from Korea, 7 were from China, and 11 were from Japan. HRHDT showed anti-inflammatory and antipyretic effects through the regulation of the expression of Th1 cytokines including interleukin-2 (IL-2), IL-8, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α); and Th2 cytokines including IL-4, IL-6, and IL-12, which inhibit leukotriene B4 (LTB4), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and inflammatory cells. It also lowered preprodynorphin (PPD), and corticotropin-releasing factor (CRF) in the peripheral nerve system and hypothalamus. Conclusions: We speculate that the anti-inflammatory and antipyretic effects could be related to the therapeutic efficacy of HRHDT in removing pathogenic fire and heat.

keywords
Hwangryeonhaedok-tang (HRHDT), evidence, anti-inflammatory, antipyretic, therapeutic efficacy


Reference

1

Yoshida H, Russell J, Senchenkova EY, Almeida Paula LD, Granger DN.  Mediates the Extra-Intestinal Thrombosis Associated with Experimental Colitis. Am J Pathol. 2010; 177(6):2774-2781.      

2

Hoyer KK, Dooms H, Barron L, Abbas AK. Interleukin-2 in the development and control of inflammatory disease. Immunol Rev. 2008; 226:19-28.     

3

Meier-Trummer CS, Rehrauer H, Franchini M, Patrignani A, Wagner U, Ackermann M. Malignant catarrhal fever of cattle is associated with low abundance of IL-2 transcript and a predominantly latent profile of ovine herpesvirus 2 gene expression. Plos one. 2009; 4(7):1-12.

4

Cardoso CR, Provinciatto PR, Godoi DF, Ferreira BR, Teixeira G, Rossi MA, et al. IL-4 regulates susceptibility to intestinal inflammation in murine food allergy. Am J Physiol Gastrointest Liver Physiol. 2009; 296:G593-G600.   

5

Sehra S, Bruns HA, Ahyi ANN, Nguyen ET, Schmidt NW, Michels EG, et al. IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6. J Immunol. 2008; 180:3551-3559.

6

Gabay C. Interleukin-6 and chronic inflammation. Arthritis Research & Therapy. 2006; 8(Suppl 2): 1-6.   

7

Pearl DS, Shah K, Whittaker M, Nitch-Smith H, Brown JF, Shute JK, et al. PMO-247 mucosal cytokine expression in ulcerative colitis: elevatedIL-8 but not  and reduced  in inflamed compared to non-inflamed mucosa. Gut. 2012; 61:A175.

8

Albert EJ, Marshall JS. Aging in the absence of TLR2 is associated with reduced  responses in the large intestine and increased severity of induced colitis. J Leukoc Biol. 2008; 83(4):833-842.      

9

Oshima T, Laroux FS, Coe LL, Morise Z, Kawachi S, Bauer P, et al. Interferon-gamma and interleukin- 10 reciprocally regulate endothelial junction integrity and barrier function. Microvasc Res. 2001; 61(3):291.      

10

Garside P. A role for IL-18 in intestinal inflammation? Gut. 2001: 6-7.

11

Herberth G, Heinrich J, Röder S, Figl A, Weiss M, Diez U, et al. Reduced - and enhanced IL-4-producing CD4+ cord blood T cells are associated with a higher risk for atopic dermatitis during the first 2 yr of life. Pediatr Allergy Immunol. 2010; 21(1-I):5-13.

12

Crisafulli C, Galuppo M, Cuzzocrea S. Effects of genetic and pharmacological inhibition of  in the regulation of inflammation in macrophages. Pharmacol Res. 2009; 60(4):332-340      

13

Bélanger C, Elimam H, Lefebvre J, Borgeat P, Marleau S. Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats. Immunology. 2008; 124(3):295-303.      

14

Kuang Z, Liu Q. Effect of Huanglian JieduDecoction on Serum Interleukin- 2 in Mice Attacked by D-galactosamine and Lipopolysaccharide. Journal of Guangzhou Universit y of Traditional Chinese Medicine. 1999; 16(3):221-222.

15

Zhao BS, Liu YG, Wang XL. The Experimental Study of Huanglianjiedu Decoction on Relieving Fever and Ant-i inflammatory Effects. Chinese Journal of Experimental Traditional Medical Formulae. 2009; 15(11):55-57.

16

Lu J, Wang JS, Kong LY. Anti-inflammatory effects of Huang-Lian-Jie-Du decoction, its two fractions and four typical compounds. J Ethnopharmacol. 2011; 134:911-918.      

17

Yang HJ, Joo HA, Baek SC, Park JS, Hong SH. Anti-inflammatory effects of Hwangnyeonhaedo k-tang and Fermented Hwangnyeonhaedok-tang. The Journal of Korean Oriental Medical Ophthal mology & Otolaryngology & Dermatology. 201 1; 24(2):1-15.

18

Kang YH, Kim JT, Kim SA. The effects of Hangryunhaedoktang on allergic contact dermatitis based on the morphological changes in epidermal damage in mice. Korean J Oriental Int Med. 2004; 25(3):508-517.

19

Gao XK, Fuseda K, Shibata T, Tanaka H, Inagaki N, Nagai H. Kampo medicines for mite antigen-induced allergic dermatitis in NC/Nga mice. eCAM. 2005; 2(2)191-199.

20

Kim BA, Kim MS, Kang BM, Byeon SH, Park IH, Park JH, et al. Inhibitory studies of Hwangryunhaedok-tang on development of atopic dermatitis in NC/Nga mice. Kor J Herbology. 2008; 23(2):59-65.

21

Kim BA, Yang JC, Park CI. Effect of Hwangryunhaedok-tang extracts on DNCBinduced allergic contact dermatitis. Kor J Herbology. 2009; 24(2):1-5.

22

Zhang G, Chi H. The Effect of antidotal decoction of Coptis on T-cell subpopulation and IL-2 activity of the rat with excess heat syndrome. Journal of Guangxi Traditional Chinese Medical University. 2002; 5(3):8-9.

23

Liu CF, Wang N, Liu S, Huang ZH, Zu JX, Li JH. Study of Huanglian Jiedu decoction on fever syndrome by metabonomics. Journal of Shandong university of TCM. 2011; 35(1):60-63.

24

The free dictionary. 2012;[1screen]. Available at: URL:http://www.thefreedictionary.com/inflammation. Accessed Sep 12, 2012.

25

Zhou H, Wang L, Feng X. The effect of Oren-gedoku-to on the TNB-induced colitis. J Trad Med. 1996; 13(4):376-377.

26

周海燕, 峰下哲. ラット実験大腸炎に対する黄連 解毒湯の影響 (第2報). The general meeting of Medical and Pharmaceutical Society for Wakan-yaku abstracts. 1997;14:94.

27

Iijima K, Hong T, Song QH, Cyong JC. Immunomodulatory action of Oren-gedoku-to on murine colitis model induced by TNBs. J Trad Med. 1998; 15(5):388-389.

28

洪鉄, 小林崇雄, 金光弼, 宋清華, 中島敏治, 平井浩一, 丁宗鐵. 大腸炎モデルマウスに対する黄連 解毒湯の影響. The general meeting of Medical and Pharmaceutical Society for Wakan-yaku abstracts. 1999; 16:77.

29

Zhou H, Mineshita S. The effect of Oren-gedoku-to on experimental colitis in rats. J Pharm Pharmacol. 1999; 51:1065-1074.   

30

Hong T, Jin GB, Kobayashi T, Song QH, Cyong JC. Effect of Oren-gedoku-to (Huang-Lian-Jie- Du-Tang) on the murine colitis induced by dextran sulfate sodium. J Trad Med. 2000; 17:66-72

31

Professor association of herbal formula of Korea medicine. Herbal formula. Seoul:Youngrimsa. 2003:180-81.

32

Western pacific region of world health organization. WHO international standard terminologies on traditional medicine in the western pacific region. World health organization. 2007:207.

33

An JH, Choi EY, Lee SH, Park IS, Lim SW. Effects of Hwangryunhaedok-tang on DSSinduced colitis. J Korean Oriental Med. 2006; 27(2):182-195.

34

Uao ZY, Jiang JL. The influence of HuangLianJieDu decoction on tissue injuries of experimental colitis in rat. Prac J Med & Pharm. 2006; 23(11):1349-1351.

35

遠藤真理, 及川哲郎, 羽鳥努, 花輪壽彦. デキスト ラン硫酸ナトリウム誘発大腸炎モデルに対する 黄連解毒湯の効果の検討. J Trad Med. 2007; 24(Supplement):95.

36

Lim DH. Effect of Hwangnyeonhaedoktang on experimental mouse colitis induced by dextran sulfate sodium[dissertation]. Iksan: Wonkwang Univ.; 2009.

37

Endo M, Oikawa T, Hoshino T, Hatori T, Matsumoto T, Hanawa T. Suppression of murine colitis by Kampo medicines, with special reference to the efficacy of saireito. J Trad Med. 2009; 26:110-121.

38

Kim KH, Kim SS. Study on analgesic, anti-inflammatory and antipyretic effects of aqua-acupuncture and administration per orally of Whangryonhaedogtang and Onsungouhyoulbang. K.O.M.S. 1994; 15(1):9-25.

39

秦秀兰, 吴锦梅, 郑有顺. 黄连解毒汤镇痛抗炎作 用的实验研究. Pharmacology and Clinics of Chinese Materia Medica. 1994; (6):9-10.

40

Wang LM, Yamamoto T, Wang XX, Yang L, Koike Y, Shiba K, et al. Effects of Oren-gedoku-to and Unsei-in, Chinese traditional medicines, on interleukin-8 and superoxide dismutase in rats. J Pharm Pharmacol. 1997; 49:102-104.      

41

戴毅, 野口光一. ラット末梢炎症モデルにおける 神経ペプチド遺伝子発現に対する黄連解毒湯の 影響. The general meeting of Medical and Pharmaceutical Society for Wakan-yaku abstracts. 1998;15:73.

42

Cinzia Papadia C, Alessandro Coruzzi A, Chiara Montana C, Di Mario F, Franze A, Forbes A. Omega-3 fatty acids in the maintenance of ulcerative colitis. J R Soc Med Sh Rep. 2010; 1(1):1-4.

43

Tanaka KI, Suemasu S, Ishihara T, Tasaka Y, Arai Y, Mizushima T. Inhibition of both COX-1 and COX-2 and resulting decrease in the level of prostaglandins E2 is responsible for non-steroidal anti-inflammatory drug (NSAID)- dependent exacerbation of colitis. Eur J Pharmacol. 2009; 603(1-3):120-132.

44

Sheibanie AF, Yen JH, Khayrullina T, Emig F, Zhang M, Tuma R, et al. The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the  axis. J Immunol. 2007; 178(12):8138-8147.

45

LeBlanc JG, del Carmen S, Miyoshi A, Azevedo V, Sesma F, Langella P, et al. Use of superoxidedismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in mice. J Biotechnol. 2011; 151(3):287-      

46

Joaquim Segui J, Gironella M, Sans M, Granell S, Gil F, Gimeno M, et al. Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine. J Leukoc Biol. 2004; 76(3):537-544.      

47

Lee IA, Hyun YJ, Kim DH. Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and  activation. Eur J Pharmacol. 2010; 648:162-170.   

48

Amaro MI, Rocha J, Vila-Real H, Eduardo-Figueira M, Mota-Filipe H, Sepodes B, et al. Anti-inflammatory activity of naringin and the biosynthesised naringenin by naringinase immobilized in microstructured materials in a model of DSS-induced colitis in mice. Food Research International. 2009; 42:1010-1017.      

49

Xu L, Yang ZL, Li P, Zhou YQ. Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium. Phytomedicine. 2009; 16:989-995.      

50

Cho EY, Choi SC, Lee SH, Ahn JY, Im LR, Kim JH, et al. Nafamostat mesilate attenuates colonic inflammation and mast cell infiltration in the experimental colitis. Int Immunopharmacol. 2011; 11:412-417.      

51

Pavlick KP, Ostanin DV, Furr KL, Laroux FS, Brown CM, Gray L, et al. Role of T-cell-associated lymphocyte function-associated antigen-1 in the pathogenesis of experimental colitis. Int Immunol 2006; 18(2):389-398.

52

Zhang RX, Lao L, Qiao JT, Ruda MA. Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation. Neurosci Lett. 2003; 353(3):213-216.      

53

Lightman SL. The neuroendocrinology of stress: a never ending story. J Neuroendocrinol. 2008; 20:880-884.

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